ギンセノシドRg3

説明Ginsenoside Rg3 is mainly derived from the dried roots of Araliaceae Panax ginseng C.A.Mey. and Panax quinquefolius L.Ginseng has a long history of medicinal uses, well known as “king of herbs.” Ginseng is listed as the top grade in “Shen Nong’s herbal class,” with “the main security set up the five internal organs, spirit, soul, stop fright, in addition to evil, eyesight, fun puzzle” account. The traditional Chinese medicine regards ginseng as the top grade of reinforcing Qi, with Dabu strength, spleen and lungs, Sheng Jin, Anshen Yizhi, etc.

来歴Ginseng is currently one of the most studied traditional medicines. Chemical researches certificate that ginseng contains a variety of ginseng saponin, ginseng polysaccharide, protein, polypeptide, amino acids, and other chemical constituents. Ginseng saponins are the main active components, accounting for about 4%. Ginsenoside is a kind of sterol compound, which has a similar basic structure. Ginsenoside contains the steroid nucleus of 17 carbon atoms arranged in 4 rings. At present, more than 40 kinds of ginsenosides have been isolated from ginseng. They are divided into four types according to their chemical structure, the protopanaxadiol, the protopanaxatriol, the ocotillol, and the oleanolic acid.Ginsenoside Rg3 is a dammarane tetracyclic triterpenoid saponin found in natural ginseng, which belongs to the protopanaxadiol . It is also the natural ingredient with prominent activity extracted from red ginseng (processed ginseng). Modern medicine has proved that Rg3 has certain biological activity. Since 1983, Rg3 has been widely studied by many scholars in the world . The results showed that the content of ginsenoside Rg3 in the fresh and dried ginseng roots was less than 1 ppm while in red ginseng was 3/100,000. After several years of research, the method of extracting 20(R)-ginsenoside Rg3 from red ginseng has been successfully improved, and the industrialized production has been realized. A multicenter clinical study by eight domestic hospitals indicated that 20(R)-ginsenoside Rg3 has therapeutic effects on tumor. It has been issued the new drug certificate by the Chinese Food and Drug Administration, as a new anticancer drug approved.

使用20(R)-Ginsenoside Rg3 causes an inhibition of phosphatidylinositol 3-kinase/Akt activation that, in turn, results in modulations in Bcl-2 family proteins in such a way that the apoptosis of U87 cells are regulated. Elicits a significant inhibition of in vitro cell adhesion and invasion of U87 cells. in vitro stereoselective inhibition of ginsenosides toward UDP-glucuronosyltransferase isoforms and in vivo inhibition of tumor angiogenesis of lung cancer.