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HCID 17531作成日：2026年11月2日

ジチオりん酸O,O-ジエチルS-[(4-オキソ-1,2,3-ベンゾトリアジン-3(4H)-イル)メチル]

トリアゾチオン · グチオン-エチル · アジンホスエチル · ジチオりん酸O,O-ジエチルS-[(4-オキソ-1,2,3-ベンゾトリアジン-3(4H)-イル)メチル] · グサチオンA · エチルグチオン · アジンホス－エチル · アジンホスエチル標準品

https://huagongshe.com/ja/chemical/17531

ジチオりん酸O,O-ジエチルS-[(4-オキソ-1,2,3-ベンゾトリアジン-3(4H)-イル)メチル] の分子構造式

識別子と物理属性

CAS No.2642-71-9
分子式C12H16N3O3PS2
平均分子量345.4 g/mol
単同位体質量345.03707073 g/mol
SMILESCCOP(=S)(OCC)SCn1nnc2ccccc2c1=O
InChIKeyRQVGAIADHNPSME-UHFFFAOYSA-N
PubChem CID17531
ChEMBLCHEMBL1886341
ChEBICHEBI:38587
EC No.220-147-6
DTXSIDDTXSID5037498
現地名ジチオりん酸O,O-ジエチルS-[(4-オキソ-1,2,3-ベンゾトリアジン-3(4H)-イル)メチル]

化学・物理的性質

XLogP3.4
極性表面積121
水素結合供与体数0
水素結合受容体数7
回転可能結合数7
重原子数21
形式電荷0
複雑度439
SpringerMaterials PropertiesFusion temperature
農薬Acaricides, InsecticidesActive substance -> EU Pesticides database: Not approvedPesticides -> Organophosphate InsecticidesPesticide (Azinphos ethyl) -> USDA PDB
LogP（分配係数）log Kow = 3.40
密度1.284 at 68 °F (EPA, 1998) - Denser than waterwill sink1.284 c/cu cm at 20 °C1.284 @ 20°C1.43
Color/FormColorless needles
溶解度SOL IN ORG SOLVENTS EXCEPT PETROLEUM ETHER AND ALIPHATIC HYDROCARBONSAt 20 °C: n-hexane, 2-5 g/Lisopropanol, 20-50 g/Ldichloromethane, >1,000 g/Ltoluene, >1,000 g/LSoluble in 2-propanol.In water, 10.5 mg/L at 20 °C4.5 mg l-1 (20 °C)
CorrosivityNon-corrosive
沸点232 °F at 0.001 mmHg (EPA, 1998)BP: 111 °C at 0.001 mm Hg111°C
DecompositionWhen heated to decomposition it emits very toxic fumes of /phosphorous oxides, sulfur oxides, and nitrogen oxides/.
融点127 °F (EPA, 1998)53 °C45-47℃
蒸気圧2.2e-07 mmHg at 68 °F (EPA, 1998)0.0000024 [mmHg]0.32 mPa /2.4X10-6 mm Hg/ at 20 °C0.0000032 [mm Hg] @20 °C3.2 x 10-4 Pa (20 °C)
屈折率Index of refraction: 1.5928 at 53 °C/DIndex of Refraction: 1.284 @ 20 °C
貯蔵条件0-6°C
pKa（酸解離定数）-2.59±0.20(Predicted)
外観・状態個体
BRN297468
ヘンリー定数1.0×102 mol/(m3Pa) at 25℃, HSDB (2015)
主な用途農業環境
InChI1S/C12H16N3O3PS2/c1-3-17-19(20,18-4-2)21-9-15-12(16)10-7-5-6-8-11(10)13-14-15/h5-8H,3-4,9H2,1-2H3
InChIKeyRQVGAIADHNPSME-UHFFFAOYSA-N
SMILESCCOP(=S)(OCC)SCN1N=Nc2ccccc2C1=O
CAS データベース2642-71-9(CAS DataBase Reference)
EPAの化学物質情報Azinphos-ethyl (2642-71-9)

