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Fire Extinguishing Agents Not to Be Used: Water may be ineffective.

Use alcohol-resistant foam, powder, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.

Fresh air, rest.

Remove contaminated clothes. Rinse skin with plenty of water or shower.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Give one or two glasses of water to drink.

Excerpt from NIOSH Pocket Guide for sec-Amyl acetate:

(General first aid procedures)

If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use "alcohol" foam, carbon dioxide, or dry chemical. /Amyl acetate/

Respiratory protection for fire fighting: Self-contained breathing apparatus with a full facepiece operated in pressure-demand or other positive pressure mode.

1) Remove all sources of ignition. 2) Ventilate area of spill or leak. 3) For small quantities, absorb on paper towels. Evaporate in safe place (such as fume hood). Allow sufficient time for evaporating vapors to ... clear hood ductwork. Burn paper in suitable location away from combustible materials. Large quantities can be collected & atomized in suitable combustion chamber. sec-Amyl acetate should not be allowed to enter confined space, such as sewer ... .

Environmental consideration - Land spill: Dig a pit, pond, lagoon, or holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete. Apply fluorocarbon-water foam to diminish vapor and fire hazard. /Amyl acetate/

Environmental considerations - Water spill: Use natural barriers or oil spill control booms to limit spill motion. Use surface active agent (eg; detergent, soaps, alcohols) to compress and thicken spilled material. Inject "universal" gelling agent to solidify encircled spill and increase effectiveness of booms. If dissolved, apply activated carbon at ten times the spilled amount in region of 10 ppm or greater concn. Remove trapped material with suction hoses. Use mechanical dredges or lifts to remove immobilized masses of pollutants and precipitates. /Amyl acetate/

Environmental considerations - Air spill: Apply water spray or mist to knock down vapors. /Amyl acetate/

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Amyl acetate is a waste chemical stream constituent which may be subjected to ultimate disposal by controlled incineration. /Amyl acetate/

... A complete respiratory protection program should be instituted which incl regular training, maintenance, inspection, cleaning, & evaluation. ... Clothing wet with liq sec-amyl acetate should be placed in closed containers for storage until it can be discarded or until provision is made for removal of sec-amyl acetate ... . If clothing is to be laundered ... the person performing operation should be informed of ... hazardous properties. Any clothing which becomes wet with liq sec-amyl acetate should be removed ... & not reworn until sec-amyl acetate is removed ...

If material not on fire and not involved in fire: Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Attempt to stop leak if without hazard. Use water spray to disperse vapors and dilute standing pools of liquid. Avoid breathing vapors. Keep upwind. Do not handle broken packages without protective equipment. /Amyl acetate/

The worker should immediately wash the skin when it becomes contaminated.

Work clothing that becomes wet should be immediately removed due to its flammability hazard.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 400(SRC), determined from an estimated log Kow of 2.26(2,SRC) and a regression-derived equation(3), indicates that sec-amyl acetate is expected to have moderate mobility in soil(SRC). Volatilization of sec-amyl acetate from moist soil surfaces may be an important fate process(SRC) given an estimated Henry's Law constant of 7.9X10-4 atm-cu m/mole(SRC), using a fragment constant estimation method(4). The potential for volatilization of sec-amyl acetate from dry soil surfaces may exist(SRC) based on an estimated vapor pressure of 9.8 mm Hg(SRC), determined from a fragment constant method(5). Biodegradation of sec-amyl acetate may be important in soil(SRC), based upon biodegradation of 4-methyl-2-pentyl acetate, a structural analog of sec-amyl acetate, in aerobic screening tests(6).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 400(SRC), determined from an estimated log Kow of 2.26(2,SRC) and a regression-derived equation(3), indicates that some adsorption of sec-amyl acetate to suspended solids and sediment in water is expected(SRC). sec-Amyl acetate is expected to volatilize from water surfaces(3,SRC) based on an estimated Henry's Law constant of 7.9X10-4 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). Estimated volatilization half-lives for a model river and model lake are 4.7 hours and 4.9 days, respectively(3,SRC). Volatilization may be attenuated by adsorption to suspended solids and sediment in the water column(SRC). According to a classification scheme(5), an estimated BCF of 11(3,SRC), from an estimated log Kow(2,SRC), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Estimated hydrolysis half-lives of 3.6 years and 130 days at pH values of 7 and 8, respectively(6), suggest that hydrolysis is not expected to be an important process(SRC). sec-Amyl acetate is expected to biodegrade in aquatic systems based upon its structural similarity to 4-methyl-2-pentyl acetate(SRC). In aerobic screening tests using an unacclimated sewage seed, 4-methyl-2-pentyl acetate reached 20, 87, 62 and 69% of its theoretical BOD in freshwater and 11, 22, 52, and 67% of its theoretical BOD in synthetic seawater after 5, 10, 15, and 20 days, respectively(7).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), sec-amyl acetate, which has an estimated vapor pressure of 9.8 mm Hg at 25 °C(2,SRC), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase sec-amyl acetate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 2.4 days(3,SRC).

