CAS 55-31-2 (-)-Epinephrine hydrochloride (HCID 441411)

概要

Crystals. Used medically as a cardiostimulant.

名称と識別子

優先名称: (-)-Epinephrine hydrochloride
IUPAC: 4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol;hydrochloride
現地名: 塩酸エピネフリン
英語名: Epinephrine Hydrochloride
分子式: C9H14ClNO3
分子量: 219.67

名称と別名

Epinephrine hydrochloride55-31-2Epinephrine HClAdrenaline hydrochlorideAdrenalin chlorideAdrenaline chlorideEpinephrine chloridel-Adrenaline chloridel-Epinephrine chlorideAdrenalin hydrochloridel-Adrenaline hydrochlorideNCI-C55663

名称をさらに表示

(-)-アドレナリン塩酸塩塩酸アドレナリン塩酸エピネフリンスプラレニン塩酸塩アドレナリン塩酸塩エピネフリン塩酸塩4-[(R)-1-ヒドロキシ-2-(メチルアミノ)エチル]-1,2-ベンゼンジオール·塩酸塩アドレナリン·塩酸塩塩酸エピネフリン (JAN)l-epinephrine hydrochlorideL-Epinephrine HClZeatin Impurity 19epinephrinechloridegelatin-epinephrinesupranephrinsolutionL-Epinephrine hydroc

WBB047OO381,2-Benzenediol, 4-(1-hydroxy-2-(methylamino)ethyl)-, hydrochloride, (R)-l-1-(3,4-Dihydroxyphenyl)-2-methylamino-1-ethanol hydrochloride1,2-Benzenediol, 4-[(1R)-1-hydroxy-2-(methylamino)ethyl]-, hydrochlorideBenzyl alcohol, 3,4-dihydroxy-alpha-((methylamino)methyl)-, hydrochloride, (-)-1,2-Benzenediol, 4-((1R)-1-hydroxy-2-(methylamino)ethyl)-, hydrochlorideCHEBI:6213Orostat 8%

データベース識別子

CAS: 55-31-2
PubChem CID: 441411
DTXSID: DTXSID1020568
ChEMBL: CHEMBL3183376
UNII: WBB047OO38
EC Number: 200-230-3

物性

構造計算による物性

極性表面積: 72.7 Å²
水素結合供与体数: 5
水素結合受容体数: 4
回転可能結合数: 3
重原子数: 14
形式電荷: 0
複雑度: 154

実験および物理化学的性質

Human DrugsBreast Feeding; Lactation; Milk, Human; Adrenergic Agonists; Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Antiglaucoma Agents; Bronchodilator Agents; Catecholamines; Mydriatics; Sympathomimetics; Vasoconstrictor Agents

Melting Point315 °F (NTP, 1992)

Physical DescriptionCrystals. Used medically as a cardiostimulant.

物理化学的性質

融点: 157 °C · 157°C
貯蔵温度: -20 °C · Store at -20°C
溶解性: 10 mM · Soluble in DMSO > 10 mM
外見: Powder
InChI: InChI=1/C9H13NO3.ClH/c1-10-5-9(13)6-2-3-7(11)8(12)4-6;/h2-4,9-13H,5H2,1H3;1H/t9-;/s3
InChIKey: ATADHKWKHYVBTJ-OVMXBOEKNA-N
SMILES: [C@H](C1C=CC(O)=C(O)C=1)(O)CNC.Cl |&1:0,r|
CAS データベース: 55 · 55-31-2(CAS DataBase Reference)
EPAの化学物質情報: Epinephrine hydrochloride (55-31-2)

安全と法規制

危険有害性情報

Regulatory Information1,2-Benzenediol, 4-(1R)-1-hydroxy-2-(methylamino)ethyl-, hydrochloride: Does not have an individual approval but may be used under an appropriate group standard

DOT LabelPoison

Fire HazardsFlash point data for this chemical are not available, but it is probably combustible. (NTP, 1992)

Health HazardsSYMPTOMS: Adverse reactions include restlessness; anxiety; headache; tremor; weakness; dizziness; pallor; respiratory difficulties; palpitation; nausea and vomiting. (NTP, 1992)

Reactive GroupAlcohols and Polyols

Reactivity ProfileEPINEPHRINE HYDROCHLORIDE is readily destroyed by alkalis and oxidizing agents (NTP, 1992).

安全と保護具

Fire FightingFires involving this compound should be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

First Aid · 1 件

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Nonfire Spill Response · 1 件

SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a strong soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

Isolation and EvacuationExcerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:

Personal Protective Equipment (PPE) · 1 件

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter). (NTP, 1992)

毒性情報

Carcinogen Classification · 6 件

Epinephrine Hydrochloride

TR-380: Toxicology and Carcinogenesis Studies of l-Epinephrine Hydrochloride (CASRN 55-31-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) (1990 )

11/20/89

Inadequate Experiment

Effects During Pregnancy and Lactation◉ Summary of Use during Lactation

安全データ

ridadr: 3249
hazard_class: 6.1(a)
packing_group: II

化学と産業

薬理情報

FDA Pharmacological Classification · 2 件

EPINEPHRINE HYDROCHLORIDE

Adrenergic beta-Agonists [MoA]; Adrenergic alpha-Agonists [MoA]; Catecholamines [CS]; Catecholamine [EPC]; alpha-Adrenergic Agonist [EPC]; beta-Adrenergic Agonist [EPC]

MeSH Pharmacological Classification · 6 件

Drugs that selectively bind to and activate alpha adrenergic receptors.

Drugs that selectively bind to and activate beta-adrenergic receptors.

Agents that cause an increase in the expansion of a bronchus or bronchial tubes.

Agents that dilate the pupil. They may be either sympathomimetics or parasympatholytics.

Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters.

Drugs used to cause constriction of the blood vessels.

応用分野

一般的な説明Crystals. Used medically as a cardiostimulant.

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化合物ノート

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塩酸エピネフリン

基本情報

概要