4-[4-(4-Fluorophenyl)methylphenyl]piperidine → 5-[4-(4-(4-(4-Fluorophenyl)methylphenyl)piperidin-1-yl)butyryl]-2,3,4,5-tetrahydro-1,5-benzoxazepine

HRID 986

Reaction equation

HRID 986 reaction equation
Cl[CH2:2][CH2:3][CH2:4][C:5]([N:7]1[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=2[O:11][CH2:10][CH2:9][CH2:8]1)=[O:6].[F:18][C:19]1[CH:24]=[CH:23][C:22]([CH2:25][C:26]2[CH:31]=[CH:30][C:29]([CH:32]3[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]3)=[CH:28][CH:27]=2)=[CH:21][CH:20]=1>>[F:18][C:19]1[CH:20]=[CH:21][C:22]([CH2:25][C:26]2[CH:31]=[CH:30][C:29]([CH:32]3[CH2:33][CH2:34][N:35]([CH2:2][CH2:3][CH2:4][C:5]([N:7]4[C:13]5[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=5[O:11][CH2:10][CH2:9][CH2:8]4)=[O:6])[CH2:36][CH2:37]3)=[CH:28][CH:27]=2)=[CH:23][CH:24]=1

Participants

3

Reactant 2

HCID 154621204-[4-(4-Fluorophenyl)methylphenyl]piperidineHCID 196942505-(4-Chlorobutyryl)-2,3,4,5-tetrahydro-1,5-benzoxazepine

Product 1

HCID 196942735-[4-(4-(4-(4-Fluorophenyl)methylphenyl)piperidin-1-yl)butyryl]-2,3,4,5-tetrahydro-1,5-benzoxazepine

Procedure

The compound (16) synthesized in Reference Example 16 and the compound (7) synthesized in Reference Example 7 were used to produce the above compound in the same way as Example 1.

Workup

  1. customto produce the above compound in the same way as Example 1

Sources & evidence

ORD record
ord-1255beb210e449d39ea430d3d1fca98e
Source dataset
uspto-grants-1998_03
Patent number
US05723475

Linked notes

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