p-トルイジン塩酸塩

Benzenamine, 4-methyl-, hydrochloride (1:1)

HCID 10891

基本情報

CAS
540-23-8
標準SMILES
Cc1ccc(N)cc1.Cl
InChIKey
JQKBUTDZZRGQDR-UHFFFAOYSA-N
分子式
C7H10ClN
平均分子量
143.61 g/mol
単同位体質量
143.050177

名称と識別子

優先名称
Benzenamine, 4-methyl-, hydrochloride (1:1)
IUPAC
4-methylaniline;hydrochloride
現地名
p-トルイジン塩酸塩
英語名
4-Methylaniline hydrochloride
分子式
C7H10ClN
分子量
143.61

名称と別名

p-Toluidine hydrochloride540-23-84-Aminotoluene hydrochloride4-Methylanilinium chloridep-Methylanilinium chloride4-Methylbenzenamine hydrochloridep-Toluidine, hydrochloridePT5II901IFBenzenamine, 4-methyl-, hydrochloride (1:1)P-METHYLANILINE HYDROCHLORIDE4-METHYLPHENYLAMMONIUM CHLORIDE4-toluidine hydrochloride
名称をさらに表示
p-トルイジン塩酸塩4-メチルアニリン·塩酸塩4-メチルアニリン·塩酸p-トルイジン·塩酸塩p-トルイジン塩酸塩酸p-トルイジンpトルイジン酸4-トルイジン塩酸塩4-メチルアニリン塩酸塩P-トルイジン 塩酸塩4-メチルアニリン・塩酸4-メチルアニリン・塩酸塩p-トルイジン・塩酸塩4-methylaniline HCLToluidinium chloridep-Toluidine hydrochloriρ-Toluidine hydrochliride4-methylaniliniumchloridep-methylaniliniumchloride
RefChem:169393208-740-84-Methylaniline hydrochloridep-Toluidine.HClBenzenamine, 4-methyl-, hydrochloridep-TOLUIDINE HClP-TOLUIDINIUM CHLORIDEDTXSID2021365

データベース識別子

CAS
540-23-8
PubChem CID
10891
DTXSID
DTXSID2021365
ChEMBL
CHEMBL3183830
UNII
PT5II901IF
EC Number
208-740-8

物性

構造計算による物性

極性表面積
26 Ų
水素結合供与体数
2
水素結合受容体数
1
回転可能結合数
0
重原子数
9

実験および物理化学的性質

Solubilitygreater than or equal to 100 mg/mL at 68 °F (NTP, 1992)
Boiling Point495.5 °F at 760 mmHg (NTP, 1992)
Melting Point469 °F (NTP, 1992)
Physical Description · 2 件

P-toluidine hydrochloride appears as off-white to grayish-white crystals. (NTP, 1992)

Off-white to grayish-white solid; [CAMEO] Off-white powder; [Anachemia MSDS]

物理化学的性質

融点
243 · 243-245 °C(lit.)
比重(密度)
1.193 g/cm3 · 1.193 g/cm3
貯蔵温度
30 °C · Store below +30°C.
水溶解度
Soluble in water
溶解性
DMSO (Sparingly), Methanol (Slightly)
外見
powder to crystal

化学的性質

化学的特性white to light beige crystalline powder, crystals

安全と法規制

GHS分類

GHS Classification · 6 件

Danger

H301: Toxic if swallowed [Danger Acute toxicity, oral];H311: Toxic in contact with skin [Danger Acute toxicity, dermal];H317: May cause an allergic skin reaction [Warning Sensitization, Skin];H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation];H331: Toxic if inhaled [Danger Acute toxicity, inhalation];H351: Suspected of causing cancer [Warning Carcinogenicity];H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

P203, P261, P262, P264, P264+P265, P270, P271, P272, P273, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P316, P318, P321, P330, P333+P317, P337+P317, P361+P364, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

Danger

危険有害性情報

Regulatory Information · 2 件

Chemical: Benzenamine, 4-methyl-, hydrochloride

4-Toluidine hydrochloride: Does not have an individual approval but may be used under an appropriate group standard

Other Safety InformationIMAP assessments - p-Toluidine and its salts: Human health tier II assessment
Fire HazardsFlash point data for this chemical are not available, but it is probably combustible. (NTP, 1992)
Health Hazards · 1 件

SYMPTOMS: Symptoms of exposure to this compound are cyanosis, air hunger, nausea, vomiting, low blood pressure and convulsions. Chronic exposure results in weight loss, weakness and anemia.;ACUTE/CHRONIC HAZARDS: When heated to decomposition this compound emits very toxic fumes. (NTP, 1992)

Hazards Summary · 1 件

A skin and severe eye irritant; May cause skin sensitization; May induce methemoglobinemia; Highly toxic by ingestion, inhalation, and skin absorption; Targets the blood, liver, kidney, and lung; Possible mutagen and carcinogen; [Anachemia MSDS] See p-Toluidine.

Reactive GroupSalts, Acidic

安全と保護具

Fire FightingFires involving this compound should be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
First Aid · 1 件

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.;SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.;INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.;INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

Nonfire Spill Response · 1 件

SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.;STORAGE PRECAUTIONS: You should store this chemical under refrigerated temperatures, protect from moisture and keep it away from oxidizing materials. (NTP, 1992)

Personal Protective Equipment (PPE) · 1 件

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

毒性情報

Adverse EffectsMethemoglobinemia - The presence of increased methemoglobin in the blood; the compound is classified as secondary toxic effect;Skin Sensitizer - An agent that can induce an allergic reaction in the skin.

法規制情報

Regulatory Information · 2 件

Chemical: Benzenamine, 4-methyl-, hydrochloride

4-Toluidine hydrochloride: Does not have an individual approval but may be used under an appropriate group standard

安全データ

wgk
3
tsca
TSCA listed
rtecs
XU7525000
ridadr
UN 2811 6.1/PG 1
hs_code
29214300
risk_code
23/24/25-36-40-43-50

化学と産業

用途と製造

UsesUsed as an intermediate for dyes and for glucose detection in blood; [NTP]
General Manufacturing InformationBenzenamine, 4-methyl-, hydrochloride (1:1): INACTIVE

応用分野

一般的な説明Off-white to grayish-white crystals.

調製方法

純化方法Crystallise the salt from MeOH containing a few drops of conc HCl or aqueous EtOH. Dry it under vacuum over paraffin chips. [Beilstein 12 II 587, 12 III 2021, 12 IV 1869.]

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関連反応

6 件

化合物ノート

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