ネドクロミルナトリウム

Nedocromil Sodium

HCID 50295

基本情報

CAS
69049-74-7
標準SMILES
CCCc1c2oc(C(=O)[O-])cc(=O)c2cc2c(=O)cc(C(=O)[O-])n(CC)c12.[Na+].[Na+]
InChIKey
JQEKDNLKIVGXAU-UHFFFAOYSA-L
分子式
C19H15NNa2O7
平均分子量
415.3 g/mol
単同位体質量
415.06439038

名称と識別子

優先名称
Nedocromil Sodium
IUPAC
disodium;9-ethyl-4,6-dioxo-10-propylpyrano[3,2-g]quinoline-2,8-dicarboxylate
現地名
ネドクロミルナトリウム
英語名
NEDOCROMIL SODIUM
分子式
C19H18NNaO7
分子量
395.34

名称と別名

NEDOCROMIL SODIUM69049-74-7TiladeAlocrilTayledFPL 59002KPRapitilTilarinNedocromil disodium saltFPL-59002KPET8IF4KS1TCHEBI:7493
名称をさらに表示
ネドクロミルナトリウム[9-エチル-6,9-ジヒドロ-4,6-ジオキソ-10-プロピル-4H-ピラノ[3,2-g]キノリン]-2,8-ジカルボン酸ジナトリウム2,8-二ナトリウム 9-エチル-4,6-ジオキソ-10-プロピル-4H,6H,9H-クロメノ[7,6-b]ピリジン-2,8-ジカルボキシラートNEDOCROMIL SODIUM###Nedocromil4H-Pyrano[3,2-g]quinoline-2,8-dicarboxylicacid, 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-, sodium salt
4H-Pyrano(3,2-g)quinoline-2,8-dicarboxylic acid, 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-, disodium saltDTXSID00219115RefChem:57534DTXCID20141606620-501-3Sodium 9-ethyl-4,6-dioxo-10-propyl-6,9-dihydro-4H-pyrano[3,2-g]quinoline-2,8-dicarboxylateNedocromil sodium [USAN]UNII-ET8IF4KS1T

データベース識別子

CAS
69049-74-7
PubChem CID
50295
DTXSID
DTXSID00219115
ChEMBL
CHEMBL915
ChEBI
CHEBI:7493
UNII
ET8IF4KS1T
EC Number
620-501-3
Nikkaji
J357.902F

物性

構造計算による物性

極性表面積
127 Ų
水素結合供与体数
0
水素結合受容体数
8
回転可能結合数
3
重原子数
29

物理化学的性質

貯蔵温度
2 · Inert atmosphere,2-8°C
溶解性
2 O: · H2O: 可溶20mg/mL、透明
外見
粉
色
、白からベージュ、茶色
水溶解度
2 O: · H2O: 20mg/mL, clear
InChI
1S/C19H17NO7.2Na/c1-3-5-9-16-10(13(21)7-12(18(23)24)20(16)4-2)6-11-14(22)8-15(19(25)26)27-17(9)11;;/h6-8H,3-5H2,1-2H3,(H,23,24)(H,25,26);;/q;2*+1/p-2

安全と法規制

GHS分類

GHS Classification · 6 件

This chemical does not meet GHS hazard criteria for 16.7% (1 of 6) of reports.

Warning

H315 (33.3%): Causes skin irritation [Warning Skin corrosion/irritation];H319 (83.3%): Causes serious eye irritation [Warning Serious eye damage/eye irritation];H335 (33.3%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 6 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.;Reported as not meeting GHS hazard criteria per 1 of 6 reports by companies.;There are 2 notifications provided by 5 of 6 reports by companies with hazard statement code(s).;Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

危険有害性情報

Other Safety Information · 1 件

IMAP assessments - 4H-Pyrano[3,2-g]quinoline-2,8-dicarboxylic acid, 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-, disodium salt: Human health tier I assessment;IMAP assessments - 4H-Pyrano[3,2-g]quinoline-2,8-dicarboxylic acid, 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-, disodium salt: Environment tier I assessment

Hazard Classes and CategoriesSkin Irrit. 2 (33.3%);Eye Irrit. 2 (83.3%);STOT SE 3 (33.3%)

安全データ

wgk
3
ストレージクラス
11 - Combustible Solids

化学と産業

薬理情報

MeSH Pharmacological Classification · 4 件

Substances that reduce or suppress INFLAMMATION.

Compounds that prevent the release of inflammatory mediators from MAST CELLS.

Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475)

Drugs that are used to treat asthma.

応用分野 · 3 件

説明Nedocromil sodium is an antiallergic agent with broader mast cell stabilizing properties than related cromolyn sodium. Administered as an aerosol, it is useful in the treatment of bronchial asthma and related diseases.

使用Nedocromil Sodium (Technical Grade) is a medication considered as mast cell stabilizer which act to prevent wheezing, shortness of breath, and other breathing problems caused by asthma.

一般的な説明Nedocromil sodium, disodium9-ethyl-6, 9-dihydro-4,6-dioxo-10-propyl-4H-pyrano[3, 2-g]quinoline-2,8-dicarboxylate (Tilade), is structurally relatedto cromolyn and displays similar, but broader, pharmacologicalactions. It was available as an aerosol in ametered-dose inhaler for asthma treatment, and currently remainsavailable as ophthalmic solution for the treatmentof itching associated with allergic conjunctivitis. The inhalationformulation was marketed for maintenance therapyin the management of patients with mild-to-moderatebronchial asthma, but since has been withdrawn.

サプライヤー30 社

陕西缔都新材料有限公司81124267 17392282731 · [email protected]
合肥曼奇诺生物医药技术有限公司19719236623 · [email protected]
杭州品高化工有限公司0571-87658025 · [email protected]
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
Dayang Chem (Hangzhou) Co.,Ltd.+86-0571-88938639 17705817739 · [email protected]

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