Piperazine → Sodium 2-(4-(2-hydroxyethyl)piperazin-1-yl)ethanesulfonate

HRID 1284413

反応式

HRID 1284413 の反応式
S([CH2:5][CH2:6][OH:7])([O-])(=O)=O.[Na+:8].N1CCNCC1.S(CCO)(O)(=O)=O.[N:22]1([CH2:28][CH2:29][S:30]([O-:33])(=[O:32])=[O:31])[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1.[Na+].C1OC1>O>[OH:7][CH2:6][CH2:5][N:25]1[CH2:26][CH2:27][N:22]([CH2:28][CH2:29][S:30]([O-:33])(=[O:31])=[O:32])[CH2:23][CH2:24]1.[Na+:8]

参加物

7

反応物 5

HCID 4837PiperazineHCID 6354Ethylene OxideHCID 7866Isethionic AcidHCID 517063Sodium IsethionateHCID 23377615sodium N-piperazineethanesulfonate

生成物 1

HCID 2724248Sodium 2-(4-(2-hydroxyethyl)piperazin-1-yl)ethanesulfonate

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
200 fahrenheit

実験手順

Forty-four grams of ethylene oxide (1 mole) is bled into a reaction vessel containing 104 grams of sodium bisulfite in water (45 percent by weight). The mixture is agitated at ambient temperature and 100 psi pressure during the addition of the bisulfite. The reactants interact to form an aqueous isethionic acid salt comprising 54 percent by weight sodium isethionate. A quantity of 86 grams of piperazine (1 mole) is admixed with the solution and the admixture is heated to a temperature of about 200° F. at atmospheric pressure. The reaction vessel has a cold finger trap attached thereto in communication with the contents of the reaction vessel. As the reaction progresses, water is produced as a by-product of the reaction which vaporizes as it is formed together with the other water present and which is collected as ice crystals upon the cold finger trap. The heating is continued for approximately 4 hours after which approximately 38 percent by weight of the reactants (about 127 grams) in the reaction vessel have collected upon the cold finger trap as ice crystals. The remaining liquid reaction product is analyzed and found to comprise sodium N-piperazineethanesulfonate. Further reaction with 44 grams of ethylene oxide (1 mole) at ambient conditions results in the formation of sodium N'-hydroxyethyl-N-piperazineethanesulfonate.

後処理

  1. customAs the reaction progresses
  2. customis collected as ice crystals upon the cold finger trap
  3. customafter which approximately 38 percent by weight of the reactants (about 127 grams) in the reaction vessel have collected upon the cold finger trap as ice crystals
  4. customThe remaining liquid reaction product

出典と根拠

ORDレコード
ord-271630b7482b451f94d5d81ab50da86f
出典データセット
uspto-grants-1986_01
特許番号
US04563291

関連ノート

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