Sodium hydride → 5-tert-butyl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole
反応式
[C:1]([C:5]1[NH:9][CH:8]=[N:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[H-].[Na+].[CH3:12][Si:13]([CH2:16][CH2:17][O:18][CH2:19]Cl)([CH3:15])[CH3:14]>>[C:1]([C:5]1[N:9]([CH2:19][O:18][CH2:17][CH2:16][Si:13]([CH3:15])([CH3:14])[CH3:12])[CH:8]=[N:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]参加物
4
実験手順
Reaction of 5-tert-butyl-1H-imidazole (423 mg, 3.41 mmol), NaH (60%, 132 mg, 3.31 mmol), and SEMCl (639 uL, 3.61 mmol) followed by column chromatography on silica gel (hexane/EtOAC 3:2) gave the title compound (500 mg, 57%) as a yellow oil. 1H NMR (300 MHz, CDCl3) δ major isomer: 0.00 (s, 9H), 0.89 (t, 2H, J=7.5 Hz), 1.29 (s, 9H), 3.47 (t, 2H, J=7.5 Hz), 5.19 (s, 2H), 6.73 (s, 1H), 7.50 (s, 1H).
出典と根拠
- ORDレコード
- ord-80ab18e9c9bf4fefb0d2677227570bf5
- 出典データセット
- uspto-grants-2006_08
- 特許番号
- US07084155B2
反応ノート
読み込み中…