Laurolactam (HCID 13690)

概要

Laurolactam is a keratan 6'-sulfate and an azamacrocycle.

名称と識別子

優先名称: Laurolactam
IUPAC: azacyclotridecan-2-one
英語名: NYLON 12
分子式: C36H69N3O3X2
分子量: 197.32

名称と別名

Azacyclotridecan-2-one947-04-6LaurolactamLauryl lactamDodecyllactamLaurinolactamLaurin lactamomega-LaurolactamCYCLODODECALACTAMDodecanolactam2-Oxo-dodecamethylenimine1-Aza-2-cyclotridecanone

名称をさらに表示

Polyamide12NYLON 12 ISO 9001：2015 REACHNtylon-12POLYLAURYLLACTAMLauryl lactam, homopolymerazacyclotridecan-2-one,homopolymerAzacyclotridecane-2-one,homopolymer

omega-Dodecalactamomega-DodecanolactamDodecanoic acid, 12-amino-, lactamDTXSID1027344UB8VFC953GNSC-77100DTXCID107344RefChem:7697

データベース識別子

CAS: 25038-74-8、947-04-6
PubChem CID: 13690
DTXSID: DTXSID1027344
ChEMBL: CHEMBL3181948
ChEBI: CHEBI:172332
UNII: UB8VFC953G
EC Number: 213-424-8
Nikkaji: J12.504K

物性

構造計算による物性

XLogP: 2.8
極性表面積: 29.1 Å²
水素結合供与体数: 1
水素結合受容体数: 1
回転可能結合数: 0
重原子数: 14
形式電荷: 0
複雑度: 156

実験および物理化学的性質

PolymersPlastics & Rubber -> Other Monomers

SpringerMaterials Properties15N nuclear magnetic resonance spectrum

SolubilityVIRTUALLY INSOL IN WATER

Vapor Pressure0.00000731 [mmHg]

Food Contact Substances · 2 件

FCS -> FDA Cumulative Estimated Daily Intake (CEDI)

FCS -> FDA Inventory of Food Contact Substances Listed in 21 CFR

Physical Description · 2 件

Dry Powder; Large Crystals

Solid; [eChemPortal: SIDSUNEP] Very faintly beige crystalline lumps; [MSDSonline]

物理化学的性質

融点: 176 °C · 176 °C
比重(密度): 1.01 g/mL · 1.01 g/mL at 25 °C(lit.)
外見: ペレット
化粧品成分の機能: 増量剤粘度制御不透明剤
LogP: 3.123 · 3.123 (est)
EPAの化学物質情報: -2 · Azacyclotridecan-2-one, homopolymer (25038-74-8)

安全と法規制

GHS分類

GHS Classification · 6 件

This chemical does not meet GHS hazard criteria for 96.6% (115 of 119) of all reports.

Not Classified

Aggregated GHS information provided per 119 reports by companies from 2 notifications to the ECHA C&L Inventory.

Warning

H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure]

P260, P264, P270, P273, P308+P316, P405, and P501 (click each P-code to see the statement)

危険有害性情報

Regulatory Information · 3 件

Chemical: Azacyclotridecan-2-one

Azacyclotridecan-2-one is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Azacyclotridecan-2-one are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 12-04-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/13738

Hazards SummaryMay cause irritation; [MSDSonline] See Caprolactam.

Hazard Classes and Categories · 2 件

Not Classified

Specific target organ toxicity - Single exposure - Category 2 (central nervous system, digestive system)

毒性情報

Non-Human Toxicity Excerpts · 2 件

ALL THE THIOLACTAMS STUDIED CAUSED CLONIC AND TONIC CONVULSIONS IN MICE A FEW SEC AFTER IP ADMIN. THE VARIATION IN THE ACUTE BASAL TOXICITY OF THE THIOLACTAMS WAS MAINLY DUE TO THE CHANGE IN THE LIPOHYDROPHILIC CHARACTER. THE DIPOLE MOMENT APPEARS TO PLAY A SIGNIFICANT ROLE IN DETERMINING THE CONVULSANT ACTIVITY IN THE TOXICITY OF THIOLACTAMS, LACTAMS, & GAMMA-THIOBUTYROLACTONE.

FOR LACTAMS WITH SMALL RING SIZE, CNS STIMULATION APPEARED TO BE DOMINANT IN MICE THAT WERE INJECTED IP WITH A SERIES OF LOGARITHMIC DOSES (30, 100, 300, AND 1000 MG/KG (GROUPS OF 6 ANIMALS, 3 MALES & 3 FEMALES). 2-AZACYCLOTRIDECANONE CAUSED TREMBLING AT 500 MG/KG IN 6/6 MICE.

安全データ

wgk: 3
tsca: TSCA listed

化学と産業

用途と製造

UsesUsed as a monomer for the polymerization of polyamide; [eChemPortal: SIDSUNEP]

U.S. Production2023: 8,500,000 - <25,000,000 lb

Industry UsesMonomers

General Manufacturing Information · 2 件

Plastics Product Manufacturing

Azacyclotridecan-2-one: ACTIVE

応用分野

使用nylon 12 is a bulking and opacifying agent that provides good feel and good elasticity to moisturizers and makeup preparations, including foundations. nylon 12 reduces oiliness. It is a polyamide derivative of acid 12-aminododecanioic.

調製方法 · 1 件

製造方法Nylon 12 is produced by heating dodecyl lactam at about 300°C in the presence of aqueous phosphoric acid. The polymerization of dodecyllactam does not involve an equilibrium reaction (unlike the polymerization of caprolactam) and hence an almost quantitative yield of polymer is obtained and the removal of low molecular weight material is unnecessary.