ペニシリンGカリウム

Penicillin G Potassium

HCID 23664709

基本情報

CAS
113-98-4
標準SMILES
CC1(C)S[C@@H]2[C@H](NC(=O)Cc3ccccc3)C(=O)N2[C@H]1C(=O)[O-].[K+]
InChIKey
IYNDLOXRXUOGIU-LQDWTQKMSA-M
分子式
C16H17KN2O4S
平均分子量
372.5 g/mol
単同位体質量
372.0546097

概要

Benzylpenicillin potassium is organic potassium salt of benzylpenicillin. It contains a benzylpenicillin(1-).

名称と識別子

優先名称
Penicillin G Potassium
IUPAC
potassium (2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
現地名
ペニシリンGカリウム
英語名
Penicillin G potassium salt
分子式
C16H17KN2O4S
分子量
373.49

名称と別名

Penicillin G potassium113-98-4Benzylpenicillin potassiumPenicillin G potassium saltPotassium benzylpenicillinPotassium penicillin GPentidsBenzylpenicillin potassium saltPenicillin G KPotassium benzylpenicillinatePfizerpenbenzylpenicilline potassique
名称をさらに表示
ペニシリンGカリウム(6R)-6α-(α-オキソフェネチルアミノ)ペニシラン酸カリウム結晶ペニシリンGカリウム(2S,5β)-6α-(ベンジルカルボニルアミノ)-7-オキソ-3,3-ジメチル-1-アザ-4-チアビシクロ[3.2.0]ヘプタン-2β-カルボン酸カリウムベンジルペニシリンカリウム(6R)-6-[(フェニルアセチル)アミノ]ペニシラン酸カリウム(2S,5β)-3,3-ジメチル-6α-(フェニルアセチルアミノ)-7-オキソ-4-チア-1-アザビシクロ[3.2.0]ヘプタン-2β-カルボン酸カリウム(2S,5R,6R)-6-(ベンジルカルボニルアミノ)-3,3-ジメチル-7-オキソ-4-チア-1-アザビシクロ[3.2.0]ヘプタン-2-カルボン酸カリウムペニシリンGカリウム標準品ペニシリンGカリウム塩ペニシリンGカリウム塩標準品ペニシリンG, カリウム塩ペニシリン酸ベンジルカリウム塩ベンジルペニシリンカリウム標準品ペニシリンG カリウム塩ベンジルペニシリンカリウム (JP17)Penicilline GPen-GPenicillin PotassiuMPenicillin G potassium First Crystalpotassium [2s-(2alpha,5alpha,6beta)]-3,3-dimethyl-7-oxo-6-(phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
SugracillinCapicillinLiquapenScotcilTabilinPotassium salt of benzylpenicillinPfizerpen GPENICILLIN-2

データベース識別子

CAS
113-98-4
PubChem CID
23664709
DTXSID
DTXSID7045106
ChEMBL
CHEMBL1223
ChEBI
CHEBI:7963
UNII
VL775ZTH4C
EC Number
204-038-0

物性

構造計算による物性

極性表面積
115 Ų
水素結合供与体数
1
水素結合受容体数
5
回転可能結合数
4
重原子数
24

実験および物理化学的性質

Human Drugs · 2 件

FDA approved drugs -> Active ingredient

FDA approved drugs -> Active ingredient

Animal DrugsActive Ingredients (Penicillin G Potassium) -> FDA Greenbook
Collision Cross Section174.5 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

物理化学的性質

融点
214 · 214-217 C
比旋光度
22 · D22 +285° (c = 0.748 in water)
屈折率
294 ° · 294 ° (C=1, H2O)
貯蔵温度
-20 °C · Sealed in dry,Store in freezer, under -20°C
溶解性
2 O: · H2O: 100 mg/mL
外見
粉
化学的性質 · 1 件

化学的特性Penicillin G potassium salt is also known as Potassium benzylpenicillin, it is white crystalline powder, odorless or slightly specific odor, hygroscopic. Soluble in water, physiological saline, glucose solution. The aqueous solution of it is easy to fail when placed at room temperature, and it will fail rapidly in the presence of acid, alkali, oxidant, etc. Penicillin G potassium salt has good antibacterial effect on Streptococcus such as Streptococcus hemolyticus, Streptococcus pneumoniae and Staphylococcus without penicillinase.

