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2-メチル-5-ニトロ安息香酸

2-Methyl-5-nitrobenzoic acid

HCID 519683
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基本情報名称と識別子物性安全と法規制化学と産業関連反応化合物ノート
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基本情報

CAS
1975-52-6
標準SMILES
Cc1ccc([N+](=O)[O-])cc1C(=O)O
InChIKey
DJRFJAVPROZZFL-UHFFFAOYSA-N
分子式
C8H7NO4
平均分子量
181.15 g/mol
単同位体質量
181.0375077

名称と識別子

優先名称
2-Methyl-5-nitrobenzoic acid
IUPAC
2-methyl-5-nitrobenzoic acid
現地名
2-メチル-5-ニトロ安息香酸
英語名
2-Methyl-5-nitrobenzoic acid
分子式
C8H7NO4
分子量
181.15

名称と別名

2-METHYL-5-NITROBENZOIC ACID5-Nitro-o-toluic acidEINECS 217-829-03-Nitro-6-methylbenzoic acidDTXSID2025638RefChem:88179DTXCID805638O-TOLUIC ACID, 5-NITRO-217-829-0DJRFJAVPROZZFL-UHFFFAOYSA-N1975-52-6Benzoic acid, 2-methyl-5-nitro-
名称をさらに表示
2-メチル-5-ニトロ安息香酸5-ニトロ-2-メチル安息香酸5-ニトロ-o-トルイル酸2‐メチル‐5‐ニトロ安息香酸RARECHEM AL BO 02852-Methyl-5-nitrobenz-5-nitrobenzoic acid2-Methyl-5-nitrobenzoic2-Methyl-3-nitrobenzoic
5-nitro-2-methylbenzoic acid2-Methyl-5-nitro-benzoic acidMFCD00007371Diethyl-d10 CarbonateDinitolmide Impurity A2-Methyl-5-nitrobenzoicacid2-Methyl-5-nitro benzoic acidDinitolmide Impurity 3

データベース識別子

CAS
1975-52-6
PubChem CID
519683
DTXSID
DTXSID2025638
ChEMBL
CHEMBL2179896
UNII
V32SF9XBE2
EC Number
217-829-0
Nikkaji
J26.933F

物性

構造計算による物性補完中

XLogP
2.1
極性表面積
83.1 Ų
水素結合供与体数
1
水素結合受容体数
4
回転可能結合数
1
重原子数
13
形式電荷
0
複雑度
223

実験および物理化学的性質

Solubilityless than 1 mg/mL at 72 °F (NTP, 1992)
Melting Point347 to 352 °F (NTP, 1992)
Physical Description2-methyl-5-nitrobenzoic acid appears as needles or beige solid. (NTP, 1992)

物理化学的性質

融点
177 · 177-180 °C (lit.)
沸点
314.24 °C · 314.24°C (rough estimate)
比重(密度)
1.4283 · 1.4283 (rough estimate)
屈折率
1.5468 · 1.5468 (estimate)
貯蔵温度
Sealed in dry,Room Temperature
溶解性
クロロホルム
酸解離定数(Pka)
3.12 · 3.12±0.10(Predicted)
外見
結晶性粉末
色
黄色からベージュ
水溶解度
0.1 g/100 · <0.1 g/100 mL で 22 ºC
BRN
2451300 · 2451300
InChI
InChI=1S/C8H7NO4/c1-5-2-3-6(9(12)13)4-7(5)8(10)11/h2-4H,1H3,(H,10,11)

安全と法規制

安全情報は参考情報です。供給元の安全データシート(SDS)、適用法令、専門家による評価に代わるものではありません。

GHS分類

GHS Classification · 5 件

Warning

H302 (87%): Harmful if swallowed [Warning Acute toxicity, oral];H315 (15.2%): Causes skin irritation [Warning Skin corrosion/irritation];H317 (87%): May cause an allergic skin reaction [Warning Sensitization, Skin];H319 (15.2%): Causes serious eye irritation [Warning Serious eye damage/eye irritation];H335 (13%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P261, P264, P264+P265, P270, P271, P272, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P333+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 46 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.;Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

危険有害性情報

DOT LabelPoison
Fire HazardsFlash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)
Health Hazards · 1 件

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:;TOXIC and/or CORROSIVE; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause environmental contamination. (ERG, 2024)

Reactive GroupAcids, Carboxylic;Nitro, Nitroso, Nitrate, and Nitrite Compounds, Organic

化学と産業

応用分野 · 3 件

用途有機合成原料。

使用2-Methyl-5-nitrobenzoic Acid (cas# 1975-52-6) is a compound useful in organic synthesis.

一般的な説明Needles or beige solid.

