[CH:1]([NH:4][CH2:5][C:6]([CH3:9])([NH2:8])[CH3:7])([CH3:3])[CH3:2].[CH:10](Cl)(Cl)Cl.C(N(C[CH2:24][CH2:25][CH3:26])CCCC)CCC.[OH-:27].[Na+]>CC(C)=O>[CH:1]([N:4]1[CH2:10][C:25]([CH3:24])([CH3:26])[NH:8][C:6]([CH3:9])([CH3:7])[C:5]1=[O:27])([CH3:3])[CH3:2]In a 1 liter flask cooled in an ice-bath, put 1 g mol of N1 -isopropyl-2-methyl-1,2-propanediamine, 1.25 g mols of chloroform, and, 1.25 g mols of acetone. Add about 5% by wt tributylamine as the phase transfer catalyst, and slowly drip into the flask about 3 g mols of 50% aqueous NaOH solution, while stirring. Upon working up the reaction product in a conventional manner, a reaction product is obtained which is predominantly the compound represented by the structural formula immediately hereinabove. A minor amount of N1 -isopropyl-3,3,6,6-tetramethyl-piperazin-2-one is also recovered.
Loading…
