基本情報
- 標準SMILES
O=C([O-])CC(O)(CC(=O)[O-])C(=O)[O-].[K+].[K+].[K+]- InChIKey
QEEAPRPFLLJWCF-UHFFFAOYSA-K- 分子式
- C6H5K3O7
- 平均分子量
- 306.39 g/mol
- 単同位体質量
- 305.8946469
名称と識別子
- 優先名称
- Tripotassium citrate
- IUPAC
- tripotassium;2-hydroxypropane-1,2,3-tricarboxylate
名称と別名
TRIPOTASSIUM CITRATE866-84-2KaliksirPotassium citrate anhydrousLitocitPorekalKajosUrocit KSeltz-KK citrateCitric acid, tripotassium saltPotassium tribasic citrate
名称をさらに表示
ACALKA86R1NVR0HW1,2,3-Propanetricarboxylic acid, 2-hydroxy-, tripotassium saltDTXSID8027325RefChem:933490Anhydrous, Potassium CitrateDTXCID907325212-755-5
データベース識別子
- CAS
7778-49-6、866-84-2- PubChem CID
- 13344
- DTXSID
DTXSID8027325- ChEMBL
CHEMBL1200458- ChEBI
CHEBI:64733- UNII
- 86R1NVR0HW
- EC Number
- 212-755-5、231-905-0
- Nikkaji
- J7.148J
物性
構造計算による物性
- 極性表面積
- 141 Ų
- 水素結合供与体数
- 1
- 水素結合受容体数
- 7
- 回転可能結合数
- 2
- 重原子数
- 16
- 形式電荷
- 0
- 複雑度
- 211
実験および物理化学的性質
pH
Between 7,5 and 9,0 (5 % aqueous solution)
THE AQ SOLN IS ALKALINE TO LITMUS; PH ABOUT 8.5
OdorODORLESS
TasteHAS COOLING, SALINE TASTE
Density1.98 @25 °C
Color/Form
WHITE CRYSTALS, GRANULES, OR POWDER
TRANSPARENT CRYSTALS
Solubility
1 G DISSOLVES IN 0.65 ML WATER
1 G DISSOLVES VERY SLOWLY IN 2.5 ML GLYCEROL
ALMOST INSOL IN ALCOHOL
Physical Description
Liquid
Liquid; Large Crystals; Dry Powder
White, hygroscopic, granular powder or transparent crystals
Monohydrate: White odorless solid; [Merck Index] White odorless crystalline granules; [MSDSonline]
Other Experimental PropertiesLOSES WATER AT 180 °C
安全と法規制
GHS分類
GHS Classification
This chemical does not meet GHS hazard criteria for 96.3% (572 of 594) of all reports.
Not Classified；Reported as not meeting GHS hazard criteria by 572 of 594 companies (only 3.7% companies provided GHS information). For more detailed information, please visit ECHA C&L website.
Aggregated GHS information provided per 594 reports by companies from 4 notifications to the ECHA C&L Inventory.；Reported as not meeting GHS hazard criteria per 572 of 594 reports by companies.；There are 2 notifications provided by 22 of 594 reports by companies with hazard statement code(s).；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.
This chemical does not meet GHS hazard criteria for 100% (14 of 14) of all reports.
Not Classified；Reported as not meeting GHS hazard criteria by 14 of 14 companies. For more detailed information, please visit ECHA C&L website.
Aggregated GHS information provided per 14 reports by companies from 2 notifications to the ECHA C&L Inventory.；Reported as not meeting GHS hazard criteria per 14 of 14 reports by companies.；There are 0 notifications provided by 0 of 14 reports by companies with hazard statement code(s).；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.
危険有害性情報
Regulatory Information
Chemical: 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, tripotassium salt
1,2,3-Propanetricarboxylic acid, 2-hydroxy-, potassium salt (1:?) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, potassium salt (1:?) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
1,2,3-Propanetricarboxylic acid, 2-hydroxy-, potassium salt (1:3) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, potassium salt (1:3) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
Status: Active Update: 19-12-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/14309
1,2,3-Propanetricarboxylic acid, 2-hydroxy-, tripotassium salt: Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationIMAP assessments - 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, tripotassium salt: Human health tier I assessment
Hazards SummaryPotassium salts by mouth in doses less than 2 mEq/kg are usually not toxic in patients with normal renal function; [HSDB] May cause irritation; [MSDSonline]
FDA Requirements121.101; LIMITATIONS: GRAS SEQUESTRANT; GRAS MISCELLANEOUS AND/OR GENERAL-PURPOSE FOOD ADDITIVE.
EPA Safer ChemicalChemical: Potassium citrate, anhydrous； Green circle - The chemical has been verified to be of low concern based on experimental and modeled data.
Hazard Classes and Categories
Not Classified
Not Classified
安全と保護具
Protective Action Criteria (PAC)
2.1 [mg/m3]
23 [mg/m3]
140 [mg/m3]
毒性情報
Interactions12 OF 40 HEART PT TREATED WITH POTASSIUM CITRATE SHOWED SLIGHT MALABSORPTION OF VITAMIN B12. MECHANISM OF THE DISTURBANCE APPEARED TO BE ACIDIFICATION OF CONTENTS OF THE ILEUM.
