AG1296
AG1296 · 6,7-ジメトキシ-2-フェニルキノキサリン · AG-1296 · チルホスチンAG-1296 · 2-フェニル-6,7-ジメトキシキノキサリン · 1296 · AG 1296 · A 1296
識別子と物理属性
| CAS No. | 146535-11-7 |
|---|---|
| 分子式 | C16H14N2O2 |
| 平均分子量 | 266.29 g/mol |
| 単同位体質量 | 266.10552769 g/mol |
| SMILES | COc1cc2ncc(-c3ccccc3)nc2cc1OC |
| InChIKey | QNOXYUNHIGOWNY-UHFFFAOYSA-N |
| PubChem CID | 2049 |
| ChEMBL | CHEMBL71191 |
| ChEBI | CHEBI:93335 |
| DTXSID | DTXSID70163393 |
| 現地名 | AG1296 |
化学・物理的性質
| XLogP | 2.8 |
|---|---|
| 極性表面積 | 44.2 |
| 水素結合供与体数 | 0 |
| 水素結合受容体数 | 4 |
| 回転可能結合数 | 3 |
| 重原子数 | 20 |
| 形式電荷 | 0 |
| 複雑度 | 307 |
| 沸点 | 420.2±40.0 °C(Predicted) |
| 密度 | 1.192±0.06 g/cm3(Predicted) |
| 貯蔵条件 | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
| 溶解度 | DMSOに可溶。 |
| pKa（酸解離定数） | 0.48±0.30(Predicted) |
| 外観・状態 | 白い固体 |
| 色 | 黄色 |
| 安定性 | -20°C の DMSO 溶液で最大 3 か月間保存できます。 |
| InChI | 1S/C16H14N2O2/c1-19-15-8-12-13(9-16(15)20-2)18-14(10-17-12)11-6-4-3-5-7-11/h3-10H,1-2H3 |
| InChIKey | QNOXYUNHIGOWNY-UHFFFAOYSA-N |
安全性と法規制
| 水環境危害等級（WGK） | 3 |
|---|---|
| 貯蔵分類 | 11 - Combustible Solids |
用途
説明
Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which act as PTK blockers. PTK inhibitors specific for platelet-derived growth factor (PDGF) receptor kinase could help in the treatment of atherosclerosis, restenosis, pulmonary fibrosis, and gliomas. AG-1296 is a potent and selective inhibitor of PDGF receptor kinase with an IC50 value of about 0.4 μM both in vitro and in cells (Swiss 3T3 cells). It inhibits ligand-stimulated DNA synthesis in platelet-derived growth factor receptor and stem cell factor/kit receptor transfected cells with an IC50 values of 1.5 and 1.8 μM, respectively. Treatment of sis oncogene transfected NIH3T3 cells with AG-1296 reverses the transformed phenotype.
使用
Tyrphostin AG 1296, is the platelet-derived growth factor receptor (PDGFR) inhibitor, which can causes growth inhibition in glioblastoma cells.