基本情報
- CAS
75277-39-3- 標準SMILES
O=S(=O)([O-])CCN1CCN(CCO)CC1.[Na+]- InChIKey
RDZTWEVXRGYCFV-UHFFFAOYSA-M- 分子式
- C8H17N2NaO4S
- 平均分子量
- 260.29 g/mol
- 単同位体質量
- 260.08067248
名称と識別子
- 優先名称
- Sodium 2-(4-(2-hydroxyethyl)piperazin-1-yl)ethanesulfonate
- IUPAC
- sodium 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonate
- 現地名
- 4-(2-ヒドロキシエチル)-1-ピペラジンエタン-1-スルホン酸ナトリウム
- 英語名
- HEPES sodium salt
- 分子式
- C8H19N2NaO4S
- 分子量
- 261.3
名称と別名
名称をさらに表示
データベース識別子
- CAS
75277-39-3- PubChem CID
- 2724248
- DTXSID
DTXSID4044458- ChEMBL
CHEMBL3187284- ChEBI
CHEBI:46758- UNII
- Z9FTO91O8A
- EC Number
- 278-169-7
- Nikkaji
- J307.551F
物性
構造計算による物性
- 極性表面積
- 92.3 Ų
- 水素結合供与体数
- 1
- 水素結合受容体数
- 6
- 回転可能結合数
- 5
- 重原子数
- 16
- 形式電荷
- 0
- 複雑度
- 272
実験および物理化学的性質
Physical Description
Dry Powder
White powder; [Sigma-Aldrich MSDS]
物理化学的性質
- 融点
- 234 °C · 234 °C
- 比重(密度)
- 1.504 · 1.504[at 20℃]
- 蒸気圧
- 0 Pa · 0Pa at 25℃
- 貯蔵温度
- room temp
- 溶解性
- 2 O: · H2O: 1M at20℃、透明、無色
- 外見
- 乾燥粉末
- 色
- 白い
- PH
- 10 · 10.0-12.0 (1M in H2O)
- 酸解離定数(Pka)
- 7.5 · 7.5(at 25℃)
- 由来生物
- synthetic
- 水溶解度
- 水に溶けます。
- 安定性
- 安定。吸湿性 - 湿気から保護します。強力な酸化剤とは相容れない。
- InChI
- 1S/C8H18N2O4S.Na.H2O/c11-7-5-9-1-3-10(4-2-9)6-8-15(12,13)14;;/h11H,1-8H2,(H,12,13,14);;1H2/q;+1;/p-1
- InChIKey
- ZNJHFNUEQDVFCJ-UHFFFAOYSA-M
- SMILES
- O.[Na+].OCCN1CCN(CC1)CCS([O-])(=O)=O
- CAS データベース
- 75277 · 75277-39-3(CAS DataBase Reference)
- EPAの化学物質情報
- 1 · 1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-, monosodium salt (75277-39-3)
- Absorption
- 0.2 at · ≤0.2 at 260 in H2O at 1M≤0.2 at 280 in H2O at 1M
化学的性質
化学的特性white powder
安全と法規制
GHS分類
GHS Classification
This chemical does not meet GHS hazard criteria for 98.8% (160 of 162) of all reports.
Not Classified;Reported as not meeting GHS hazard criteria by 160 of 162 companies (only 1.2% companies provided GHS information). For more detailed information, please visit ECHA C&L website.
Aggregated GHS information provided per 162 reports by companies from 3 notifications to the ECHA C&L Inventory.;Reported as not meeting GHS hazard criteria per 160 of 162 reports by companies.;There is 1 notification provided by 2 of 162 reports by companies with hazard statement code(s).;Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.
危険有害性情報
Regulatory Information
Chemical: 1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-, monosodium salt
1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-, sodium salt (1:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-, sodium salt (1:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
PMN - indicates a commenced PMN (Pre-Manufacture Notices) substance.
Status: Active Update: 08-02-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/21261
1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-, monosodium salt: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
法規制情報
Regulatory Information
Chemical: 1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-, monosodium salt
1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-, sodium salt (1:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-, sodium salt (1:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
PMN - indicates a commenced PMN (Pre-Manufacture Notices) substance.
Status: Active Update: 08-02-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/21261
1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-, monosodium salt: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
安全データ
- F
- 3-10
- wgk
- 3
- tsca
- TSCA listed
- hs_code
- 29335995
- safety_code
- 22-24/25
- ストレージクラス
- 13 - Non Combustible Solids
化学と産業
用途と製造
General Manufacturing Information
Pharmaceutical and Medicine Manufacturing
1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-, sodium salt (1:1): ACTIVE
応用分野
使用HEPES sodium salt solution is suitable for cell culture studies. It may be used in the preparation of buffer solution of HEPES. It may be used as buffer during the phosphorylation assays in permeabilized fibroblasts. It may be used to compose a complex dialysis buffer, used in the determination of free thyroxin in serum by radioimmunoassay.
一般的な説明HEPES is a general-purpose zwitterionic buffer which does not bind magnesium, calcium, manganese(II) or copper(II) ions. HEPES has been classified as Good′s buffer by Dr. Norman Good and his colleagues in 1966. It is zwitterionic at biological pH and is most effective in the pH range of 6.8 to 8.2.
上流・下流製品情報
上流原料
サプライヤー100 社
関連反応
化合物ノート
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