Hydrogen Bromide → HCID 18007940, compound
Reaction equation
Br.C[O:3][C:4]1[CH:13]=[C:12]2[C:7]([CH:8]=[CH:9][CH:10]=[C:11]2[CH2:14][C:15]([OH:17])=[O:16])=[CH:6][CH:5]=1>C(O)(=O)C>[OH:3][C:4]1[CH:13]=[C:12]2[C:7]([CH:8]=[CH:9][CH:10]=[C:11]2[CH2:14][C:15]([OH:17])=[O:16])=[CH:6][CH:5]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
In a 250 ml round-bottomed flask, dissolve 2-(7-methoxynaphth-1-yl)acetic acid in acetic acid. Add hydrobromic acid and reflux the reaction mixture for 4 hours. Remove the acetic acid and hydrobromic acid by evaporation under reduced pressure. Take up the solid in water and suction it off. Wash the precipitate with petroleum ether and recrystallise it from toluene.
Workup
- customRemove the acetic acid and hydrobromic acid
- customby evaporation under reduced pressure
- washWash the precipitate with petroleum ether
- customrecrystallise it from toluene
Sources & evidence
- ORD record
- ord-6d78c4390c6245dca914947d9e6d8e6f
- Source dataset
- uspto-grants-2003_10
- Patent number
- US06635650B2
Reaction notes
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