4-(2-ヒドロキシエチル)-1-ピペラジンエタン-1-スルホン酸ナトリウム

Sodium 2-(4-(2-hydroxyethyl)piperazin-1-yl)ethanesulfonate

HCID 2724248

基本情報

CAS
75277-39-3
標準SMILES
O=S(=O)([O-])CCN1CCN(CCO)CC1.[Na+]
InChIKey
RDZTWEVXRGYCFV-UHFFFAOYSA-M
分子式
C8H17N2NaO4S
平均分子量
260.29 g/mol
単同位体質量
260.08067248

名称と識別子

優先名称
Sodium 2-(4-(2-hydroxyethyl)piperazin-1-yl)ethanesulfonate
IUPAC
sodium 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonate
現地名
4-(2-ヒドロキシエチル)-1-ピペラジンエタン-1-スルホン酸ナトリウム
英語名
HEPES sodium salt
分子式
C8H19N2NaO4S
分子量
261.3

名称と別名

75277-39-3Sodium 2-(4-(2-hydroxyethyl)piperazin-1-yl)ethanesulfonate103404-87-1sodium 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonateHEPES (sodium)4-(2-Hydroxyethyl)piperazine-1-ethanesulfonic acid hemisodium saltZ9FTO91O8A1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-, monosodium saltUNII-Z9FTO91O8AC8H17N2NaO4SMFCD00036463hepes sodium
名称をさらに表示
4-(2-ヒドロキシエチル)-1-ピペラジンエタン-1-スルホン酸ナトリウム4-(2-ヒドロキシエチル)-1-ピペラジンエタンスルホン酸ナトリウム2-〔4-(2-ヒドロキシエチル)-1-ピペラジニル〕エタンスルホン酸ナトリウム2-〔4-(2-ヒドロキシエチル)-1-ピペラジン〕エタンスルホン酸ナトリウムHEPESナトリウム塩HEPES, ナトリウム塩, 細胞培養用, ~99%HEPES ナトリウム塩HEPES ナトリウム塩 溶液HEPES ナトリウム塩 水和物2-[4-(2-ヒドロキシエチル)ピペラジノ]エタンスルホン酸ナトリウムナトリウム 2-[4-(2-ヒドロキシエチル)ピペラジン-1-イル]エタン-1-スルホナート2-[4-(2-ヒドロキシエチル)-1-ピペラジン]エタンスルホン酸ナトリウムHEPES NAHEPES SODIUM SALT BUFFERHEPES, SODIUMH7006-500G(HEPES)2-NAHEPES NA-SALTRUTHENIUM STANDHEPES LOWSODIUMHEPES SODIUM SALT1.0 M HEPES sodium
4-(2-Hydroxyethyl)piperazine-1-ethanesulfonic acid sodium saltDTXSID4044458Sodium 4-(2-hydroxyethyl)piperazin-1-ylethanesulphonatesodium;2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonateEINECS 278-169-71-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-, sodium salt (1:1)AKOS015897769FT-0610868

データベース識別子

CAS
75277-39-3
PubChem CID
2724248
DTXSID
DTXSID4044458
ChEMBL
CHEMBL3187284
ChEBI
CHEBI:46758
UNII
Z9FTO91O8A
EC Number
278-169-7
Nikkaji
J307.551F

物性

構造計算による物性

極性表面積
92.3 Ų
水素結合供与体数
1
水素結合受容体数
6
回転可能結合数
5
重原子数
16

実験および物理化学的性質

Physical Description · 2 件

Dry Powder

White powder; [Sigma-Aldrich MSDS]

物理化学的性質

融点
234 °C · 234 °C
比重(密度)
1.504 · 1.504[at 20℃]
蒸気圧
0 Pa · 0Pa at 25℃
貯蔵温度
room temp
溶解性
2 O: · H2O: 1M at20℃、透明、無色
外見
乾燥粉末

化学的性質

化学的特性white powder

安全と法規制

GHS分類

GHS Classification · 3 件

This chemical does not meet GHS hazard criteria for 98.8% (160 of 162) of all reports.

Not Classified;Reported as not meeting GHS hazard criteria by 160 of 162 companies (only 1.2% companies provided GHS information). For more detailed information, please visit ECHA C&L website.

Aggregated GHS information provided per 162 reports by companies from 3 notifications to the ECHA C&L Inventory.;Reported as not meeting GHS hazard criteria per 160 of 162 reports by companies.;There is 1 notification provided by 2 of 162 reports by companies with hazard statement code(s).;Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

危険有害性情報

Regulatory Information · 5 件

Chemical: 1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-, monosodium salt

1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-, sodium salt (1:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-, sodium salt (1:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

PMN - indicates a commenced PMN (Pre-Manufacture Notices) substance.

Status: Active Update: 08-02-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/21261

1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-, monosodium salt: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

Hazards SummaryMay cause irritation; [Sigma-Aldrich MSDS] See Piperazine and salts. See HEPES.
Hazard Classes and CategoriesNot Classified

法規制情報

Regulatory Information · 5 件

Chemical: 1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-, monosodium salt

1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-, sodium salt (1:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-, sodium salt (1:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

PMN - indicates a commenced PMN (Pre-Manufacture Notices) substance.

Status: Active Update: 08-02-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/21261

1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-, monosodium salt: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

安全データ

F
3-10
wgk
3
tsca
TSCA listed
hs_code
29335995
safety_code
22-24/25
ストレージクラス
13 - Non Combustible Solids

化学と産業

用途と製造

UsesA dipolar ionic buffer. [ChemIDplus]
U.S. Production2023: 28,556 lb
Consumer UsesStabilizing agent
Industry UsesStabilizing agent
General Manufacturing Information · 2 件

Pharmaceutical and Medicine Manufacturing

1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-, sodium salt (1:1): ACTIVE

応用分野 · 2 件

使用HEPES sodium salt solution is suitable for cell culture studies. It may be used in the preparation of buffer solution of HEPES. It may be used as buffer during the phosphorylation assays in permeabilized fibroblasts. It may be used to compose a complex dialysis buffer, used in the determination of free thyroxin in serum by radioimmunoassay.

一般的な説明HEPES is a general-purpose zwitterionic buffer which does not bind magnesium, calcium, manganese(II) or copper(II) ions. HEPES has been classified as Good′s buffer by Dr. Norman Good and his colleagues in 1966. It is zwitterionic at biological pH and is most effective in the pH range of 6.8 to 8.2.

サプライヤー100 社

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1 件

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