Dimethylamine, hydrochloride (HCID 10473)

名称と識別子

優先名称: Dimethylamine, hydrochloride
IUPAC: N-methylmethanamine;hydrochloride
現地名: ジメチルアミン塩酸塩
英語名: Dimethylamine hydrochloride
分子式: C2H8ClN
分子量: 81.54

名称と別名

Dimethylamine hydrochloride506-59-2Dimethylammonium chlorideDimethylamine, hydrochlorideHydrochloric acid dimethylamine7M4CWB6AOKRefChem:588486208-046-5N-Methylmethanamine hydrochlorideMethanamine, N-methyl-, hydrochlorideDIMETHYLAMINE HClMFCD00012477

名称をさらに表示

ジメチルアミン塩酸塩ジメチルアミン·塩酸塩ジメチルアミン·塩酸ジメチルアミン塩酸塩（1：1）ジメチルアンモニウムクロリドジメチルアミン塩酸塩塩化ジメチルアンモニウムMETHANAMINE HYDROCHLORIDEDMAClMetformin impurity F CRSDiMethylaMine hydrochloridMetformin EP Impurity F HClJACS-506-59-2Dimethylamine hydrocImatinib EP Impurity I

C2H8ClNN,N-dimethylamine hydrochlorideDTXSID8027163N-methylmethanamine;hydrochlorideMethanamine, N-methyl-, hydrochloride (1:1)DIMETHYLAMINE-15-N HYDROCHLORIDEDimethyl amine hydrochloridedimethyl ammonium chloride

データベース識別子

CAS: 506-59-2
PubChem CID: 10473
DTXSID: DTXSID8027163
ChEMBL: CHEMBL569461
UNII: 7M4CWB6AOK
EC Number: 208-046-5

物性

構造計算による物性

極性表面積: 12 Å²
水素結合供与体数: 2
水素結合受容体数: 1
回転可能結合数: 0
重原子数: 4
形式電荷: 0
複雑度: 2.8

実験および物理化学的性質

Chemical ClassesNitrogen Compounds -> Amines, Aliphatic

Vapor Pressure0.000435 [mmHg]

Physical DescriptionDeliquescent solid; [Merck Index] White to off-white odorless solid; Hygroscopic; [Acros Organics MSDS]

物理化学的性質

融点: 170 · 170-173 °C(lit.)
沸点: 95.79 °C · 95.79°C (rough estimate)
比重(密度): 0.8949 · 0.8949 (rough estimate)
蒸気圧: 0.1 hPa · <0.1 hPa (25 °C)
屈折率: 1.4202 · 1.4202 (estimate)
貯蔵温度: 30 °C · Store below +30°C.
溶解性: 2 O: · H2O: 可溶0.5g/10mL
外見: 結晶性粉末または結晶
色: ホワイトからオフホワイト
PH: 5 · 5 (100g/l, H2O, 20℃)
水溶解度: 3000 g/L · 3000g/L（20℃）
Merck: 14 · 14,3228
BRN: 3589311 · 3589311
安定性: 安定。強力な酸化剤とは相容れない。
InChI: 1S/C2H7N.ClH/c1-3-2;/h3H,1-2H3;1H
InChIKey: IQDGSYLLQPDQDV-UHFFFAOYSA-N
SMILES: Cl[H].CNC
LogP: -3.28 · -3.28
CAS データベース: 506 · 506-59-2(CAS DataBase Reference)
EPAの化学物質情報: Methanamine, N-methyl-, hydrochloride (506-59-2)

化学的性質

化学的特性White, foliage-like crystals with a melting point of 171°C. Highly soluble in water, soluble in alcohol and chloroform, and insoluble in ether. Exhibits deliquescence.

