Calcium nitrate → Nedocromil Calcium

HRID 231806

反応式

HRID 231806 の反応式
[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][C:9]3[C:19](=[O:20])[CH:18]=[C:17]([C:21]([O-:23])=[O:22])[O:16][C:10]=3[C:11]=2[CH2:13][CH2:14][CH3:15])[C:6](=[O:24])[CH:5]=[C:4]1[C:25]([O-:27])=[O:26])[CH3:2].[Na+].[Na+].[N+]([O-])([O-])=O.[Ca+2:34].[N+]([O-])([O-])=O>O>[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][C:9]3[C:19](=[O:20])[CH:18]=[C:17]([C:21]([O-:23])=[O:22])[O:16][C:10]=3[C:11]=2[CH2:13][CH2:14][CH3:15])[C:6](=[O:24])[CH:5]=[C:4]1[C:25]([O-:27])=[O:26])[CH3:2].[Ca+2:34]

参加物

4

反応物 2

HCID 24963Calcium nitrateHCID 50295Nedocromil Sodium

生成物 1

HCID 68731Nedocromil Calcium収率 98.7%

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

A filtered solution of disodium 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-4H-pyrano-[3,2-g]-quinoline-2,8-dicarboxylate (75 g) in water (500 ml) was treated with a filtered solution of calcium nitrate (77 g) in water (500 ml). The mixture was stirred (2 hours) and then filtered. The solid obtained was washed with water and acetone, slurried first with water and then reslurried with acetone (500 ml). The solid was filtered off and dried in vacuo at 65° C. to give the title compound (73 g, contains 19.3% w/w water).

後処理

  1. filtrationfiltered
  2. customThe solid obtained
  3. washwas washed with water and acetone
  4. filtrationThe solid was filtered off
  5. customdried in vacuo at 65° C.

出典と根拠

ORDレコード
ord-57b3f8b9794a4e8fba9c5aa374d32808
出典データセット
uspto-grants-1989_07
特許番号
US04849427

関連ノート

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