The substance can be absorbed into the body by inhalation of its vapour.

inhalation, ingestion, skin and/or eye contact

Cough. Dizziness. Drowsiness. Headache. Sore throat.

Dry skin. Redness.

Redness. Pain.

irritation eyes, skin, nose; narcosis; dermatitis; possible kidney, liver injury; possible central nervous system depression

Kidney disease: ... the importance of this organ in elimination of toxic substances justifies special consideration in those with impaired renal function. Chronic resp disease: in those persons with impaired pulmonary function, esp those with obstructive airway diseases, the breathing of sec-amyl acetate might cause exacerbation of symptoms due to its irritant properties. Liver disease: ... the importance of this organ in biotransformation & detoxification of foreign substances should be considered before exposing persons with impaired liver function. Skin disease: sec-amyl acetate is a defatting agent & can cause dermatitis on prolonged exposure. Persons with pre-existing skin disorders may be more susceptible to effects of this agent. Periodic Medical Exam: Any employee developing ... listed conditions should be referred for further medical exam.

The Koc of sec-amyl acetate is estimated as approximately 400(SRC), using an estimated log Kow of 2.26(1,SRC) and a regression-derived equation(2,SRC). According to a classification scheme(3), this estimated Koc value suggests that sec-amyl acetate is expected to have moderate mobility in soil(SRC).

Irritation of eyes & upper resp tract is first response to vapor ... & may occur at concn above 300 ppm. At very high concn there may be depression of CNS ... .

Chronic worker exposure caused upper resp & /CNS depressant/ effects.

sec-Amyl acetate can affect the body if it is inhaled, comes in contact with eyes or skin, or is swallowed.

Secondary amyl acetate is thought to be qualitatively (and perhaps quantitatively) similar in toxicity to /isoamyl acetate/.

For more Human Toxicity Excerpts (Complete) data for 2-PENTYL ACETATE (6 total), please visit the HSDB record page.

sec-Amyl acetate's production and use as a solvent for nitrocellulose and ethyl cellulose, cements, coated paper, lacquers, leather finishes, nail enamels, plastic wood, textile sizing, and printing compounds(1) may result in its release to the environment through various waste streams(SRC).

Biodegradation data on sec-amyl acetate were not available(SRC). However in aerobic screening tests using an unacclimated sewage seed, 4-methyl-2-pentyl acetate reached 20, 87, 62 and 69% of its theoretical BOD after 5, 10, 15, and 20 days, respectively in freshwater(1). In aerobic screening tests using synthetic seawater with added raw wastewater, 4-methyl-2-pentyl acetate reached 11, 22, 52, and 67% of its theoretical BOD after 5, 10, 15, and 20 days, respectively(1). Based upon the structural similarity of sec-amyl acetate to 4-methyl-2-pentyl acetate, biodegradation of sec-amyl acetate is expected to be an important fate process(SRC).

An estimated BCF of 11 was calculated for sec-amyl acetate(SRC), using an estimated log Kow of 2.26(1,SRC) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 5000 lb or 2270 kg. The toll free number of the NRC is (800) 424-8802; In the Washington D.C. metropolitan area (202) 426-2675. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).