2-Amino-6-methylpyridine → 2-chloro-5-fluoro-N4-(6-methylpyridin-2-yl)-4-pyrimidineamine

HRID 76413

反応式

HRID 76413 の反応式
[Cl:1][C:2]1[N:7]=[C:6](Cl)[C:5]([F:9])=[CH:4][N:3]=1.[NH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([CH3:17])[N:12]=1>>[Cl:1][C:2]1[N:7]=[C:6]([NH:10][C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([CH3:17])[N:12]=2)[C:5]([F:9])=[CH:4][N:3]=1

参加物

3

反応物 2

HCID 157652-Amino-6-methylpyridineHCID 2507052,4-Dichloro-5-fluoropyrimidine

生成物 1

HCID 220605432-chloro-5-fluoro-N4-(6-methylpyridin-2-yl)-4-pyrimidineamine

実験手順

In like manner to the preparation of 2-chloro-5-fluoro-N4-[3-(1H-tetrazol-5-yl)phenyl]-4-pyrimidineamine the reaction of 2,4-dichloro-5-fluoropyrimidine with 2-amino-6-methylpyridine gave 2-chloro-5-fluoro-N4-(6-methylpyridin-2-yl)-4-pyrimidineamine. 1H NMR (CDCl3): δ 8.23 (s, 1H), 8.19 (s, 1H), 8.12 (d, 1H, J=3 Hz), 7.55 (bs, 1H), 7.69 (t, 1H, J=7.4 Hz), 9.35 (d, 1H, J=7.5 Hz); 19F NMR (CDCl3): −44073; LCMS: purity: 96%; MS (m/e): 239 (M+).

後処理

  1. customIn like manner to the preparation of 2-chloro-5-fluoro-N4-[3-(1H-tetrazol-5-yl)phenyl]-4-pyrimidineamine

出典と根拠

ORDレコード
ord-214193e36dc4410780852da34b52210c
出典データセット
uspto-grants-2014_09
特許番号
US08835430B2

関連ノート

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