Calcium Sulfate Dihydrate

Mineral Dusts -> Other Mineral Dusts

Metals -> Metals, Inorganic Compounds

2.32 (NIOSH, 2024) - Denser than water; will sink

2.32 g/cm³

2.32

2.32

0.2 % at 77 °F (NIOSH, 2024)

Solubility in water, g/100ml at 20 °C: 0.2 (very poor)

(77 °F): 0.2%

262 to 325 °F (Loses H2O) (NIOSH, 2024)

100-150 °C

262-325 °F (loses H₂O)

262-325 °F (Loses H2O)

0 mmHg (approx) (NIOSH, 2024)

0 mmHg (approx)

0 mmHg (approx)

Gypsum appears as white or nearly white, odorless, crystalline solid.

Dry Powder

Dry Powder; Other Solid; CBI

White or nearly white, odorless, crystalline solid;

White to slightly yellowish-white odorless solid; [Merck Index] Colorless hygroscopic solid; [OECD SIDS: Calcium sulfate, dihydrate - 2003] White powder; [Sigma-Aldrich MSDS]

CRYSTALLINE POWDER.

This chemical does not meet GHS hazard criteria for 100% (278 of 278) of all reports.

Not Classified

Aggregated GHS information provided per 278 reports by companies from 2 notifications to the ECHA C&L Inventory.

This chemical does not meet GHS hazard criteria for 100% (40 of 40) of all reports.

Not Classified

Aggregated GHS information provided per 40 reports by companies from 1 notifications to the ECHA C&L Inventory.

Chemical: Sulfuric acid, calcium salt, dihydrate

Directive (EC) No 46/2002

Gypsum (Ca(SO4).2H2O) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Gypsum (Ca(SO4).2H2O) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Sulfuric acid, calcium salt (1:1), dihydrate is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Sulfuric acid, calcium salt (1:1), dihydrate are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Calcium sulfate dihydrate: Does not have an individual approval but may be used under an appropriate group standard

Gypsum (Ca(SO4).2H2O): Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

A cross-sectional study of 241 British gypsum miners in Sussex and Nottinghamshire with over 20 years of exposure identified x-ray findings consistent with a simple pneumoconiosis. Sixty-four miners had >1/0 on the ILO scale and 3 miners had 2/1 or greater. The authors attributed the higher rates of slight pneumoconiosis in the Sussex miners to the higher levels of quartz in these mines where the levels of gypsum dust were lower. [ACGIH] See Calcium sulfate.

Not a skin irritant in rabbits; No evidence of skin sensitization in guinea pigs; Decreased total protein, albumin, BUN, AST, ALT, and creatinine observed in males at 300 and 1,000 mg/kg/day in repeated-dose oral study of rats (possible effect on excretion, distribution, or metabolism relating to the kidney); No adverse effects observed in females at dose up to 1,000 mg/kg/day; No evidence of reproductive or developmental toxicity in rats at oral doses up to 1,000 mg/kg/day; No evidence of mutagenicity; [OECD SIDS: Calcium sulfate, dihydrate - 2003] May cause mechanical irritation; Repeated or prolonged exposure to dust particles may cause lung effects; [ICSC] May cause irritation; [Sigma-Aldrich MSDS] See Calcium sulfate. See Gypsum.

Not Classified

Not Classified

Specific target organ toxicity - Single exposure - Category 3 (Respiratory tract irritation)

Specific target organ toxicity - Single exposure - Category 3 (Respiratory tract irritation)

Fresh air, rest.

Rinse and then wash skin with water and soap.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth.

Excerpt from NIOSH Pocket Guide for Gypsum:

(General first aid procedures)

4.0 [mg/m3], (inhalable fraction), 1.5 mg/m3 (respirable fraction)[German Research Foundation (DFG)]

4.0 [mg/m3](inhalable fraction), 1.5 mg/m3(respirable fraction)[German Research Foundation (DFG)]

10.0 [mg/m3], inhalable fraction

10.0 [mg/m3], inhalable fraction

(inhalable fraction): 10 mg/m

10 mg/m³ (inhalable particulate matter) [2005]

Cough.

Redness.

irritation eyes, skin, mucous membrane, upper respiratory system; cough, sneezing, rhinorrhea (discharge of thin nasal mucus)

Used to manufacture plasterboard and plaster of Paris; [Harber, p. 358]

Mining [Category: Industry]

Used to make Portland cement, plaster of Paris, artificial marble, and porous polymers; Also used in soil treatment, paints/enamels (pigment), pharmaceuticals, paper, insecticide dusts, water treatment, polishing powders, and plaster casts; [Merck Index] Used in Portland cement retarders, tiles, plaster, wallboard, polishing powders, paints, paper, dyeing and calico printing, metallurgy (reduction of zinc minerals), food additives, desiccants, as source of sulfur and sulfuric acid, for drying industrial gases, solids, and organic liquids, as soil conditioner, in adhesives and binding agents, and to make other non-metallic mineral products; [OECD SIDS: Calcium sulfate, dihydrate - 2003] Permitted for use as an inert ingredient in non-food pesticide products; [EPA]

Pulp and Paper Processing [Category: Industry]

2023: 2,090,000,000 lb

2023: 1,000,000 - <5,000,000 lb

Filler

Not Known or Reasonably Ascertainable

Filler

Soil amendments (fertilizers)

Information on 100 consumer products that contain Calcium sulfate dihydrate in the following categories is provided:

Information on 112 consumer products that contain Gypsum in the following categories is provided:

Agriculture, Forestry, Fishing and Hunting

Agriculture, Forestry, Fishing and Hunting