アクリロイルクロリド

Signs and Symptoms of Acrylyl Chloride Exposure: Acrylyl chloride may be very irritating to the skin, eyes, mucous membranes, and respiratory tract. Lacrimation (tearing) is common. Coughing and difficulty in breathing may be noted along with pulmonary edema in more severe exposures. Other signs and symptoms of acute exposure may include headache, dizziness, and weakness. Gastrointestinal effects may include nausea, vomiting, and diarrhea.

Suitable extinguishing media: Dry powder, dry sand

Advice for firefighters: Wear self-contained breathing apparatus for firefighting if necessary.

Use water spray to cool unopened containers.

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Recommended storage temperature 2-8 °C. Light sensitive. Reacts violently with water.

ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Wear respiratory protection. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Methods and materials for containment and cleaning up: Contain spillage, and then collect with non-combustible absorbent material, (e.g. sand, earth, diatomaceous earth, vermiculite) and place in container for disposal according to local/national regulations.

For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure-demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit.

SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.

Product: Contact a licensed professional waste disposal service to dispose of this material. Offer surplus and non-recyclable solutions to a licensed disposal company. Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Contaminated packaging: Dispose of as unused product.

ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Wear respiratory protection. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

Precautions for safe handling: Avoid contact with skin and eyes. Avoid inhalation of vapor or mist. Use explosion-proof equipment. Keep away from sources of ignition - No smoking. Take measures to prevent the build up of electrostatic charge.

Appropriate engineering controls: Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product.

Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.

SRP: The scientific literature for the use of contact lenses by industrial workers is inconsistent. The benefits or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

0.082 [mg/m3]

0.9 [mg/m3]

3.2 [mg/m3]

For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. (EPA, 1998)

Eye/face protection: Tightly fitting safety goggles. Faceshield (8-inch minimum). Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166 (EU).

Skin protection: Handle with gloves.

Body Protection: Complete suit protecting against chemicals. Flame retardant antistatic protective clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection: Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multipurpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

TERRESTRIAL FATE: As a class, acyl halides react readily with water to yield the parent acid and hydrogen halide(1-2). As a result, adsorption, volatilization and biodegradation are not expected to be important fate processes in moist soil(SRC). Acrylyl chloride is expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 115 mm Hg at 25 °C(SRC), determined from a fragment constant method(3).

AQUATIC FATE: As a class, acyl halides react readily with water to yield the parent acid and hydrogen halide(1-2). As a result, adsorption to suspended solids and sediment, bioconcentration, volatilization, and biodegradation are not expected to be important fate processes in aquatic systems(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), acrylyl chloride, which has an estimated vapor pressure of 115 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase acrylyl chloride is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals and ozone(SRC); the half-lives for these reactions in air are estimated to be 1.7 and 6.6 days(SRC), calculated from respective rate constants of 9.2X10-12 and 1.7X10-16 cu cm/molecule-sec at 25 °C(SRC), that were derived using a structure estimation method(2). Acrylyl chloride contains chromophores that absorb at wavelengths >290 nm(3) and, therefore, may be susceptible to direct photolysis by sunlight(SRC).

IDENTIFICATION AND USE: Acrylyl chloride is a liquid. It is used as a monomer and chemical intermediate. HUMAN STUDIES: Three university students were exposed to toxic vapors (acryloyl chloride 96% and methacrylic anhydride 94%) in a laboratory accident. They all gave a history of minimal exposure and presented with mild symptoms. One patient died on the same day. The other two cases were uneventful. ANIMAL STUDIES: Inhalation exposure to 100 ppm acrylyl chloride for 2 hr produced in rats lethargy and respiratory difficulty, during autopsy lung edema was noted.

As a class, acyl halides react readily with water to yield the parent acid and hydrogen halide(1-2). Analogous acetyl chloride and chloroacetyl chloride hydrolyze rapidly to yield acetic acid and hydrochloric acid(1), and chloroacetic acid and hydrochloric acid(2), respectively. Therefore, adsorption to soil and mobility are not expected to be important environmental fate processes(SRC).

