Diethyl Ether → N-(6,6-dimethylbicyclo[3.1.1]hept-2-yl)-2-propenamide

HRID 5496

反応式

HRID 5496 の反応式
[C:1](Cl)(=[O:4])[CH:2]=[CH2:3].C([N:8]([CH2:11][CH3:12])CC)C.[C:13]12(N)[CH2:19][CH:17]([CH2:18]1)[CH2:16][CH2:15]C2.[CH2:21](OCC)C>>[CH3:21][C:16]1([CH3:15])[CH:12]2[CH2:18][CH:17]1[CH2:19][CH2:13][CH:11]2[NH:8][C:1](=[O:4])[CH:2]=[CH2:3]

参加物

5

反応物 4

HCID 3283Diethyl Ether2 回HCID 8471TriethylamineHCID 13140Acryloyl chlorideHCID 15730006Bicyclo[3.1.1]heptan-1-amine

生成物 1

HCID 19795927N-(6,6-dimethylbicyclo[3.1.1]hept-2-yl)-2-propenamide

実験手順

Following the procedure of Example 3, a solution of acryloyl chloride (4.05 ml, 0.05 mole) in ethyl ether (50 ml) was added dropwise to a cold 5° C. mixture of triethylamine (15.3 ml, 0.11 mole) and norpinylamine (6.96; g, 0.05 mole) in ethyl ether (400 ml). The reaction was allowed to warm to room temperature and stirred for 72 hours. The light tan solid was filtered and washed well with ethyl ether. The solvent and triethylamine were removed, leaving the title product as an oily solid. The structure was confirmed by NMR.

後処理

  1. filtrationThe light tan solid was filtered
  2. washwashed well with ethyl ether
  3. customThe solvent and triethylamine were removed

出典と根拠

ORDレコード
ord-0c853584f40147fcac7748a5dc4bc09f
出典データセット
uspto-grants-1993_09
特許番号
US05244899

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