上流・下流製品情報

上流原料

2-メチル-5-ニトロ安息香酸メチルテトラヒドロフランリチウムヒドロキシド水和物

下流製品

5-ヨード-2-メチル安息香酸 ヨウ化物6-ニトロイソベンゾフラン-1(3H)-オン2-メチル-3,5-ジニトロ安息香酸2-メチル-5-ニトロ安息香酸メチル5-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-2-methyl-Benzoic acid methyl ester3-iodo-2-methyl-5-nitrobenzoic acid1(2H)-Isoquinolinone, 7-amino-4-bromo-

関連反応

88 件
反応記録を作成
HRID 8913 の反応式
HRID 8913反応物としてuspto-grants-2006_08
HRID 8954 の反応式
HRID 8954反応物としてuspto-grants-2006_08
HRID 146293 の反応式
HRID 146293反応物としてTraining data from https://doi.org/10.1039/C8SC04228D (9/10)
HRID 146324 の反応式
HRID 146324反応物としてTraining data from https://doi.org/10.1039/C8SC04228D (9/10)
HRID 155174 の反応式
HRID 155174反応物としてTraining data from https://doi.org/10.1039/C8SC04228D (9/10)
HRID 160331 の反応式
HRID 160331反応物としてTraining data from https://doi.org/10.1039/C8SC04228D (9/10)
HRID 172338 の反応式
HRID 172338反応物としてTraining data from https://doi.org/10.1039/C8SC04228D (9/10)
HRID 194815 の反応式
HRID 194815反応物としてTraining data from https://doi.org/10.1039/C8SC04228D (6/10)
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化合物ノート

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このページの内容基本情報名称と識別子物性安全と法規制化学と産業関連反応化合物ノート
その他の操作
ノートを作成反応を作成見積依頼を出す
InChIKey
DJRFJAVPROZZFL-UHFFFAOYSA-N
SMILES
C(O)(=O)C1=CC([N+]([O-])=O)=CC=C1C
CAS データベース
1975 · 1975-52-6(CAS DataBase Reference)
NISTの化学物質情報
2 · 2-Methyl-5-nitrobenzoic acid(1975-52-6)
EPAの化学物質情報
2 · 2-Methyl-5-nitrobenzoic acid (1975-52-6)

化学的性質

化学的特性Light Yellow Solid

Reactivity Profile · 1 件

2-METHYL-5-NITROBENZOIC ACID is a nitrated carboxylic acid. Carboxylic acids donate hydrogen ions if a base is present to accept them. They react in this way with all bases, both organic (for example, the amines) and inorganic. Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat. Neutralization between an acid and a base produces water plus a salt. Carboxylic acids with six or fewer carbon atoms are freely or moderately soluble in water; those with more than six carbons are slightly soluble in water. Soluble carboxylic acid dissociate to an extent in water to yield hydrogen ions. The pH of solutions of carboxylic acids is therefore less than 7.0. Many insoluble carboxylic acids react rapidly with aqueous solutions containing a chemical base and dissolve as the neutralization generates a soluble salt. Carboxylic acids in aqueous solution and liquid or molten carboxylic acids can react with active metals to form gaseous hydrogen and a metal salt. Such reactions occur in principle for solid carboxylic acids as well, but are slow if the solid acid remains dry.

Air and Water ReactionsInsoluble in water.
Hazard Classes and CategoriesAcute Tox. 4 (87%);Skin Irrit. 2 (15.2%);Skin Sens. 1 (87%);Eye Irrit. 2A (15.2%);STOT SE 3 (13%)

安全と保護具

Fire FightingFires involving this compound can be controlled with a dry chemical, carbon dioxide, or Halon extinguisher. (NTP, 1992)
First Aid · 1 件

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.;SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.;INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.;INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

Nonfire Spill Response · 1 件

SMALL SPILLS AND LEAKAGE: Should a spill occur while you are handling this chemical, you should dampen the solid spill material with acetone, then transfer the dampened material to a suitable container. Use absorbent paper dampened with acetone to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with acetone followed by washing with a strong soap and water solution. Do not reenter the contaminate area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.;STORAGE PRECAUTIONS: You should store this material in a refrigerator. (NTP, 1992)

Isolation and Evacuation · 1 件

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:;IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.;SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.;FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Personal Protective Equipment (PPE) · 1 件

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

安全データ

wgk
3
ridadr
2811
hs_code
29163900
risk_code
22-43-36/37/38-20/21/22
hazard_code
Xn,Xi
safety_code
37/39-36/37/39-26-22
hazard_class
IRRITANT
Hazard Classifications
Acute Tox. 4 OralSkin Sens. 1
ストレージクラス
11 - Combustible Solids
4-Bromo-7-nitroisoquinolin-1(2H)-one