基本情報
- CAS
113-98-4- 標準SMILES
CC1(C)S[C@@H]2[C@H](NC(=O)Cc3ccccc3)C(=O)N2[C@H]1C(=O)[O-].[K+]- InChIKey
IYNDLOXRXUOGIU-LQDWTQKMSA-M- 分子式
- C16H17KN2O4S
- 平均分子量
- 372.5 g/mol
- 単同位体質量
- 372.0546097
概要
Benzylpenicillin potassium is organic potassium salt of benzylpenicillin. It contains a benzylpenicillin(1-).
名称と識別子
- 優先名称
- Penicillin G Potassium
- IUPAC
- potassium (2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
- 現地名
- ペニシリンGカリウム
- 英語名
- Penicillin G potassium salt
- 分子式
- C16H17KN2O4S
- 分子量
- 373.49
名称と別名
名称をさらに表示
データベース識別子
- CAS
113-98-4- PubChem CID
- 23664709
- DTXSID
DTXSID7045106- ChEMBL
CHEMBL1223- ChEBI
CHEBI:7963- UNII
- VL775ZTH4C
- EC Number
- 204-038-0
物性
構造計算による物性
- 極性表面積
- 115 Ų
- 水素結合供与体数
- 1
- 水素結合受容体数
- 5
- 回転可能結合数
- 4
- 重原子数
- 24
- 形式電荷
- 0
- 複雑度
- 536
実験および物理化学的性質
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
物理化学的性質
- 融点
- 214 · 214-217 C
- 比旋光度
- 22 · D22 +285° (c = 0.748 in water)
- 屈折率
- 294 ° · 294 ° (C=1, H2O)
- 貯蔵温度
- -20 °C · Sealed in dry,Store in freezer, under -20°C
- 溶解性
- 2 O: · H2O: 100 mg/mL
- 外見
- 粉
- 色
- ブタノール(aq)からの針
- PH
- pH (10g/L, 25℃) : 5.0~7.5
- 水溶解度
- 100 mg/ml)、メタノール、エタノール · 水(100mg/ml)、メタノール、エタノール(少量)、アルコールに可溶。クロロホルムに不溶。
- Merck
- 14 · 14,7094
- BRN
- 3832841 · 3832841
- 安定性
- 吸湿性
- InChIKey
- IYNDLOXRXUOGIU-LQDWTQKMSA-M
- SMILES
- N12C([C@@H](NC(=O)CC3=CC=CC=C3)[C@@]1([H])SC(C)(C)[C@@H]2C([O-])=O)=O.[K+] |&1:2,13,19,r|
- EPAの化学物質情報
- Penicillin G Potassium (113-98-4)
化学的性質
化学的特性Penicillin G potassium salt is also known as Potassium benzylpenicillin, it is white crystalline powder, odorless or slightly specific odor, hygroscopic. Soluble in water, physiological saline, glucose solution. The aqueous solution of it is easy to fail when placed at room temperature, and it will fail rapidly in the presence of acid, alkali, oxidant, etc. Penicillin G potassium salt has good antibacterial effect on Streptococcus such as Streptococcus hemolyticus, Streptococcus pneumoniae and Staphylococcus without penicillinase.
安全と法規制
GHS分類
GHS Classification
Danger
H315 (16.2%): Causes skin irritation [Warning Skin corrosion/irritation]
P233, P260, P261, P264, P264+P265, P271, P272, P280, P284, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P333+P317, P337+P317, P342+P316, P362+P364, P403, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 80 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
危険有害性情報
Regulatory Information
Status: Active Update: 30-05-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/22421
Penicillin g potassium: Does not have an individual approval but may be used under an appropriate group standard
安全データ
- F
- 10-23
- wgk
- 2
- tsca
- TSCA listed
- rtecs
- XH9700000
- 毒性
- LD50 oral in rabbit: 5848mg/kg
- hs_code
- 29411000
- risk_code
- 42/43-34-11
- hazard_code
- Xn,C,F
- safety_code
- 36/37-45-36/37/39-26-16-60-37-24-22
- Hazard Classifications
- Skin Sens. 1
- ストレージクラス
- 11 - Combustible Solids
化学と産業
薬理情報
FDA Pharmacological Classification
BUFFERED PENICILLIN G POTASSIUM
Penicillin-class Antibacterial [EPC]; Penicillins [CS]
PENICILLIN G POTASSIUM
Penicillins [CS]; Penicillin-class Antibacterial [EPC]
用途と製造
応用分野
用途組織培養液添加用、遺伝子工学、耐性菌の研究。
用途動物用医薬品標準品。
用途ペニシリン系抗生物質です。 ペニシリン結合タンパクに結合し、細胞壁の 合成阻害を示します。
用途ペニシリン系抗生物質です。 ペニシリン結合タンパク質に結合し、細胞壁 の合成阻害作用を示します。抗菌スペクトル は狭いが、グラム陰性菌・グラム陽性菌に対 して抗菌力を示します。
使用Penicillin G is a narrow spectrum antibiotic derived from Streptococcus pneumoniae. Penicillin G potassium salt is used as a cell culture additive as an antibiotics. Use to inhibit the synthesis of bacterial cell walls by inhibition of the cell wall peptidoglycan chain cross-lining. It is the drug of choice for groups A, B, C and G streptococci, nonenterococcal group D streptococci, viridians group streptococci, and non-penicillinase producing staphylococcus. The potassium salt has been used to study murosomes of staphylococci and the penicillin-induced lysis of Streptococcus mutans.
一般的な説明Penicillin G Potassium is the potassium salt form of penicillin G, a broad-spectrum penicillin antibiotic. Penicillin G potassium binds to penicillin binding proteins (PBP), the enzymes that catalyze the synthesis of peptidoglycan, which is a critical component of the bacterial cell wall. This leads to the interruption of cell wall synthesis, consequently leading to bacterial cell growth inhibition and cell lysis.
調製方法
製造方法Penicillin G potassium salt is a highly effective and low toxicity antibiotic, which is obtained by salt formation of Chlorpheniramine maleate and maleic acid.
上流・下流製品情報
上流原料
下流製品
サプライヤー100 社
補足説明
定義ChEBI: Penicillin G potassium salt is organic potassium salt of benzylpenicillin. It is an antibiotic substance produced by Penicillium sp. Antibacterial. It contains a benzylpenicillin(1-).
関連反応
化合物ノート
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