Tetrahydrofuran → 5-benzyloxy-2-(N,N-dimethylamino)methyl-4-pyridone

HRID 5512

反応式

HRID 5512 の反応式
Cl[CH2:2][C:3]1[CH2:8][C:7](=[O:9])[C:6]([O:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:5][N:4]=1.O1CCCC1.Cl.[CH3:24][NH:25][CH3:26].[OH-].[Na+]>O>[CH2:11]([O:10][C:6]1[C:7](=[O:9])[CH2:8][C:3]([CH2:2][N:25]([CH3:26])[CH3:24])=[N:4][CH:5]=1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

参加物

6

反応物 4

HCID 8028TetrahydrofuranHCID 10473Dimethylamine, hydrochlorideHCID 14798Sodium HydroxideHCID 677480612-Chloromethyl-5-benzyloxy-4-pyridone

生成物 1

HCID 677480495-benzyloxy-2-(N,N-dimethylamino)methyl-4-pyridone収率 96.7%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a mixture of 2-chloromethyl-5-benzyloxy-4-pyridone (1.0 g), tetrahydrofuran (10 ml) and water (10 ml) were added dimethylamine hydrochloride (1.31 g) and sodium hydroxide (0.64 g). After being stirred for 1.5 hours, the mixture was concentrated under reduced pressure to dryness. The residue was dissolved in methanol and the insoluble material was filtered off. The filtrate was evaporated in vacuo to give 5-benzyloxy-2-(N,N-dimethylamino)methyl-4-pyridone (1.0 g) as a powder.

後処理

  1. concentrationthe mixture was concentrated under reduced pressure to dryness
  2. dissolutionThe residue was dissolved in methanol
  3. filtrationthe insoluble material was filtered off
  4. customThe filtrate was evaporated in vacuo

出典と根拠

ORDレコード
ord-5543a960e72d4b11830530e7308453a5
出典データセット
uspto-grants-1993_09
特許番号
US05244890

関連ノート

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