2-Amino-6-methylpyridine (HCID 15765)

名称と識別子

優先名称: 2-Amino-6-methylpyridine
IUPAC: 6-methylpyridin-2-amine
現地名: 6-アミノ-2-ピコリン
英語名: 2-Amino-6-methylpyridine
分子式: C6H8N2
分子量: 108.14

名称と別名

2-Amino-6-methylpyridine6-methylpyridin-2-amine2-Amino-6-picoline2-Pyridinamine, 6-methyl-6-Methyl-2-pyridinamine6-Methyl-2-pyridylamine2-Picoline, 6-amino-6-Amino-2-methylpyridine6-Methyl-2-aminopyridinePYRIDINE, 2-AMINO-6-METHYL-NSC 6971NSC 1488

名称をさらに表示

6-アミノ-2-ピコリン6-メチルピリジン-2-アミン2-アミノ-6-ピコリン2-メチル-6-アミノピリジン2-アミノ-6-メチルピリジン6-メチル-2-ピリジンアミン6-メチル-2-ピリジニルアミン2アミノ6メチルピリジンピコリンメチルピリジン6-アミノ-Α-ピコリン2‐アミノ‐6‐ピコリン2‐アミノ‐6‐メチルピリジン6-AMINO-2-PICOLINE2A6PCAKOS 91157AKOS BBS-00004344TIMTEC-BB SBB0043552-Amino-6-methylpyri6-methyl-2-pyridinamin

DTXSID0044860UNII-35ANN6MRBM35ANN6MRBM2-amino-6-methyl pyridineEINECS 217-360-1BRN 0107048AI3-24112NSC-1488

データベース識別子

CAS: 1824-81-3
PubChem CID: 15765
DTXSID: DTXSID0044860
ChEMBL: CHEMBL61591
UNII: 35ANN6MRBM
EC Number: 217-360-1
Nikkaji: J38.381C

物性

構造計算による物性

XLogP: 0.4
極性表面積: 38.9 Å²
水素結合供与体数: 1
水素結合受容体数: 2
回転可能結合数: 0
重原子数: 8
形式電荷: 0
複雑度: 72

実験および物理化学的性質

Kovats Retention Index · 2 件

1074

1893

Collision Cross Section119.5 Å² [M+H]+ [CCS Type: DT; Buffer gas: N2; Ionization: ESI+; Dataset: TOXCAST; Source Identifier: DTXSID0044860]；118.6 Å² [M+H]+ [CCS Type: DT; Buffer gas: N2; Ionization: APCI+; Dataset: TOXCAST; Source Identifier: DTXSID0044860]

物理化学的性質

融点: 40 · 40-44 °C(lit.)
沸点: 208 · 208-209 °C(lit.)
比重(密度): 1.0275 · 1.0275 (estimate)
屈折率: 1.556 · 1.5560 (estimate)
闪点: 218 °F · 218 °F
貯蔵温度: Keep in dark place,Inert atmosphere,Room temperature
酸解離定数(Pka): 1 · pK1: 7.41(+1) (25°C)
外見: 結晶性低融点固体
色: 黄色
水溶解度: 非常にかすかな濁り
BRN: 107048 · 107048
InChI: 1S/C6H8N2/c1-5-3-2-4-6(7)8-5/h2-4H,1H3,(H2,7,8)
InChIKey: QUXLCYFNVNNRBE-UHFFFAOYSA-N
SMILES: Cc1cccc(N)n1
CAS データベース: 1824 · 1824-81-3(CAS DataBase Reference)
NISTの化学物質情報: 2 · 2-Pyridinamine, 6-methyl-(1824-81-3)
EPAの化学物質情報: 2 · 2-Pyridinamine, 6-methyl- (1824-81-3)

化学的性質

化学的特性YELLOWISH CRYSTALLINE LOW MELTING SOLID

安全と法規制

GHS分類

GHS Classification · 5 件

Danger

H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]；H310 (94.8%): Fatal in contact with skin [Danger Acute toxicity, dermal]；H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]；H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]；H335 (98.3%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P261, P262, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P316, P319, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 58 reports by companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

危険有害性情報

Regulatory Information · 2 件

Chemical: 2-Pyridinamine, 6-methyl-

2-Amino-6-methylpyridine: Does not have an individual approval but may be used under an appropriate group standard

Hazard Classes and CategoriesAcute Tox. 3 (100%)；Acute Tox. 2 (94.8%)；Skin Irrit. 2 (100%)；Eye Irrit. 2A (100%)；STOT SE 3 (98.3%)

法規制情報

Regulatory Information · 2 件

Chemical: 2-Pyridinamine, 6-methyl-

2-Amino-6-methylpyridine: Does not have an individual approval but may be used under an appropriate group standard

安全データ

F: 10-21
wgk: 3
tsca: TSCA listed
rtecs: US1885000
ridadr: UN 2811 6.1/PG 3
hs_code: 29333999
risk_code: 25-36/37/38-24/25-23/24/25-24
化審法: (9)-117
hazard_code: T
safety_code: 26-36/37/39-45-37/39-28A
hazard_class: 6.1
packing_group: II
Hazard Classifications: Acute Tox. 2 DermalAcute Tox. 3 OralEye Irrit. 2Skin Irrit. 2STOT SE 3
ストレージクラス: 6.1A - Combustible acute toxic Cat. 1 and 2very toxic hazardous materials

化学と産業

用途と製造

General Manufacturing Information2-Pyridinamine, 6-methyl-: ACTIVE

応用分野 · 3 件

用途有機合成原料。

使用Intermediate.

使用2-Amino-6-methylpyridine is a reagent used in the identification of selective inhibitor for phosphatidylinositol 3-kinase (PI3Ka).

調製方法 · 1 件

純化方法Crystallise it three times from acetone and dry it under vacuum at ca 45o. Alternatively, keep it in contact with NaOH pellets for 3hours, with occasional shaking, decant and fractionally distil it [Mod et al. J Phys Chem 60 1651 1956]. It also recrystallises from CH2Cl2 on addition of pet ether. [Marzilli et al. J Am Chem Soc 108 4830 1986, Beilstein 22/9 V 210.]

上流・下流製品情報

上流原料

4-クロロベンズアルデヒド 2-ピコリンナトリウム三硝酸鉄(III)アンモニア 6-ブロモ-2-ピコリンヨウ化銅アセトニトリルアンモニア水

下流製品

6-フルオロ-2-ピコリン 2-Amino-6-nitropyridine 6-フルオロピコリン酸 6-ヒドロキシ-2-メチル-3-ニトロピリジン 2-Chloro-5-fluoropyridine-6-carboxylic acid 3-Bromo-6-chloro-2-methyl-5-nitropyridine 6-(Acetylamino)-2-pyridinecarboxylic acid 6-アミノ-3-ニトロ-2-ピコリン 6-Methyl-pyridine-2,5-diamine 6-Nitropyridine-2-carboxylic acid ethyl ester 2-Isocyanato-6-nitropyridine 3-Amino-6-methoxypyridine-2-carboxylic acid

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6-アミノ-2-ピコリン

基本情報