化学的特性

Azinphos-ethyl forms colorless, clear crystals. It is insoluble in water, but soluble in most organic solvents. As an acaricide, azinphos-ethyl is used for the control of pests, such as, spider mites, aphids, caterpillars, potato bug, beetles, bollweevils, whitefl ies, bollworms, thrips, and other biting and sucking insects. Human exposures to azinphos-ethyl occur through absorption from the gastrointestinal tract, through the intact skin, and by inhalation of fi ne spray mist and dusts. Azinphos-ethyl is a non-systemic organophosphorus insecticide, which is used against a relatively broad spectrum of insects. These include lepidopterous larvae, beetles and their larvae, aphids, jassids, and spider mites on various crops. And also crops of cotton, rice, sugar and fodder beets, fruits such as apples, pears, citrus-fruit, grapes; tobacco. Many countries around the world have stopped the use of this pesticide.

安全性と法規制

GHS 分類DangerH300: Fatal if swallowed [Danger Acute toxicity, oral]P262, P264, P270, P273, P280, P301+P316, P302+P352, P316, P321, P330, P361+P364, P391, P405, and P501 (click each P-code to see the statement)H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]
規制情報95/276/ECThe New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)
その他の安全情報IMAP assessments - Phosphorodithioic acid, O,O-diethyl S-[(4-oxo-1,2,3-benzotriazin-3(4H)-yl)methyl] ester: Environment tier I assessment
輸送ラベル（DOT）Poison
火災危険(Non-Specific -- Organophosphorus Pesticide, n.o.s.) When heated to decomposition, it emits very toxic fumes of sulfur, phosphorus and nitrogen oxides. Container may explode in heat of fire. (EPA, 1998)
健康有害性The systemic effects of this compound are similar to parathion. It is an extremely potent systemic toxicant via ingestion, inhalation and skin contact. It may cause death or permanent injury after very short exposure to small quantities. (EPA, 1998)
有害性の概要Effects in high dose animal studies include depression of cholinesterase activity[HSDB] Extremely toxic cholinesterase inhibitor that may cause death as a result of minor exposure to small amounts[CAMEO] Toxic by ingestion, skin absorption, or inhalation[INCHEM PDS: Azinphos-ethyl - 1994] May cause irritationEffects in high dose animal studies include convulsions[MSDSonline] The average of two baseline respective cholinesterase activity determinations three days apart, with no exposures to enzyme inhibiting pesticides for at least 30 days, is recommended for each worker prior to exposure to cholinesterase inhibitors because of large inter-individual differences in published baseline values. To be established at least once a year. Removal from workplace exposures is recommended until the cholinesterase activity returns to within 20% of baseline. [TLVs and BEIs]
反応性グループAmides and Imides
Special ReportsToxicology Review: Residue Reviews 51: 123 (1974)

用途

使用

Azinphos-ethyl is used to control both chewing and sucking pests on a wide range of crops.

一般的な説明

Colorless crystals. Used as a non-systemic insecticide with good ovicidal properties and long persistence. Used on cotton, citrus, vegetables, potatoes, tobacco, rice, and cereals to control caterpillars, beetles, aphids, spiders and many other insects. Not registered for use in the U.S.