Human Toxicity ExcerptsCONGENITAL MALFORMATIONS AND SURVIVAL IN RELATION TO THE FIRST TRIMESTER USE OF SPECIFIC DRUGS AND VACCINES ARE PRESENTED.
法規制情報
Regulatory Information
Chemical: 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, tripotassium salt
1,2,3-Propanetricarboxylic acid, 2-hydroxy-, potassium salt (1:?) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, potassium salt (1:?) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
1,2,3-Propanetricarboxylic acid, 2-hydroxy-, potassium salt (1:3) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, potassium salt (1:3) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
Status: Active Update: 19-12-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/14309
1,2,3-Propanetricarboxylic acid, 2-hydroxy-, tripotassium salt: Does not have an individual approval but may be used under an appropriate group standard
FDA Requirements121.101; LIMITATIONS: GRAS SEQUESTRANT; GRAS MISCELLANEOUS AND/OR GENERAL-PURPOSE FOOD ADDITIVE.
化学と産業
薬理情報
FDA Pharmacological Classification
86R1NVR0HW
POTASSIUM CITRATE ANHYDROUS
Mechanisms of Action [MoA] - Alkalinizing Activity
Established Pharmacologic Class [EPC] - Metabolic Alkalinizer
Potassium citrate anhydrous is a Metabolic Alkalinizer. The mechanism of action of potassium citrate anhydrous is as an Alkalinizing Activity.
MeSH Pharmacological Classification
Agents that promote the excretion of urine through their effects on kidney function.
Agents that increase mucous excretion. Mucolytic agents, that is drugs that liquefy mucous secretions, are also included here.
用途と製造
Uses
Used as a food additive (sequestrant, stabilizer, and buffer), a preservative for cut flowers, and a medication (potassium supplement, diuretic, expectorant, and alkalizer); [HSDB] Used as chemical intermediate; [MSDSonline]
MEDICATION
MEDICATION (VET)
SEQUESTRANT FOOD ADDITIVE
STABILIZER, BUFFER IN FOODS
IN PRESERVATION OF CUT FLOWERS
U.S. Production
2023: 75,000 - <100,000 lb；2022: 75,000 - <100,000 lb；2021: 75,000 - <100,000 lb；2020: 50,000 - <250,000 lb
2023: 1,000,000 - <2,500,000 lb；2022: 2,500,000 - <4,000,000 lb；2021: 2,500,000 - <4,000,000 lb；2020: 1,000,000 - <2,500,000 lb
Consumer UsesSoil amendments (fertilizers)；Emulsifier
Industry UsespH regulating agent；Soil amendments (fertilizers)；Emulsifier
Methods of ManufacturingBY ADDING POTASSIUM BICARBONATE OR CARBONATE TO A SOLN OF CITRIC ACID UNTIL EFFERVESCENCE CEASES, FILTERING THE SOLN & EVAPORATION TO GRANULATION.
Formulations/Preparations
POTASSIUM CITRATE, NF. POWDER, NF. TABLETS, 2.3 MEQ OF K+ AND 0.8 MEQ OF C6H5O7(3-) (250 MG), 2.8 MEQ OF K+ AND 0.9 MEQ OF C6H5O7(3-) (300 MG), AND 5.6 MEQ OF K+ AND 1.8 MEQ OF C6H5O7(3-) (600 MG).
IT IS AT LEAST 99% PURE.
GRADES: TECHNICAL; CP; NF; FCC.
Household ProductsInformation on 2 consumer products that contain Potassium Citrate in the following categories is provided:；• Commercial / Institutional
Use Classification
EPA Safer Chemical Functional Use Classes -> Chelating Agents;Processing Aids and Additives
Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern
Food additives
Fragrance Ingredients
Food Additives -> ACIDITY_REGULATOR; SEQUESTRANT; STABILIZER -> JECFA Functional Classes
Food Additives -> ACIDITY_REGULATOR; SEQUESTRANT; STABILIZER -> JECFA Functional Classes
General Manufacturing Information
Other (requires additional information)；Pesticide, Fertilizer, and Other Agricultural Chemical Manufacturing；Soap, Cleaning Compound, and Toilet Preparation Manufacturing
1,2,3-Propanetricarboxylic acid, 2-hydroxy-, potassium salt (1:3): ACTIVE
1,2,3-Propanetricarboxylic acid, 2-hydroxy-, potassium salt (1:?): ACTIVE
INCOMPATIBILITIES: AQUEOUS SOLUTIONS...WILL REACT WITH ACIDIC SUBSTANCES. ALKALOIDAL SALTS MAY BE PPT FROM...AQ OR HYDROALCOHOLIC SOLN. ACIDIFICATION OR ADDITION OF ALCOHOL WILL RESTORE SOLN. CALCIUM & STRONTIUM SALTS CAUSE PRECIPITATION OF CORRESPONDING CITRATES.
関連反応
21 件
関連ノート
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