Flecainide Acetate

HCID 41022CAS 54143-56-5

基本情報

標準SMILES: CC(=O)O.O=C(NCC1CCCCN1)c1cc(OCC(F)(F)F)ccc1OCC(F)(F)F
InChIKey: RKXNZRPQSOPPRN-UHFFFAOYSA-N
分子式: C19H24F6N2O5
平均分子量: 474.4 g/mol
単同位体質量: 474.15894119

概要

Flecainide acetate is an acetate salt obtained by combining flecainide with one molar equivalent of acetic acid. An antiarrhythmic agent used to prevent and treat tachyarrhythmia (abnormal fast rhythm of the heart). It has a role as an anti-arrhythmia drug. It contains a flecainide(1+).

名称と識別子

優先名称: Flecainide Acetate
IUPAC: acetic acid;N-(piperidin-2-ylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide

名称と別名

Flecainide acetate54143-56-5FLECAINIDE MONOACETATER-818R 818DTXSID8020626M8U465Q1WQBenzamide, N-(2-piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)-, monoacetateDTXCID80626CHEBI:5091NSC719273RefChem:56567

名称をさらに表示

Flecainide Acetate TabletN-((2RS)-Piperidin-2-ylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide monoacetateTambocorFlecainide (acetate)MFCD00214290N-(2-Piperidylmethyl)-2,5-bis-(2,2,2-trifluoroethoxy)benzamide acetaten-(piperidin-2-ylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide acetateMLS000069675

データベース識別子

CAS: 54143-56-5
PubChem CID: 41022
DTXSID: DTXSID8020626
ChEMBL: CHEMBL1200822
ChEBI: CHEBI:5091
UNII: M8U465Q1WQ
EC Number: 258-997-5

物性

構造計算による物性

極性表面積: 96.9 Å²
水素結合供与体数: 3
水素結合受容体数: 12
回転可能結合数: 7
重原子数: 32
形式電荷: 0
複雑度: 531

実験および物理化学的性質

Solubility>71.2 [ug/mL] (The mean of the results at pH 7.4)

Human Drugs · 2 件

FDA approved drugs -> Active ingredient

安全と法規制

GHS分類

GHS Classification · 4 件

Danger

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

P203, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P318, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 47 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

危険有害性情報

Regulatory InformationFlecainide acetate: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

Hazard Classes and CategoriesAcute Tox. 4 (100%)

毒性情報

Drug Induced Liver Injury · 6 件

Drug Induced Liver Injury Rank (DILIrank 2.0)

Flecainide acetate

vLess-DILI-concern

Adverse reactions

DOI:10.1016/j.drudis.2016.02.015

化学と産業

薬理情報

FDA Pharmacological Classification · 4 件

FLECAINIDE ACETATE

Antiarrhythmic [EPC]

FLECAINIDE ACETATE TABLET

Antiarrhythmic [EPC]

MeSH Pharmacological Classification · 2 件

Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.

A class of drugs that inhibit the activation of VOLTAGE-GATED SODIUM CHANNELS.