フィトール

解説フィトール，（化学式)鎖状ジテルペンアルコール，フィチルアルコールともいう。イソプレン単位が4個，頭‐尾結合をした骨格構造をもち，クロロフィル(葉緑素)の構成成分として植物界に広く存在する。クロロフィルaあるいはbをアルカリで加水分解して得ることができる。クロロフィルの分解生成分．葉緑素中にエステルとして存在するジテルペン鎖状アルコール．沸点203～204 ℃(1.3 kPa)．d2540.850．n25D1.463．λmax 212 nm(log ε 3.03)．[α]D＋0.06°(無溶媒)．ビタミンE，Kの合成原料として用いられる．

用途ビタミンEおよびKの合成原料。

説明Phytol is a diterpene alcohol obtained from the degradation of chlorophyll and has been used in the synthesis of Vitamins E and K. During the digestion process of ruminants, phytol is liberated from chlorophyll and converted to phytanic acid to be stored in fats. While humans cannot derive phytol from chlorophyll, free phytol, obtained from the consumption of ruminant adipose tissue and dairy products, is readily absorbed in the small intestine and converted to phytanic acid. Phytanic acid accumulates to toxic levels in a number of metabolic disorders, and the conversion of phytol to phytanic acid has been shown to be regulated via the activation of peroxisome proliferator-activated receptor α (PPARα). Phytol and its metabolites have also been reported to activate retinoid X receptors (RXRs; Kis range from 2.3-67.2 μM) and to promote the activity of PPAR/RXR heterodimers. Phytol also demonstrates sedative and anxiolytic effects through interaction with the GABAA receptor, and it has been explored as an antischistosomal agent in a mouse model of schistosomiasis.

天然物の起源Reported found in Herniaria incana lam oil Greece (2.60%) and Witch hazel leaf oil (9.79%).

使用trans-Phytol is a reagent that is used in the preparation of α-tocopherol analogs as mitochondrial antioxidants. It is also used as a precursor for the manufacture of synthetic forms of vitamin E and vitamin K1.

Phytol can be obtained from natural raw materials by a variety of processes. The industrial synthesis of phytol starts from isophytol. The latter is first treated with formic acid to give phytyl formate, from which (Z, E )-phytol (isomer ratio 3 : 7) is obtained by saponification or transesterification.

定義本品は、次の化学式で表される分岐不飽和脂肪族アルコールである。

定義ChEBI: Phytol is a diterpenoid that is hexadec-2-en-1-ol substituted by methyl groups at positions 3, 7, 11 and 15. It has a role as a plant metabolite, a schistosomicide drug and an algal metabolite. It is a diterpenoid and a long-chain primary fatty alcohol.