Silicon carbide → 1,2,4-Trimethoxy-5-nitrobenzene

HRID 986632

Reaction equation

HRID 986632 reaction equation
[CH3:1][O:2][C:3]1[C:8]([O:9][CH3:10])=[CH:7][C:6](Cl)=[C:5]([N+:12]([O-:14])=[O:13])[CH:4]=1.[C-]#[Si+].[C:17]([O-])([O-])=[O:18].[K+].[K+]>>[CH3:17][O:18][C:6]1[CH:7]=[C:8]([O:9][CH3:10])[C:3]([O:2][CH3:1])=[CH:4][C:5]=1[N+:12]([O-:14])=[O:13]

Participants

4

Reactant 3

HCID 9863Silicon carbideHCID 11430Potassium CarbonateHCID 123212731-Chloro-4,5-dimethoxy-2-nitrobenzene

Product 1

HCID 8224151,2,4-Trimethoxy-5-nitrobenzene

Procedure

Into a two liter flask, provided with a cooling device, were introduced successively a solution of methanolic potash (100 g of KOH and 500 cm3 of methanol), then 100 g (0.46 mole) of 4,5-dimethoxy 2-nitro chlorobenzene and carborundum. The mixture was brought to boiling under reflux for 6 h. After cooling, the reaction medium was filtered; the precipitate obtained was washed with methanol.

Workup

  1. customInto a two liter flask, provided with a cooling device
  2. temperatureunder reflux for 6 h
  3. temperatureAfter cooling
  4. filtrationthe reaction medium was filtered
  5. customthe precipitate obtained
  6. washwas washed with methanol

Sources & evidence

ORD record
ord-baa8f31480994247bd915526e8860d87
Source dataset
uspto-grants-1987_12
Patent number
US04714700

Linked notes

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