プロピオン酸 ナトリウム

Fresh air, rest.

Rinse skin with plenty of water or shower.

Rinse with plenty of water (remove contact lenses if easily possible).

Rinse mouth. Give one or two glasses of water to drink.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Wash away remainder with plenty of water.

Sodium propionate is exempted from the requirement of a tolerance for residues when used as follows: (a) as a fungicide in the production of garlic; and (b) for postharvest application as a preservative on salad greens and vegetables intended for consumption as salads.

Residues of sodium propionate are exempted from the requirement of a tolerance when used as a preservative for formulation in accordance with good agricultural practices as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops or to raw agricultural commodities after harvest.

IN RATS, VITAMIN B12 PREVENTED GROWTH LOSS CAUSED BY SODIUM PROPIONATE.

SODIUM PROPIONATE EXERTED SIGNIFICANT PROTECTIVE EFFECT AGAINST AMMONIA INTOXICATION IN CHICKS WHEN ADMIN IP 7 HR PRIOR TO AMMONIUM ACETATE CHALLENGE. EFFECTIVE DOSES RANGED FROM 3-4 MMOLE/KG.

Cough. Sore throat.

Redness. Pain.

IN RAT FEEDING TRIALS ... SODIUM ... PROPIONATE HAD NO EFFECT ON GROWTH WHEN FED @ LEVELS OF 1-3 G DAILY, FOR 4-5 WK, BEGINNING WHEN ANIMALS WERE ABOUT 4 WK OF AGE. IN LATER STUDIES ... 5% PROPIONATE ... IN BREAD BEFORE BAKING ... WAS FED AS 3/4 OF DIET ... FOR 1 YR. THERE WAS NO DISCERNIBLE TOXICITY ...

... /AFTER/ PROLONGED FEEDING ... TO RATS AT 50 TIMES THE LEVEL USED IN BREAD ... TEMPORARY GROWTH DEPRESSION WAS THE ONLY EFFECT SEEN.

The effects of short-chain fatty acids (SCFA) on the contractile response of rat ileum were studied in vivo. The contractile response was estimated by means of changes in the intraluminal pressure under the isometric condition. IV admin of the sodium salt produced biphasic contractions: an initial phasic contraction and subsequent tonic contraction. Sigmoid dose-response curve was obtained for the phasic contraction. Repeated admin of propionate at intervals of less than 3 min led to tachyphylaxis, and this tachyphylaxis disappeared by about 10 min. Short-chain fatty acids induced the biphasic contraction of the rat ileum, probably by neurogenic and myogenic mechanisms.

Propionate (2.5 mmol/kg as the sodium salt) was infused rapidly via a jugular vein into each of 13 multiparous Holstein cows at 7 wk postpartum for observation of clearance of propionate. Associated concn changes of acetic acid and glucose in blood plasma and glucagon & insulin in blood serum were quantified. This dose elevated concn of propionate, which declined subsequently at an exponential rate. Concn of glucagon & insulin were incr in the sampling immediately following infusion, yet subsequent decline of insulin concn acted to decr the molar ratio of insulin:glucagon as propionate returned to preinfusion concn. There was a negative correlation between glucose and molar ratio of insulin:glucagon. A supraphysiological dose of propionate has an immediate effect on the pancreas to alter endocrine secretion in the lactating cow.

LD50 Mouse oral 6332 mg/kg

LD50 Mouse sc 2100 mg/kg

LD50 Rabbit skin 1640 mg/kg

Substances classified as antimycotics, when migrating from food-packaging material include sodium propionate.

Substance added directly to human food affirmed as generally recognized as safe (GRAS) when meeting specified requirements.

Sodium propionate used as a chemical preservative in animal drugs, feeds, and related products is generally recognized as safe when used in accordance with good manufacturing or feeding practice.

Sodium propionate is exempted from the requirement of a tolerance for residues when used as follows: (a) as a fungicide in the production of garlic; and (b) for postharvest application as a preservative on salad greens and vegetables intended for consumption as salads.

Residues of sodium propionate are exempted from the requirement of a tolerance when used as a preservative for formulation in accordance with good agricultural practices as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops or to raw agricultural commodities after harvest.

As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their future use. Under this pesticide reregistration program, EPA examines health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether they are eligible for reregistration. In addition, all pesticides must meet the new safety standard of the Food Quality Protection Act of 1996. Pesticides for which EPA had not issued Registration Standards prior to the effective date of FIFRA, as amended in 1988, were divided into three lists based upon their potential for human exposure and other factors, with List B containing pesticides of greater concern and List D pesticides of less concern. Sodium propionate is found on List D. Case No: 4078; Case Status: RED Approved 09/91; OPP has made a decision that some/all uses of the pesticide are eligible for reregistration, as reflected in a Reregistration Eligibility Decision (RED) document.; Active ingredient (AI): Sodium propionate; AI Status: The active ingredient is no longer contained in any registered pesticide products ... "cancelled."