2-Chloromethyl 2-(trimethylsilyl)ethyl ether (HCID 2724271)

名称と識別子

優先名称: 2-Chloromethyl 2-(trimethylsilyl)ethyl ether
IUPAC: 2-(chloromethoxy)ethyl-trimethylsilane
現地名: 2-(クロロメトキシ)エチルトリメチルシラン
英語名: 2-(Trimethylsilyl)ethoxymethyl chloride
分子式: C6H15ClOSi
分子量: 166.72

名称と別名

76513-69-42-(Trimethylsilyl)ethoxymethyl chloride2-Chloromethyl 2-(trimethylsilyl)ethyl etherSILANE, [2-(CHLOROMETHOXY)ETHYL]TRIMETHYL-EINECS 278-483-4DTXSID10227327Silane, (2-(chloromethoxy)ethyl)trimethyl-RefChem:470470DTXCID10149818Silane, 2-(chloromethoxy)ethyltrimethyl-278-483-4(2-(CHLOROMETHOXY)ETHYL)TRIMETHYLSILANE

名称をさらに表示

2-(クロロメトキシ)エチルトリメチルシラン2-(トリメチルシリル)エチル(クロロメチル)エーテルクロロメチル2-(トリメチルシリル)エチルエーテル[2-(トリメチルシリル)エチル](クロロメチル)エーテル2-(トリメチルシリル)エトキシメチルクロリド塩化2-(トリメチルシリル)エトキシメチルSEM-クロリド2‐(トリメチルシリル)エトキシメチルクロリド(2-クロロメトキシエチル)トリメチルシラン, TECH.(2-(クロロメトキシ)エチル)トリメチルシラン[2-(クロロメトキシ)エチル]トリメチルシランSEM-CI(2-trimethylethylsilylethoxy)methyl chloride2-(CHLOROMETHOXY)ETHYLTRIMETHYLSILANE(Trimethylsilyl)ethoxymethyl chloride{2-[(chloromethyl)oxy]ethyl}(trimethyl)silaneDK8912-(Trime

SEM-chloride2-(Trimethylsilyl)ethoxymethylchlorideSEM-Cl[2-(chloromethoxy)ethyl]trimethylsilane2-(chloromethoxy)ethyl-trimethylsilaneMFCD00009919C6H15ClOSiSEM chloride

データベース識別子

CAS: 76513-69-4
PubChem CID: 2724271
DTXSID: DTXSID10227327
UNII: G8Q8Y64LT8
EC Number: 278-483-4
Nikkaji: J319.335G

物性

構造計算による物性

極性表面積: 9.2 Å²
水素結合供与体数: 0
水素結合受容体数: 1
回転可能結合数: 4
重原子数: 9
形式電荷: 0
複雑度: 69.9

物理化学的性質

沸点: 170 · 170-172 °C (lit.) 57-59 °C/8 mmHg (lit.)
比重(密度): 0.942 g/mL · 0.942 g/mL at 25 °C (lit.)
屈折率: 20 · n20/D 1.435(lit.)
闪点: 116 °F · 116 °F
貯蔵温度: 2 · 2-8°C
溶解性: ほとんどの有機溶媒 (ペンタン、CH2Cl2、Et2O、THF、DMF、DMPU、HMPA) に可溶
外見: 液体
色: 無色透明
比重: 0.95 · 0.95
水溶解度: 分解する
BRN: 3587289 · 3587289
安定性: Unstable in Solution
InChI: 1S/C6H15ClOSi/c1-9(2,3)5-4-8-6-7/h4-6H2,1-3H3
InChIKey: BPXKZEMBEZGUAH-UHFFFAOYSA-N
SMILES: C[Si](C)(C)CCOCCl
CAS データベース: 76513 · 76513-69-4(CAS DataBase Reference)

化学的性質

化学的特性Colorless to light yellow liqui

安全と法規制

GHS分類

GHS Classification · 4 件

Danger

H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]

P210, P233, P240, P241, P242, P243, P260, P264, P264+P265, P280, P301+P330+P331, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P321, P363, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 49 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

危険有害性情報

Regulatory Information · 2 件

Status: Active Update: 27-03-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/34974

Silane, 2-(chloromethoxy)ethyltrimethyl-: Does not have an individual approval but may be used under an appropriate group standard

Hazard Classes and CategoriesFlam. Liq. 3 (100%)

安全データ

F: 8-10-21
wgk: 3
tsca: No
ridadr: UN 2920 8/PG 2
hs_code: 29319090
risk_code: 10-34
消防法: 危-4-2-III
hazard_code: C
safety_code: 26-28-36/37/39-45-16
hazard_class: 3.2
packing_group: III
Hazard Classifications: Flam. Liq. 3Skin Corr. 1B
ストレージクラス: 3 - Flammable liquids

化学と産業

応用分野 · 2 件

使用2-(Trimethylsilyl)ethoxymethyl Chloride is a reagent used in the protection of alcohols, secondary aryl amines, and imidazole, indole, and pyrrole nitrogens;electrophilic formaldehyde equivalent; acyl anion equivalent,used in One-carbon Homologations, Cyclizations etc.

一般的な説明2-(Trimethylsilyl)ethoxymethyl chloride (SEM-Cl) is a widely used reagent for the preparation protection groups for amines, alcohols, phenols, and carboxy groups. The nitrogen of amides and sulfonamides groups are also protected by using SEM-Cl reagent.

調製方法 · 1 件

純化方法Dissolve SEMCl in pentane, dry it (MgSO4), evaporate and distil the residual oil in a vacuum. Stabilise it with 10ppm of diisopropylamine. Store it under N2 in a sealed container in a refrigerator. [Lipshutz & Pegram Tetrahedron Lett 21 3343 1980.]