Terazosin Hydrochloride Anhydrous

HCID 44383CAS 63074-08-8

部分構造検索類似構造を探す

基本情報

標準SMILES: COc1cc2nc(N3CCN(C(=O)C4CCCO4)CC3)nc(N)c2cc1OC.Cl
InChIKey: IWSWDOUXSCRCKW-UHFFFAOYSA-N
分子式: C19H26ClN5O4
平均分子量: 423.9 g/mol
単同位体質量: 423.16733199

概要

See also: Terazosin (has active moiety); Terazosin Hydrochloride (annotation moved to).

名称と識別子

優先名称: Terazosin Hydrochloride Anhydrous
IUPAC: [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(oxolan-2-yl)methanone;hydrochloride

名称と別名

63074-08-8Terazosin HClTerazosin hydrochloride anhydrousPiperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetrahydro-2-furanyl)carbonyl)-, monohydrochloride8QOP8Z9955ABBOTT-45975 ANHYDROUSRefChem:932721613-138-7HytrinVasocard(4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)(tetrahydrofuran-2-yl)methanone hydrochlorideMLS000040261

名称をさらに表示

Terazosin (hydrochloride)ZayaselMFCD004679656,7-dimethoxy-2-[4-(oxolane-2-carbonyl)piperazin-1-yl]quinazolin-4-amine hydrochloridePiperazine,1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]-, monohydrochlorideSMR000044015Prazosin Tetrahydro Impurity1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]piperazine hydrochloride

データベース識別子

CAS: 63074-08-8、70024-40-7
PubChem CID: 44383
DTXSID: DTXSID7045493
ChEMBL: CHEMBL1256665
UNII: 8QOP8Z9955
EC Number: 613-138-7

物性

構造計算による物性

極性表面積: 103 Å²
水素結合供与体数: 2
水素結合受容体数: 8
回転可能結合数: 4
重原子数: 29
形式電荷: 0
複雑度: 544

実験および物理化学的性質

Collision Cross Section195.7 Å² [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

安全と法規制

GHS分類

GHS Classification · 5 件

This chemical does not meet GHS hazard criteria for 25% (1 of 4) of reports.

Warning

H302 (50%): Harmful if swallowed [Warning Acute toxicity, oral]

P203, P264, P264+P265, P270, P280, P301+P317, P305+P351+P338, P318, P330, P337+P317, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 4 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

危険有害性情報

Hazard Classes and CategoriesAcute Tox. 4 (50%)

化学と産業

薬理情報

MeSH Pharmacological Classification · 2 件

Drugs that bind to and block the activation of ADRENERGIC ALPHA-1 RECEPTORS.

Drugs used in the treatment of urological conditions and diseases such as URINARY INCONTINENCE and URINARY TRACT INFECTIONS.

用途と製造

UsesUse (kg; approx.) in Germany (2009): >75