2-Pentanol → 2-Pentyl acetate

2-Pentanol (176 g, 2.0 mol, Aldrich) and sodium acetate (18 g, 10 Aldrich) were heated to 90° C. and then acetic anhydride (240 ml, BDH GPR) was added over a 1 hour period at 100-110° C. The mixture was heated to reflux for 4 hours. The reaction mixture was then cooled, washed with water, washed with aqueous sodium bicarbonate to neutrality, dried over sodium sulfate, and then concentrated. Fractional distillation of the crude residue under vacuum provided 1-methylbutyl acetate (80-81°/140-145 mm Hg, 77% yield), the structure of which was confirmed by mass spectroscopy, nuclear magnetic resonance spectroscopy, and infra red spectroscopy (not shown).

1. temperatureThe mixture was heated
2. temperatureto reflux for 4 hours
3. temperatureThe reaction mixture was then cooled
4. washwashed with water
5. washwashed with aqueous sodium bicarbonate to neutrality
6. dry with materialdried over sodium sulfate
7. concentrationconcentrated
8. distillationFractional distillation of the crude residue under vacuum

ORDレコード

ord-5515ff45a39546c0ad52cc054be77f06

出典データセット

uspto-grants-1999_11

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US05993879