基本情報
- CAS
66794-74-9- 標準SMILES
COc1ccc(C(=O)Nc2ccccc2CCC2CCCCN2C)cc1.Cl- InChIKey
OJIIZIWOLTYOBS-UHFFFAOYSA-N- 分子式
- C22H29ClN2O2
- 平均分子量
- 388.9 g/mol
- 単同位体質量
- 388.1917559
概要
Encainide hydrochloride is the hydrochloride salt of encainide. A class Ic antiarrhythmic, it was used for the treatment of severe or life-threatening ventricular arrhythmias, but it was associated with increased death rates in patients who had asymptomatic heart rhythm abnormalities after a recent heart attack and was withdrawn from the market. It has a role as an anti-arrhythmia drug. It contains an encainide.
名称と識別子
- 優先名称
- Encainide Hydrochloride
- IUPAC
- 4-methoxy-N-[2-[2-(1-methylpiperidin-2-yl)ethyl]phenyl]benzamide;hydrochloride
- 現地名
- エンカイニド 塩酸塩
- 英語名
- Encainide hydrochloride
- 分子式
- C22H28N2O2.ClH
- 分子量
- 388.936
名称と別名
Encainide hydrochloride66794-74-9Encainide HClMJ 9067-1DTXSID2049004MJ-90674CH7J36N9S4-Methoxy-2'-(2-(1-methyl-2-piperidyl)ethyl)benzanilide hydrochlorideMJ-9067-1DTXCID7028930CHEBI:598802-(2-{2-[(4-methoxybenzoyl)amino]phenyl}ethyl)-1-methylpiperidinium chloride
名称をさらに表示
エンカイニド 塩酸塩塩酸エンカイニドエンカイニド塩酸塩エンカイニド・塩酸塩(+)-IsomerEncainide, (+)-Isomer4-methoxy-n-(2-(2-(1-methylpiperidin-2-yl)ethyl)phenyl)benzamide hydrochlorideMJ-9067, (+/-)-4-Methoxy-N-[2-[2-(1-methyl-2-piperidinyl)ethyl]phenyl]benzamide hydrochloride
2-(2-(2-((4-methoxybenzoyl)amino)phenyl)ethyl)-1-methylpiperidinium chlorideRefChem:920938Encainide Hydrochloride, (+-)-MJ9067Benzamide, 4-methoxy-N-(2-(2-(1-methyl-2-piperidinyl)ethyl)phenyl)-, hydrochloride (1:1)636-281-7EnkaidEncainide (hydrochloride)
データベース識別子
- CAS
物性
構造計算による物性
- 極性表面積
- 41.6 Ų
- 水素結合供与体数
- 2
- 水素結合受容体数
- 3
- 回転可能結合数
- 6
- 重原子数
- 27
- 形式電荷
- 0
- 複雑度
- 434
物理化学的性質
- 融点
- 131.5 · 131.5-132.5 °C
- 貯蔵温度
- 2 · 2-8°C
- 溶解性
- 2 O: · H2O: >25mg/mL
- 外見
- 粉
- 色
- White to off-white
- 水溶解度
- 2 O: · H2O: >25mg/mL
- InChI
- 1S/C22H28N2O2.ClH/c1-24-16-6-5-8-19(24)13-10-17-7-3-4-9-21(17)23-22(25)18-11-14-20(26-2)15-12-18;/h3-4,7,9,11-12,14-15,19H,5-6,8,10,13,16H2,1-2H3,(H,23,25);1H
- InChIKey
- OJIIZIWOLTYOBS-UHFFFAOYSA-N
- SMILES
- Cl.COc1ccc(cc1)C(=O)Nc2ccccc2CCC3CCCCN3C
安全と法規制
安全情報は参考情報です。供給元の安全データシート（SDS）、適用法令、専門家による評価に代わるものではありません。
GHS分類
GHS Classification
Danger
H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]
P261, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 39 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
危険有害性情報
Hazard Classes and CategoriesAcute Tox. 3 (100%)
安全データ
- wgk
- 3
- rtecs
- CV5521500
- ridadr
- UN 2811 6.1/PG 3
- 毒性
- LD50 in mice, dogs (mg/kg): 86, 43 orally; 16, 17 i.v. (Mitchell, Winkle)
- risk_code
- 25-36/37/38
- hazard_code
- T
- safety_code
- 26-45
- Hazard Classifications
- Acute Tox. 3 OralEye Irrit. 2Skin Irrit. 2STOT SE 3
- ストレージクラス
- 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
化学と産業
薬理情報
MeSH Pharmacological Classification
Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.
A class of drugs that inhibit the activation of VOLTAGE-GATED SODIUM CHANNELS.
応用分野
説明Encainide is an oral and injectable antiarrhythmic structurally related to flecainide. It is reportedly useful in the treatment of symptomatic and life-threatening ventricular arrhythmias. While it appears to have higher efficacy than quinine, the morbidity and mortality rates are comparable.
使用Cardiac depressant (anti-arrhythmic.
上流・下流製品情報
上流原料
関連反応
3 件
化合物ノート
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