2-Chloro-6,7-dimethoxy-4-quinazolinamine → Terazosin Hydrochloride Anhydrous

HRID 428361

反応式

HRID 428361 の反応式
[O:1]1[CH2:5][CH2:4][CH2:3][CH:2]1[C:6]([N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)=[O:7].[NH2:14][C:15]1[C:24]2[C:19](=[CH:20][C:21]([O:27][CH3:28])=[C:22]([O:25][CH3:26])[CH:23]=2)[N:18]=[C:17]([Cl:29])[N:16]=1>>[CH3:26][O:25][C:22]1[CH:23]=[C:24]2[C:15]([NH2:14])=[N:16][C:17]([N:11]3[CH2:10][CH2:9][N:8]([C:6]([CH:2]4[O:1][CH2:5][CH2:4][CH2:3]4)=[O:7])[CH2:13][CH2:12]3)=[N:18][C:19]2=[CH:20][C:21]=1[O:27][CH3:28].[ClH:29]

参加物

3

反応物 2

HCID 902352-Chloro-6,7-dimethoxy-4-quinazolinamineHCID 27346411-(Tetrahydro-2-furoyl)piperazine

生成物 1

HCID 44383Terazosin Hydrochloride Anhydrous収率 73.3%

実験手順

The procedures of Example 9 were followed except that Compound 3 from Example 1 (3.0 grams, 16.3 mmole) and 4-amino-2-chloro-6,7-bismethoxy quinazoline III (3.8 grams, 16.1 mmole) were reacted to obtain 5.0 grams of Terazosin hydrochloride (Yield: 73%). After alkalification, 4.7 grams of white Terazosin solid was obtained.

後処理

  1. customwere reacted

出典と根拠

ORDレコード
ord-d20a34aff01f44b8851f5a208e4967f6
出典データセット
uspto-grants-2001_11
特許番号
US06313293B1

関連ノート

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