Toxicology Review: Residue Reviews 63: 1 (1976)
WHO
Environ Health Criteria 63: Organophosphorus Insecticides: A General Introduction (1986)
Reactivity ProfileThe BPS Pesticide incident in Helena resulted in an explosion and death of three firemen. The burning of a 1,000 pound sack of Azinphos Methyl or the flashing of Maneb which was present on the facility may have caused the explosion. Azinphos Ethyl may behave similarly. At elevated temperatures, it will decompose generating toxic gases.
DOT Emergency Guidelines/GUIDE 131: FLAMMABLE LIQUIDS-TOXIC/ Health: TOXICmay be fatal if inhaled, ingested or absorbed through skin. Inhalation or contact with some of these materials will irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution. /Organophosphorus pesticide, liquid, flammable, poisonousOrganophosphorus pesticide, liquid, flammable, toxicOrganophosphorus pesticide, liquid, poisonous, flammableOrganophosphorus pesticide, liquid, toxic, flammable//GUIDE 131: FLAMMABLE LIQUIDS-TOXIC/ Fire or Explosion: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion and poison hazard indoors, outdoors or in sewers. Those substances designated with a "P" may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. /Organophosphorus pesticide, liquid, flammable, poisonous/GUIDE 131: FLAMMABLE LIQUIDS-TOXIC/ Public Safety: CALL Emergency Response Telephone Number ... As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering. /Organophosphorus pesticide, liquid, flammable, poisonous/GUIDE 131: FLAMMABLE LIQUIDS-TOXIC/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLYit is not effective in spill situations where direct contact with the substance is possible. /Organophosphorus pesticide, liquid, flammable, poisonousFor more DOT Emergency Guidelines (Complete) data for AZINPHOS ETHYL (16 total), please visit the HSDB record page.
DOT Hazard ClassificationAzinphos-ethylSevere marine pollutant
Air and Water ReactionsNearly insoluble in water. What little amount is solubilized will readily hydrolyze.
消火(Non-Specific -- Organophosphorus Pesticide, n.o.s.) Stay upwindkeep out of low areas. Move containers from fire area if you can do so without risk. Fight fire from maximum distance. Dike fire control water for later disposaldo not scatter the material. Wear positive pressure breathing apparatus and special protective clothing.
応急処置Warning: Effects may be delayed up to 12 hours. Caution is advised.
暴露管理・個人防護Biological Exposure Indices (BEI) [ACGIH] - Acetylcholinesterase activity in red blood cells = 70% of individual's baselineButylcholinesterase activity in serum or plasma = 60% of individual's baselineSample at end of shift[TLVs and BEIs]
消火手順Self contained breathing apparatus with a full facepiece operated in pressure demand, or other positive pressure mode /should be used in firefighting/. /Parathion/If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use "alcohol" foam, dry chemical or carbon dioxide. /Organophosphorus pesticides, liquid, flammable, toxicOrganophosphorus pesticides, liquid, toxic/If material on fire or involved in fire: Use water in flooding quantities as fog. Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use foam, dry chemical, or carbon dioxide. /Organophosphorus pesticides, solid, toxic/
保管条件Store in original container, preferably in locked storage, away from children, food, or feed.Rooms used for storage only should be soundly constructed & fitted with secure locks. Floors should be kept clear & pesticides clearly identified. If repacking is carried out in storage rooms, adequate light should be availablefloors should be impervious & sound ... /Pesticides/Pesticides containers must be provided with labels indicating the degree of toxicity of the product they contain. The labels must not only give a short description of how to use the prepn, but also state basic precautions to be taken when applying it. /Organophosphorus pesticides/Pesticides of any degree of toxicity should be transported in containers which are clearly labelled, leak-proof, and not easily damaged. They should never be transported /or stored/ beside, or above any type of food, and all spillages should be immediately reported. /Pesticides/
