Ammonia methanol → 7-Sulfamoylimidazo[5,1-b]thiazole
Reaction equation
[NH3:1].CO.Cl[S:5]([C:8]1[N:9]=[CH:10][N:11]2[CH:15]=[CH:14][S:13][C:12]=12)(=[O:7])=[O:6]>C1COCC1>[S:5]([C:8]1[N:9]=[CH:10][N:11]2[CH:15]=[CH:14][S:13][C:12]=12)(=[O:7])(=[O:6])[NH2:1]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A 2 M ammonia/methanol solution (4 ml) was added to a solution of 0.44 g of 7-chlorosulfonylimidazo[5,1-b]thiazole in 10 ml of THF. The mixture was stirred at room temperature for 12 hr. The reaction mixture was concentrated. The residue was purified by column chromatography on silica gel (dichloromethane:methanol=10:1) to give 0.34 g of 7-sulfamoylimidazo[5,1-b]thiazole.
Workup
- concentrationThe reaction mixture was concentrated
- customThe residue was purified by column chromatography on silica gel (dichloromethane:methanol=10:1)
Sources & evidence
- ORD record
- ord-68e035aa4b924d19b3ebc853d3385982
- Source dataset
- uspto-grants-2002_10
- Patent number
- US06458780B1
Reaction notes
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