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llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
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R-Ginsenoside Rg3 → Ginsenoside Rg3

HRID 450955
ノート
印刷プレビュー

反応式

HRID 450955 の反応式
[CH3:1][C:2]([CH3:55])=[CH:3][CH2:4][CH2:5][C@@:6]([OH:54])([C@@H:8]1[C@H:12]2[C@H:13]([OH:52])[CH2:14][C@@H:15]3[C@@:20]4([CH3:50])[CH2:21][CH2:22][C@H:23]([O:27][C@@H:28]5[O:33][C@H:32]([CH2:34][OH:35])[C@@H:31]([OH:36])[C@H:30]([OH:37])[C@H:29]5[O:38][C@@H:39]5[O:44][C@H:43]([CH2:45][OH:46])[C@@H:42]([OH:47])[C@H:41]([OH:48])[C@H:40]5[OH:49])[C:24]([CH3:26])([CH3:25])[C@@H:19]4[CH2:18][CH2:17][C@@:16]3([CH3:51])[C@:11]2([CH3:53])[CH2:10][CH2:9]1)[CH3:7]>O>[CH3:1][C:2]([CH3:55])=[CH:3][CH2:4][CH2:5][C@:6]([OH:54])([C@@H:8]1[C@H:12]2[C@H:13]([OH:52])[CH2:14][C@@H:15]3[C@@:20]4([CH3:50])[CH2:21][CH2:22][C@H:23]([O:27][C@@H:28]5[O:33][C@H:32]([CH2:34][OH:35])[C@@H:31]([OH:36])[C@H:30]([OH:37])[C@H:29]5[O:38][C@@H:39]5[O:44][C@H:43]([CH2:45][OH:46])[C@@H:42]([OH:47])[C@H:41]([OH:48])[C@H:40]5[OH:49])[C:24]([CH3:25])([CH3:26])[C@@H:19]4[CH2:18][CH2:17][C@@:16]3([CH3:51])[C@:11]2([CH3:53])[CH2:10][CH2:9]1)[CH3:7]
参加物実験手順後処理出典と根拠反応ノート

参加物

3

反応物 1

HCID 46887680R-Ginsenoside Rg3

生成物 1

HCID 9918693Ginsenoside Rg3

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

Take 100 ml of 20(R)-ginsenoside Rg3 composition solution obtained from Operation Example 1, add water for injection to 1000 ml, and add 0.1 grams of injection grade active carbon and mix to uniformity. Leave it at 80° C. for 30 minutes, remove the pyrogen with 0.45 μm micropore membrane filtering, sterilize with a 0.22 μm micropore filter membrane under sterile conditions, dispense into a 10 ml sterile antibiotics tube vial under sterile conditions, and the quantity of each tube vial is 4.5˜4.9 ml:5 mg. After the dispensed, the antibiotics tube vials are half-corked, they are transferred onto the plate of lyophilizer (LYO-5, manufactured in Shanghai). Close the door of the lyophilizer, turn on the lyophilizer and first freeze to below −40° C. and keep for 4 hours, and then start vacuum drying as following program for sublimation: −45˜−30° C. for 4 hours, −30˜−20° C. for 4 hours, −20˜−15° C. for 2 hours. Finally, dry for 4 hours at 15˜30° C., and the lyophilization process is complete. After lyophilization, the corks are fully plugged and aluminum covers are pressed on with a sealing machine. Sample some sample for testing. Pack the qualified tube vials. 1000 tube vials of lyophilized powder for injection (3.1 mg Rg3/vial) are obtained. The above-mentioned procedures can be carried out for Example 2-40 to produce water-soluble powder of ginsenoside Rg3.

後処理

  1. additionadd 0.1 grams of injection grade active carbon
  2. additionmix to uniformity
  3. customLeave it at 80° C. for 30 minutes
  4. customremove the pyrogen with 0.45 μm micropore membrane
  5. filtrationfiltering
  6. filtrationsterilize with a 0.22 μm micropore filter membrane under sterile conditions, dispense into a 10 ml sterile antibiotics tube vial under sterile conditions
  7. customthe quantity of each tube vial is
  8. customClose the door of the lyophilizer, turn on the lyophilizer and first freeze to below −40° C.
  9. customdrying
  10. wait−45˜−30° C. for 4 hours
  11. wait−30˜−20° C. for 4 hours
  12. wait−20˜−15° C. for 2 hours
  13. customFinally, dry for 4 hours at 15˜30° C.
  14. custom1000 tube vials of lyophilized powder for injection (3.1 mg Rg3/vial) are obtained

出典と根拠

ORDレコード
ord-78dc4b1afbbf46b08f1e4c98e3cc40b3
出典データセット
uspto-grants-2013_07
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US08487090B2

反応ノート

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