清掃方法1. Ventilate area of spill or leak. 2. Collect for reclamation, or absorb in vermiculite, dry sand, earth, or a similar material. /parathion/Spills of parathion on floors ... absorbed with an absorbing clay. Sweeping compound ... facilitate the removal of all visible traces of parathion contaminated clay. /Parathion/Environmental considerations: Air spill: Apply water spray or mist to knock down vapors. /Organophosphorus pesticides, liquid, flammable, toxicOrganophosphorus pesticides, liquid, toxicOrganophosphorus pesticides, solid, toxic/Environmental considerations: Water spill: Use natural barriers or oil spill control booms to limit spill travel. Remove trapped material with suction hoses. /Organophosphorus pesticides, liquid, flammable, toxicEnvironmental considerations: Land spill: Dig a pit, pond, lagoon, holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete. Absorb bulk liquid with fly ash, cement powder, or commercial sorbents. /Organophosphorus pesticides, liquid, flammable, toxic
非火災時の漏出対応(Non-Specific -- Organophosphorus Pesticide, n.o.s.) Stay upwindkeep out of low areas. Ventilate closed spaces before entering them. Do not touch spilled materialstop leak if you can do so without risk. Use water spray to reduce vapors.
処分方法SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in soil or watereffects on animal and plant lifeand conformance with environmental and public health regulations.SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.Peer-review: This highly toxic material is rapidly hydrolyzed by cold alkali. Use 5 parts by volume 4% wt/vol sodium hydroxide soln to 1 volume of pesticide. Hydrolysis is improved by making the sodium hydroxide soln in 50% ethanol. Use much water to wash reaction mixture down to sewer. Large amt - incinerate in a unit with effluent gas scrubbing. (Peer-review conclusions of an IRPTC expert consultation (May 1985))Potential candidate for rotary kiln incineration, with a temperature range of 820 to 1,600 °C and a residence time of seconds. Also, a potential candidate for fluidized bed incineration, with a temperature range of 450 to 980 °C, and a residence time of seconds. Also, a potential candidate for liquid injection incineration with a temperature range of 650 to 1,600 °C, and a residence time of 0.1 to 2 seconds. /Parathion/The following wastewater treatment technologies have been investigated for parathion: Reverse osmosis. /Parathion/
Preventive MeasuresA portion of even the most flammable materials is likely to be lost by vaporization. ... The smoke from an open fire used to destroy pesticides will contain some of the poison. Burning should be attempted only in an isolated place. Inhalation of smoke must be avoided. /Pesticides/SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. The completeness of the cleaning procedures should be considered before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at the end of shift, but should remain at employee's place of work for cleaning.... Keep away from heat and open flame.Special aircraft should preferably be used for spraying or dusting toxic organophosphorus pesticides. ... Aerial spraying or dusting gives rise to clouds which spread over larger surfaces than clouds produced by ground application. Aerial spraying should therefore be carried out on windless days only. Residential areas, water supply sources, etc must be avoided. ... When aircraft approaches, signalmen /guiding the aircraft/ should leave the windward side. ... The local population should be informed about the site & time of aerial pesticide treatment. Access of unauthorized persons & especially children to the area to be treated must be ... forbidden. Warning signs should be placed at the limits of the area. Ground spraying must be carried out with compressed-air spraying equipment towed by tractors with closed cabs. /Organophosphorus pesticides/For more Preventive Measures (Complete) data for AZINPHOS ETHYL (14 total), please visit the HSDB record page.
Isolation and EvacuationExcerpt from ERG Guide 152 [Substances - Toxic (Combustible)]:
Protective Action Criteria (PAC)0.075 [mg/m3]0.83 [mg/m3]5.0 [mg/m3]
