6-Nitro-3-phenylacetamidobenzoic acid → 6-Aminopenicillanic acid

HRID 267182

反応式

HRID 267182 の反応式
C1C=CC(CC(NC2C=CC([N+]([O-])=O)=C(C(O)=O)C=2)=O)=CC=1.[CH3:23][C:24]1([CH3:45])[S:28][C@@H:27]2[C@H:29]([NH:32]C(CC3C=CC=CC=3)=O)[C:30](=[O:31])[N:26]2[C@H:25]1[C:42]([O-:44])=[O:43].[K+]>O>[CH3:23][C:24]1([CH3:45])[S:28][C@@H:27]2[C@H:29]([NH2:32])[C:30](=[O:31])[N:26]2[C@H:25]1[C:42]([OH:44])=[O:43]

参加物

4

反応物 2

HCID 1938646-Nitro-3-phenylacetamidobenzoic acidHCID 23664709Penicillin G Potassium

生成物 1

HCID 110826-Aminopenicillanic acid

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
38 °C

実験手順

330 g of carrier-bound penicillinacylase produced according to Example 1, having an enzymatic activity of 3,410 U (NIPAB test) and 129 g of potassium penicillin G are successively added to 2,000 ml of water and stirred at 38°C. and pH 7.8 as described in Example 14. The penicillin G is completely split to 6-APA and phenylacetic acid over the course of 2 hours. The 6-APA is isolated as described in Example 14. The carrierbound penicillinacylase is employed 20 times in succession. Even after the twentieth splitting, the reaction time does not have to be extended to achieve complete splitting.

後処理

  1. custom330 g of carrier-bound penicillinacylase produced
  2. customThe penicillin G is completely split to 6-APA and phenylacetic acid over the course of 2 hours

出典と根拠

ORDレコード
ord-4b6ddb4097a74bda95fdc984c65e90cf
出典データセット
uspto-grants-1976_03
特許番号
US03941756

関連ノート

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