/CASE REPORTS/ Three university students were exposed to toxic vapors (acryloyl chloride 96% and methacrylic anhydride 94%) in a laboratory accident. They all gave a history of minimal exposure and presented with mild symptoms. One patient died on the same day. The other two cases were uneventful. This paper reports on these three cases, followed by a discussion on irritant gas intoxication. /Mixture/

As a class, acyl halides react readily with water to yield the parent acid and hydrogen halide(1-2). Analogous acetyl chloride and chloroacetyl chloride hydrolyze rapidly to yield acetic acid and hydrochloric acid(1), and chloroacetic acid and hydrochloric acid(2), respectively. Therefore, biodegradation of acrylyl chloride is not expected to be an important environmental fate process(SRC).

As a class, acyl halides react readily with water to yield the parent acid and hydrogen halide(1-2). Analogous acetyl chloride and chloroacetyl chloride hydrolyze rapidly to yield acetic acid and hydrochloric acid(1), and chloroacetic acid and hydrochloric acid(2), respectively. Therefore, bioconcentration is not expected to be an important environmental fate process(SRC).

As a class, acyl halides react readily with water to yield the parent acid and hydrogen halide(1-2). Analogous acetyl chloride and chloroacetyl chloride hydrolyze rapidly to yield acetic acid and hydrochloric acid(1), and chloroacetic acid and hydrochloric acid(2), respectively. Therefore, volatilization of acrylyl chloride from water or moist soil surfaces is not expected to be an important environmental fate process(SRC). Acrylyl chloride is expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 115 mm Hg(SRC), determined from a fragment constant method(3).

/LABORATORY ANIMALS: Acute Exposure/ Acrylyl chloride /inhalation toxicity/ 100 ppm (D): 4M rats: 1 x 2-hr exposure: lethargy, respiratory difficulty, autopsy, lung edema 25 ppm (xylene): 4F rats: 1 x 4-hr exposure: eye irritation, respiratory difficulty, incoordination, 1 died: autopsy, lungs distended and edematous, (histol.) lung emphysema and edema 5 ppm (acetone): 4F rats: 5 x 5-hr exposures: eye irritation, respiratory difficulty, lethargy, low rectal temperature, weight loss, 3 rats died on 3rd day: autopsy (histol.) pneumonia 2-5 ppm (acetone): 4M 4F rats: 3 x 6-hr exposures: weight loss, low rectal temperature, 1 died: autopsy, lungs distended, (histol.) lung edema and inflammation 1 ppm (acetone): 4M4Frats: 15 x 6-hr exposures: no toxic signs: autopsy, organs normal.

The rate constant for the vapor-phase reaction of acrylyl chloride with photochemically-produced hydroxyl radicals has been estimated as 9.2X10-12 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 1.7 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). The rate constant for the vapor-phase reaction of acrylyl chloride with ozone has been estimated as 1.7X10-16 cu cm/molecule-sec at 25 °C(SRC), that was derived using a structure estimation method(1). This corresponds to an atmospheric half-life of about 6.6 days at an atmospheric concentration of 7X10+11 ozone molecules per cu cm(2). As a class, acyl halides react readily with water to yield the parent acid and hydrogen halide(3-4). Therefore, acrylyl chloride is expected to undergo rapid hydrolysis in the environment(SRC). Acrylyl chloride contains chromophores that absorb at wavelengths >290 nm(5) and, therefore, may be susceptible to direct photolysis by sunlight(SRC).

According to the 2012 TSCA Inventory Update Reporting data, 1 reporting facility estimated the number of persons reasonably likely to be exposed during the manufacturing, processing, or use of acrylyl chloride in the United States may be as low as <10 workers per plant; the data may be greatly underestimated due to confidential business information (CBI) or unknown values(1).

Occupational exposure to acrylyl chloride may occur through inhalation and dermal contact with this compound at workplaces where acrylyl chloride is produced or used. (SRC)

Releases of CERCLA hazardous substances are subject to the release reporting requirement of CERCLA section 103, codified at 40 CFR part 302, in addition to the requirements of 40 CFR part 355. Acrylyl chloride is an extremely hazardous substance (EHS) subject to reporting requirements when stored in amounts in excess of its threshold planning quantity (TPQ) of 100 lbs.

Acrylyl chloride

1

10000

Flammable chemical that can be released at a facility.