Trifluoroacetic acid → Ethyl 2-(6-(methylamino)pyridin-2-yl)acetate
Reaction equation
C(O[N:6]([C:10]1[N:15]=[C:14]([CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH:13]=[CH:12][CH:11]=1)[C:7](C)=O)(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[CH3:7][NH:6][C:10]1[N:15]=[C:14]([CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH:13]=[CH:12][CH:11]=1Participants
4
Procedure
To a solution of ethyl 2-{6-[(tert-butoxy)-N-methylcarbonylamino]-2-pyridyl}acetate (3.56 g, 12.1 mmol) in dichloromethane (15 ml) was added trifluoroacetic acid (8 ml). The reaction was stirred for 16 h. The solvent was removed under vacuum and the crude product was chromatographed over silica gel to yield 2.2 g (100%) of Ethyl 2-[6-(methylamino)-2-pyridyl]acetate.
Workup
- customThe solvent was removed under vacuum
- customthe crude product was chromatographed over silica gel
Sources & evidence
- ORD record
- ord-fe756ca3d2c144cfbc76617fb511544d
- Source dataset
- uspto-grants-2005_03
- Patent number
- US06872730B2
Reaction notes
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