安全と法規制

GHS分類

GHS Classification · 4 件

Danger

H315 (16.2%): Causes skin irritation [Warning Skin corrosion/irritation]

P233, P260, P261, P264, P264+P265, P271, P272, P280, P284, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P333+P317, P337+P317, P342+P316, P362+P364, P403, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 80 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

危険有害性情報

Regulatory Information · 2 件

Status: Active Update: 30-05-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/22421

Penicillin g potassium: Does not have an individual approval but may be used under an appropriate group standard

Other Safety InformationIMAP assessments - 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]- [2S-(2.alpha.,5.alpha.,6.beta.)]-, monopotassium salt: Environment tier I assessment
Hazard Classes and CategoriesSkin Irrit. 2 (16.2%)

安全データ

F
10-23
wgk
2
tsca
TSCA listed
rtecs
XH9700000
毒性
LD50 oral in rabbit: 5848mg/kg
hs_code
29411000

化学と産業

薬理情報

FDA Pharmacological Classification · 4 件

BUFFERED PENICILLIN G POTASSIUM

Penicillin-class Antibacterial [EPC]; Penicillins [CS]

PENICILLIN G POTASSIUM

Penicillins [CS]; Penicillin-class Antibacterial [EPC]

MeSH Pharmacological ClassificationSubstances that inhibit the growth or reproduction of BACTERIA.

用途と製造

Use ClassificationAnimal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients
General Manufacturing Information4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]- (2S,5R,6R)-, potassium salt (1:1): ACTIVE
応用分野 · 6 件

用途組織培養液添加用、遺伝子工学、耐性菌の研究。

用途動物用医薬品標準品。

用途ペニシリン系抗生物質です。 ペニシリン結合タンパクに結合し、細胞壁の 合成阻害を示します。

用途ペニシリン系抗生物質です。 ペニシリン結合タンパク質に結合し、細胞壁 の合成阻害作用を示します。抗菌スペクトル は狭いが、グラム陰性菌・グラム陽性菌に対 して抗菌力を示します。

使用Penicillin G is a narrow spectrum antibiotic derived from Streptococcus pneumoniae. Penicillin G potassium salt is used as a cell culture additive as an antibiotics. Use to inhibit the synthesis of bacterial cell walls by inhibition of the cell wall peptidoglycan chain cross-lining. It is the drug of choice for groups A, B, C and G streptococci, nonenterococcal group D streptococci, viridians group streptococci, and non-penicillinase producing staphylococcus. The potassium salt has been used to study murosomes of staphylococci and the penicillin-induced lysis of Streptococcus mutans.

一般的な説明Penicillin G Potassium is the potassium salt form of penicillin G, a broad-spectrum penicillin antibiotic. Penicillin G potassium binds to penicillin binding proteins (PBP), the enzymes that catalyze the synthesis of peptidoglycan, which is a critical component of the bacterial cell wall. This leads to the interruption of cell wall synthesis, consequently leading to bacterial cell growth inhibition and cell lysis.

調製方法

製造方法Penicillin G potassium salt is a highly effective and low toxicity antibiotic, which is obtained by salt formation of Chlorpheniramine maleate and maleic acid.

サプライヤー100 社

国药集团化学试剂有限公司86-21-63210123 · [email protected]
北京华美互利生物化工010-56205725 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
清宁生物(江苏博泉生物科技有限公司)19352250998 · [email protected]

補足説明

定義ChEBI: Penicillin G potassium salt is organic potassium salt of benzylpenicillin. It is an antibiotic substance produced by Penicillium sp. Antibacterial. It contains a benzylpenicillin(1-).

関連反応

57 件

化合物ノート

読み込み中…