Diethylene Glycol Monoethyl Ether → Amitriptyline ketamine

HRID 990584

Reaction equation

[CH3:1][NH:2][C:3]1([C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:15]=2[Cl:16])[C:8](=[O:9])[CH2:7][CH2:6][CH2:5][CH2:4]1.Cl.[CH3:18][N:19]([CH2:21][CH2:22][CH:23]=[C:24]1[C:34]2[CH:35]=[CH:36][CH:37]=[CH:38][C:33]=2[CH2:32][CH2:31][C:30]2[CH:29]=[CH:28][CH:27]=[CH:26][C:25]1=2)[CH3:20].Cl.CCOCCOCCO>>[CH3:18][N:19]([CH2:21][CH2:22][CH:23]=[C:24]1[C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][C:30]=2[CH2:31][CH2:32][C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][C:34]1=2)[CH3:20].[CH3:1][NH:2][C:3]1([C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:15]=2[Cl:16])[C:8](=[O:9])[CH2:7][CH2:6][CH2:5][CH2:4]1

Participants

Reactant 3

HCID 8146Diethylene Glycol Monoethyl Ether

HCID 11065Amitriptyline Hydrochloride2×

HCID 15851Ketamine Hydrochloride2×

Product 1

HCID 9892707Amitriptyline ketamine

Procedure

0.3750 gm ketamine hydrochloride USP and 0.750 gm amitriptyline hydrochloride USP are combined and wetted with 2.0 ml of ethoxy diglycol reagent, and stirred into 75 gm of the base cream prepared as per example 3 and triple milled. The cream-type mixture contains ketamine hydrochloride at 5 mg/ml and amitriptyline hydrochloride at 10 mg/ml.

Sources & evidence

ORD record: ord-e770c9deff2d4242b4c06fba70b039da
Source dataset: uspto-grants-2002_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06461600B1

Linked notes

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