3,4,5,6-Tetrafluorophthalic acid → 2,3,4,5-Tetrafluorobenzoic acid

HRID 622249

反応式

HRID 622249 の反応式
[F:1][C:2]1[C:10]([F:11])=[C:9]([F:12])[C:8]([F:13])=[C:4](C(O)=O)[C:3]=1[C:14]([OH:16])=[O:15]>O.O.O.S([O-])([O-])(=O)=O.[Ca+2]>[F:1][C:2]1[C:10]([F:11])=[C:9]([F:12])[C:8]([F:13])=[CH:4][C:3]=1[C:14]([OH:16])=[O:15]

参加物

4

反応物 1

HCID 695443,4,5,6-Tetrafluorophthalic acid

生成物 1

HCID 2975492,3,4,5-Tetrafluorobenzoic acid

試薬・触媒・溶媒 2

HCID 24928Calcium Sulfate Dihydrate触媒HCID 962Water溶媒

実験手順

Decarboxylation of 150 g of 3,4,5,6-tetrafluorophthalic acid in 500 g of water was effected by following the procedure of Example 1, except that 54.2 g (0.315 mole) of calcium sulfate dihydrate was used as a catalyst and the heating and stirring were carried out at 170° C. for 14 hous [pH 1.37 at 70° C. at the time of charging]. After completion of the reaction, the reaction product was separated by following the procedure, to produce 2,3,4,5-tetrafluorobenzoic acid in a yield of 86.4 mole % as found by the same calculation.

後処理

  1. customwere carried out at 170° C. for 14
  2. customat 70° C.
  3. customAfter completion of the reaction
  4. customthe reaction product was separated

出典と根拠

ORDレコード
ord-565d3c0a5b5543e2ada66dd1a86c4635
出典データセット
uspto-grants-1988_09
特許番号
US04769492

関連ノート

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