Personal Protective Equipment (PPE)For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. (EPA, 1998)Rubber gloves, gas mask or respirator, rubber boots, thick long-sleeved shirt/jacket, long pants.NEOPRENE COATED GLOVESRUBBER WORKSHOES OR OVERSHOESLATEX RUBBER APRONGOGGLESRESPIRATOR OR MASK APPROVED FOR TOXIC DUSTS & ORGANIC VAPORS. /PARATHION/Employees should be provided with and required to use impervious clothing, gloves, face shields (eight inch minimum), and other appropriate protective clothing necessary to prevent repeated, or prolonged skin contact with parathion. /Parathion/Respiratory protection (supplied-air respirator with full facepiece or self-contained breathing apparatus) should be available where these compounds are manufactured or used and should be worn in case of emergency and overexposure. /Phosphorus compounds/For more Personal Protective Equipment (PPE) (Complete) data for AZINPHOS ETHYL (6 total), please visit the HSDB record page.
相互作用Pretreatment with piperonyl butoxide (400 mg/kg) 1 hr prior to challenge potentiates the toxicity of ethyl guthion.Some phenothiazines may antagonize & some may potentiate the toxic anticholinesterase effects of ... /organophosphorus insecticides/. /Organophosphate cholinesterase inhibitors/In long term therapy, adrenocorticoids antagonize the antiglaucoma effects of anticholinesterases (incr ocular pressure). ... Anticholinergics antagonize the miotic (antiglaucoma) & other muscarinic effects of anticholinesterases on the autonomic & central nervous systems. Tricyclic antidepressants (anticholinergic effects) antagonize the antiglaucoma (miotic) effects of anticholinesterases in glaucoma. ... Antihistamines with anticholinergic effects antagonize the miotic (antiglaucoma) & CNS effects of anticholinesterases. Anticholinesterases potentiate tranquilizing & behavioral changes induced by antihistamines. The actions of anticholinesterase agents on autonomic effector cells, & to some extent those on CNS, are antagonized by atropine, an antidote of choice. Barbiturates are potentiated by anticholinesterases. ... Dexpanthenol potentiates the effects of anticholinesterases. Fluorophosphate insecticides potentiate the effects of other anticholinesterases. /Anticholinesterases/Barbiturates are potentiated by anticholinesterases. Although barbiturates may be used cautiously in treating convulsions, extreme care is essential in handling poisonings due to anticholinesterases, particularly organophosphorus pesticides. Echothiophate, a cholinesterase inhibitor used as miotic, potentiates other such inhibitors... used for other purposes (additive effects) or possibly synergistic. Those exposed to organophosphate insecticides must take strict precautions. ...Organophosphorus insecticides: additive anticholinesterase effects. Hazardous. Patients on anticholinesterases (even topical, such as eye drops) should avoid areas where organophosphorus insecticides... recently... used. /Anticholinesterase/For more Interactions (Complete) data for AZINPHOS ETHYL (8 total), please visit the HSDB record page.
生態毒性値EC50Species: Daphnia magna (Water Flea) 1st instar larvaeConditions: freshwater, static, 21 °C, pH 7.1, hardness 44 mg/L CaCO3Concentration: 4 ug/L for 48 hr (95% confidence interval: 3-5.3 ug/L)Effect: intoxication, immobilization /88% purity technical material/Species: Simocephalus (Water Flea), first instarConditions: Static bioassay without aeration, 15 °C, pH 7.2-7.5, water hardness 40-50 mg/L as calcium carbonate and alkalinity of 30-35 mg/LConcentration: 4.2 ug/L for 48 hr (95% confidence limit 2.9-6.1 ug/L)Effect: immobilization /Technical, 88%/Species: Daphnia pulex (Water Flea), first instarConcentration: 3.2 ug/L for 48 hr (95% confidence limit 1.8-5.8 ug/L)LC50Species: Pteronarcys(Stonefly), second year classConcentration: 1.5 ug/L for 96 hr (95% confidence limit 0.8-2.7 ug/l) /Technical, 88%/For more Ecotoxicity Values (Complete) data for AZINPHOS ETHYL (10 total), please visit the HSDB record page.
環境中動態TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 170(SRC), determined from a structure estimation method(2), indicates that azinphos ethyl is expected to have moderate mobility in soil(SRC). Volatilization of azinphos ethyl from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 9.9X10-8 atm-cu m/mole(SRC), based upon its vapor pressure, 2.4X10-6 mm Hg(3), and water solubility, 10.5 mg/L(4). Azinphos ethyl is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(3). Degradation of organophosphorothioate pesticides by photooxidation under ultraviolet or sunlight radiation at the soil surface may result in the formation of sulfoxides and trialkyl phosphorothioates(5). The methyl analogue, azinphos methyl, biodegraded in laboratory tests and in