安全と法規制

GHS分類

GHS Classification · 6 件

Warning

H302 (99.7%): Harmful if swallowed [Warning Acute toxicity, oral]

P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 363 reports by companies from 12 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Warning

H302: Harmful if swallowed [Warning Acute toxicity, oral]

危険有害性情報

Regulatory Information · 3 件

Chemical: Methanamine, N-methyl-, hydrochloride

Status: Active Update: 17-09-2021 https://echa.europa.eu/registration-dossier/-/registered-dossier/13403

Dimethylammonium chloride: Does not have an individual approval but may be used under an appropriate group standard

Hazards SummaryAn irritant; Possible reproductive and fetal toxicant, based on animal studies; [Acros Organics MSDS] See Dimethylamine.

Hazard Classes and Categories · 2 件

Acute Tox. 4 (99.7%)

Acute toxicity (Oral) - Category 4

安全データ

F: 3-9
wgk: 1
tsca: TSCA listed
rtecs: IQ0220000
毒性: LD50 in mice (g/kg): 1.21 i.v., 2.00 s.c. (Hazard); LC50 in mice (ppm): 7650 (48 hr), 4725 (14 day); in rats (ppm): 4540 (6 hr) (Steinhagen)
hs_code: 29211190
risk_code: 22-36/37/38
化審法: (2)-134
hazard_code: Xn
safety_code: 26-36/37-37/39-36
Hazard Classifications: Acute Tox. 4 OralEye Irrit. 2Skin Irrit. 2
ストレージクラス: 11 - Combustible Solids

化学と産業

用途と製造

Uses · 2 件

Used as a rubber accelerator and in leather tanning; Also used to make detergents and as a boll weevil attractant; [Merck Index] Used as a catalyst for polymerization reactions, epoxy monomer for paints-coatings-thinners and polymers, to make fine and large scale chemicals, pharmaceuticals, and pesticides, and in electricity-steam-gas-water supply and sewage treatment; [ExPub: ECHA REACH Registrations]

Painting (Pigments, Binders, and Biocides) [Category: Paint]

General Manufacturing InformationMethanamine, N-methyl-, hydrochloride (1:1): ACTIVE

応用分野 · 4 件

用途医薬原料、フラックス、有機合成原料等。

用途有機合成原料、加硫促進剤。

説明Dimethylamine hydrochloride is the raw material of organic synthesis, the catalyzer of analysis as an acetylize, and the preparation of azoviolet and dimethylamine aqueous solution. Dimethylamine hydrochloride deoxidation is very capable, and corrodibility is vital, so be usually used in cleaning-type soldering flux. Preparation technology is for slowly splashing into hydrochloric acid in dimethylamine for tradition, and the speed that splashes into is no more than 15 ℃ with temperature, and pH=7-8 is limited. After the reaction finishes, activated carbon decolorizing is added, the filtrate is adjusted to pH=3-4 with hydrochloric acid, decompression is steamed water to the greatest extent, obtaining dimethylamine hydrochloride.

使用Dimethylamine hydrochloride is a precursor to several industrially significant compounds.

調製方法

製造方法Dimethylamine hydrochloride is obtained from the salt formation of dimethylamine and hydrochloric acid.

純化方法Crystallise the salt from hot CHCl3 or absolute EtOH. It also recrystallises from MeOH/ether solution. Dry it in a vacuum desiccator over H2SO4, then P2O5. Hygroscopic. [Beilstein 4 IV 132.]

上流・下流製品情報

上流原料

ジメチルアミン

下流製品

4-(ジメチルアミノ)ピペリジン 2-Methyl-4-trifluoromethyl-nicotinic acid N,N-ジメチル-2-クロロアセトアミド 5-Butylpyridine-2-carbonitrile Dimethylaminoacetyl chloride hydrochloride (3S)-(-)-3-(ジメチルアミノ)ピロリジンフザリン酸ジメチルスルファモイルクロリドオンダンセトロン 3-アミノ-N,N-ジメチルベンゼンスルホンアミド (3R)-(+)-3-(ジメチルアミノ)ピロリジンエタクリン酸

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爱斯特（成都）生物制药股份有限公司+86-28-85122536 85324413 · [email protected]

ジメチルアミン塩酸塩

基本情報