Diethylenetriaminepentaacetic acid

Pharmaceuticals

Pharmaceuticals -> Listed in ZINC15

Cosmetic ingredients (Pentetic Acid) -> CIR (Cosmetic Ingredient Review)

Chelating

219-220 ºC

219 °C

CBI; Dry Powder

White to off-white solid; [Acros Organics MSDS]

Danger

H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]

P203, P260, P261, P264+P265, P271, P280, P304+P340, P305+P351+P338, P317, P318, P319, P337+P317, P405, and P501 (click each P-code to see the statement)

This chemical does not meet GHS hazard criteria for 1.3% (7 of 530) of reports.

Danger

H319 (98.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

Chemical: Glycine, N,N-bis[2-[bis(carboxymethyl)amino]ethyl]-

Hazard Traits - Reproductive Toxicity

Glycine, N,N-bis[2-[bis(carboxymethyl)amino]ethyl]- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Glycine, N,N-bis[2-[bis(carboxymethyl)amino]ethyl]- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 24-09-2021 https://echa.europa.eu/registration-dossier/-/registered-dossier/13561

Pentetic acid: Does not have an individual approval but may be used under an appropriate group standard

The calcium salt causes fetal death and teratogenic effects in mice (thought to be associated with the chelation of essential divalent cations such as zinc); [REPROTOX] Causes convulsions and chronic pulmonary edema in intraperitoneal lethal-dose studies of rats (LD50 = 587 mg/kg); [RTECS] An eye irritant; [Acros Organics MSDS] See Edetic acid.

Eye Irrit. 2 (98.7%)

Acute toxicity (inhalation) - category 4

Acute toxicity (Inhalation: Dusts and mists) - Category 4

Repr. 1B

3.5 [mg/m3]

39 [mg/m3]

230 [mg/m3]

Reproductive Toxin - A chemical that is toxic to the reproductive system, including defects in the progeny and injury to male or female reproductive function. Reproductive toxicity includes developmental effects. See Guidelines for Reproductive Toxicity Risk Assessment.

Drug-Induced Liver Injury Severity and Toxicity (DILIst)

pentetic acid

DILI Negative

Intravenous

DOI:10.1016/j.drudis.2019.09.022

There are reports in vivo of low stability of complexes of DPTA with uranium and neptunium which is being reported to cause deposition of the radionuclides into the tissues. In the case of plutonium, some preclinical studies have shown a very high urine elimination efficacy 1 hour after initial contamination. This efficacy is conserved for approximately 24 hours while the radiocontaminant is circulating. When the radionuclide is inhaled, it has been reported a DPTA-induced reduction of even 98% of the lung deposits. It is important to consider that pentetic acid can bind directly to other trace metals in the body which can cause deficiencies.

The calcium and zinc trisodium salts of DTPA achieve the therapeutical potential by exchanging calcium and zinc cations with transuranic radionuclides to form higher affinity complexes and then promote their elimination by glomerular filtration into the urine. DTPA as an acid acts in a very similar way by sequestering ions with its eight coordinate bond forming sites.

7A314HQM0I

PENTETIC ACID

Mechanisms of Action [MoA] - Lead Chelating Activity

Established Pharmacologic Class [EPC] - Lead Chelator

Pentetic acid is a Lead Chelator. The mechanism of action of pentetic acid is as a Lead Chelating Activity.

KIT FOR THE PREPARATION OF TECHNETIUM TC 99M PENTETATE

Agents counteracting or neutralizing the action of POISONS.

Chemicals that bind to and remove ions from solutions. Many chelating agents function through the formation of COORDINATION COMPLEXES with METALS.

Organic chemicals that form two or more coordination links with an iron ion. Once coordination has occurred, the complex formed is called a chelate. The iron-binding porphyrin group of hemoglobin is an example of a metal chelate found in biological systems.

DTPA and its trisodium salts present a very poor bioavailability after oral administration. Therefore, the normal administration of DTPA is done by slow intravenous infusion or inhalation with a nebulizer. When inhaled, the absorption is of about 20% of the administered dose.

DTPA metal complexes are quickly excreted in the urine.It is predominantly excreted by the kidney and it is not excreted by non-renal routes to any significant extent.

The volume of distribution of DPTA is 17 L.

Pentetic acid presents a very rapid blood clearance which explains for the short half-life. The reported clearance rate in patients with normal renal function is 80-120ml/min.

CIR ingredient: Pentetic Acid

Used as a chelating agent; [Merck Index] An iron chelating agent with properties like EDETIC ACID. DTPA has also been used as a chelator for other metals, such as plutonium. [ChemIDplus] Used in cosmetic products, in industrial metal extraction, and therapeutically; [ExPub: TERIS]

Metal Extraction and Refining [Category: Industry]

CBI

Glycine, N,N-bis[2-[bis(carboxymethyl)amino]ethyl]-: ACTIVE