soil(6,7) which suggests that azinphos ethyl would also be degraded in the environment(SRC).AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 170(SRC), determined from a structure estimation method(2), indicates that azinphos ethyl is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 9.9X10-8 atm-cu m/mole(SRC), derived from its vapor pressure, 2.4X10-6 mm Hg(4), and water solubility, 10.5 mg/L(5). According to a classification scheme(6), an estimated BCF of 80(SRC), from its log Kow of 3.40(7) and a regression-derived equation(8), suggests the potential for bioconcentration in aquatic organisms is moderate(SRC). Hydrolysis half-life for azinphos ethyl was measured as 173 days at pH 6.1 and 22 °C(9). Photodegradation in aqueous environmental conditions is expected to be the most important process based on studies showing the half-life of azinphos ethyl in river water (pH 7.3) and in seawater (pH 8.1) was 9 and 11 days, respectively, when exposed to lightat 22 °C in the dark half-lives were 65 and 58 days, respectively(10).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), azinphos ethyl, which has a vapor pressure of 2.4X10-6 mm Hg at 20 °C(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase azinphos ethyl is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 2 hours(SRC), calculated from its rate constant of 1.9X10-10 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Particulate-phase azinphos ethyl may be removed from the air by wet or dry deposition(SRC). Azinphos ethyl contains chromophores that absorb at wavelengths >290 nm(4) and, therefore, may be susceptible to direct photolysis by sunlight(SRC).
食品調査値Azinphos ethyl residues were not found on 13,960 food samples analyzed by state agencies in 6 states in 1988(1). Azinphos ethyl residue was detected on 6 of 13,085 (0.045%) samples of food analyzed by state agencies in 10 states in 1989(1). A small sample of the food analyzed was imported from Mexico, Central America, and the Caribbean(1) and since azinphos ethyl is not sold in the US, it is presumed that the residues were found on the imported food. Azinphos ethyl was detected in 20 pasta samples collected in Rome, Italy in 1990 at an average concentration of 0.9 ug/kg (range not detected to 4.5 ug/kg)(2). Azinphos ethyl was not detected (detection limit 0.05 mg/kg) in 10 ready-to-eat packed table olive samples or 30 commercially packed olive oil samples analyzed from 1991-1992 in Greece(3). Azinphos ethyl was detected 2 of 2223 fruit and vegetable samples at 0.05 to 1.00 mg/kg (positive detections were in cucumber and green bean), samples were collected from Brazilian Sao Paulo General Storage and Wholesale over the period of Jan 1994 to Dec 2001(4). Azinphos ethyl was not detected (detection limit 5 ug/kg) in 298 raw milk samples obtained directly from tank trucks during delivery at nine Italian dairy plants, sampling took place Oct 2004, Jan and May 2005(5).
有害作用Other Poison - Organophosphate
Milk ConcentrationsAzinphos ethyl was not detected (detection limit 5 ug/kg) in 298 raw milk samples obtained directly from tank trucks during delivery at nine Italian dairy plantssampling took place Oct 2004, Jan and May 2005(1).Many of /the organophosphorus insecticides/ are excreted in the milk ... /Organophosphorus insecticides/
Average Daily IntakeThe average dietary intake of azinphos ethyl for people living in Rome, Italy in 1990 was 0.03 ug/man/day(1). This was derived from the average dietary intake of pasta which had an average concentration of azinphos ethyl of 0.9 ug/kg(1).
Plant ConcentrationsAzinphos ethyl residues were not detected (detection limit 0.01 ppm) in whole grains, leaves, and stalks of rice plants at harvest time (day 120) that were treated with azinphos ethyl at 5, 15, 45, and 60 days after planting(1).
Animal ConcentrationsAzinphos ethyl was detected in 2% of honeybee samples at concentrations of 0.020 to 0.094 mg/kg, dead bee samples were collected in bags suspended under beehives (only worker bees were analyzed) in the district of Bologna, Italy(1).
Acute Toxicity LinkChemical: AZINPHOS-ETHYL
Medical SurveillanceWorkers handling & applying pesticides must undergo an annual medical examination at the beginning of each agricultural season. Contraindications /meaning further clinical evaluations/ for work with /organophosphorus pesticides/ are organic diseases of the central nervous system, mental disorders & epilepsy, pronounced endocrine & vegetative disorders, pulmonary tuberculosis, bronchial asthma, chronic respiratory diseases, cardiovascular diseases & circulatory disorders, gastrointestinal diseases (peptic ulcer), gastroenterocolitis, diseases of liver & kidneys, eye diseases (chronic conjunctivitis & keratitis). The blood cholinesterase activity must be determined before work starts. In the event of prolonged work periods, this activity should be determined at intervals of 3-4 days. Persons exhibiting a fall in cholinesterase activity of 25% or more must be transferred to other work where they are not exposed to organophosphorus pesticides until this activity is completely restored. Persons with initial signs of indisposition should /be protected from exposure from/ pesticides. /Organophosphorus pesticides/... Surveillance of workers could be carried out through measurement of blood or urinary levels of the cmpd to which they are exposed, or through measurement of a metabolite. /Organic phosphorus pesticides/The assessment of exposure to the organophosphate pesticides, bromophos and dicrotophos can be accomplished through measurement of these compounds in the blood. However, since organophosphate pesticides are rapidly cleared from the blood, it is difficult to be able to detect the pesticides in blood unless very large quantities have been absorbed. This test may be useful for identification of the compound in cases of severe exposure, although documented tests for measurement of specific organophosphate pesticides in blood are very limited. Whole Blood Reference Ranges: Normal - none detectedExposed - not establishedToxic -not established. Serum or Plasma Reference Ranges: Normal - not establishedToxic - not established. Urine Reference Ranges: Normal - not establishedToxic - not established. /Organophosphate pesticides/Pulmonary Function Tests: The tests that have been found to be practical for population monitoring include: Spirometry and expiratory flow-volume curvesDetermination of lung volumesDiffusing capacity for carbon monoxideSingle-breath nitrogen washoutInhalation challenge testsSerial measurements of peak expiratory flowExercise testing. /Organophosphate pesticides/For more Medical Surveillance (Complete) data for AZINPHOS ETHYL (7 total), please visit the HSDB record page.
Soil Adsorption/MobilityUsing a structure estimation method based on molecular connectivity indices(1), the Koc of azinphos ethyl can be estimated to be 170(SRC). According to a classification scheme(2), this estimated Koc value suggests that azinphos ethyl is expected to have moderate mobility in soil. Using a lysimeter to measure the leachability of various pesticides, azinphos ethyl was not detected in leachate from 3,000 individual analyses conducted from 1977-1986 (detection limit 0.001 mg/L)(3). These tests were conducted using 1-1.3 m in height by 0.5 sq m of top soil with a catch base of 1 sq m(3). For soil material, loamy or silty sand with a low humus content was used where the sum of clay and silt amounted to a maximum of 30% (clay below 10%) and the content of organic bound carbon did not exceed 1.5%(3).
CERCLA 報告数量Releases of CERCLA hazardous substances are subject to the release reporting requirement of CERCLA section 103, codified at 40 CFR part 302, in addition to the requirements of 40 CFR part 355. Azinphos-ethyl is an extremely hazardous substance (EHS) subject to reporting requirements when stored in amounts in excess of its threshold planning quantity (TPQ) of 100 or 10,000 lbs. Extremely hazardous substances that are solids are subject to either of two threshold planning quantities ... The lower quantity applies only if the solid exists in powdered form and has a particle size less than 100 micronsor is handled in solution or in molten formor meets the criteria for a National Fire Protection Association (NFPA) rating of 2, 3 or 4 for reactivity. If the solid does not meet any of these criteria, it is subject to the upper ... threshold planning quantity ... .
水環境危害等級（WGK）3
RTECS 番号TD8400000
輸送番号（UN）2783
危険文句（R）24-28-50/53
危険表示T+,N
安全措置（S）28-36/37-45-60-61
危険等級6.1(a)Acute Tox. 2 OralAcute Tox. 3 DermalAquatic Acute 1Aquatic Chronic 1
包装等級II
貯蔵分類6.1A - Combustible, acute toxic Cat. 1 and 2very toxic hazardous materials
有害物質データ2642-71-9(Hazardous Substances Data)