Edetate Sodium

Fresh air, rest.

Rinse skin with plenty of water or shower.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Refer for medical attention .

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Wash away remainder with plenty of water.

SRP: The scientific literature for the use of contact lenses by industrial workers is inconsistent. The benefits or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

Tetracycline-HCl absorption in man, given concomitantly with tetra-Na EDTA and milk, showed inhibitory effect of milk counteracted by simultaneous ingestion of EDTA.

Cortisol reduced degree of vascular damage to adrenalectomized rat irrigated with Na4-EDTA salt if administered within 1-6 hr prior to EDTA, no protection if delayed until 15 min prior to EDTA.

LC50; Species: Lepomis macrochirus (Bluegill); Conditions: static, pH 8.9; Concentration: 486 mg/L for 96 hr /Versene powder/

LC50; Species: Lepomis macrochirus (Bluegill) 0.74 (0.62-1.28) g, 34 (28-38) mm; Conditions: static; Concentration: 1,030 mg/L for 96 hr (95% confidence interval: 980-1,080 mg/L) /39.00 % a.i., Versene 100/

LC50; Species: Lepomis macrochirus (Bluegill) weight 0.74 (0.62-1.28) g, length 34 (28-38) mm; Conditions: static; Concentration: 3,092 mg/L for 96 hr (95% confidence interval: 2,320-3,540 mg/L) /41.10 % a.i., Versene FE-3/

LC50; Species: Daphnia magna (Water Flea) age < or = 24 hr; Conditions: freshwater, static, 20-22 °C, pH 7.6-7.7; Concentration: 625000 ug/L for 24 hr /formulation/

Cough. Sore throat.

Redness.

Redness. Pain.

Burning sensation in the throat and chest. Abdominal pain. Diarrhoea.

/HUMAN EXPOSURE STUDIES/ Tetrasodium edetate used in dust as sequestering agent should not be applied to eye unless first neutralized, because it forms solution sufficiently alkaline to be injurious to eye.

/SIGNS AND SYMPTOMS/ Rapid intravenous administration of Na2EDTA causes hypocalcemic tetany. However, a slow infusion (15 mg per minute) administered to a normal individual elicits no symptoms of hypocalcemia because of the ready availability of extracirculatory stores of calcium.

/CASE REPORTS/ A 75-year-old man being treated for several malignant epithelial tumors was prescribed a sunscreen Uriage SPF50+ cream. After 10 months of using the product, the patient presented with eczematous areas where the sunscreen had been applied (face, neck and back of hands). Patch testing was performed with standard series of GEIDAC (Spanish Contact Dermatitis and Cutaneous Allergy Research Group), sunscreen series (Chemotechnique Diagnostics, Malmo, Sweden) and the Uriage SPF50+ cream. After 4 days, a positive reaction was observed to the cream (++). The manufacturer supplied the individual ingredients of their product. Out of the 24 components provided, only tetrasodium ethylenediaminetetraacetic acid (EDTA) 0.2% aqua was positive and it was negative in five controls subjects. ... In our patient, there was a close relation between the application of the sunscreen and the appearance of eczema. Positive patch test was only obtained with 0.2% aqua tetrasodium EDTA as a component of the sunscreen, whereas ethylenediamine was negative. His eczema resolved once the sunscreen ceased to be used. He is now using a mineral-based product without EDTA.

/OTHER TOXICITY INFORMATION/ .../Edetic acid/ and many of its salts bind metal cations tightly and so render them essentially innocuous. /EDTA and its salts/

For more Human Toxicity Excerpts (Complete) data for TETRASODIUM EDTA (6 total), please visit the HSDB record page.

/LABORATORY ANIMALS: Acute Exposure/ Based on limited experimental data and lack of reports of skin and respiratory sensitisation during industrial use of edetic acid and Na4EDTA, the /investigators/ conclude that both edetic acid and Na4EDTA do not cause sensitisation by skin contact or by inhalation. Based on the positive results with the Magnusson-Klingman test, the CSTEE concludes that edetic acid salts may be weak skin sensitizers.

/LABORATORY ANIMALS: Acute Exposure/ Not irritating to skin of rabbits. Irritating to rabbit eyes.

/LABORATORY ANIMALS: Acute Exposure/ Trilon b at 200-400 mg/kg caused tetanic convulsions and death of rabbits and mice.

/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ When administered in drinking water to white mice, EDTA ... and, Tetrasodium EDTA ... produced changes in the mineral content of the tissues. EDTA was administered at a concentration of 3.4 mM (due to its low solubility in water) and the salts were administered at concentrations of 25 mM. The mineral content of bones, kidneys, liver, and muscles was determined using atomic absorption spectrophotometry. ... After treatment with Tetrasodium EDTA, calcium was reduced in bone, liver, and muscle; zinc was reduced in the kidneys, muscle, and liver; and magnesium was reduced in bone and liver. ... Mice given EDTA had increased muscle calcium; and mice treated with Tetrasodium EDTA had increased renal magnesium. Similar results were /previously/ reported after oral administration of 1 mmol/kg/day EDTA for 35 days in a study using 42 male Wistar rats.

For more Non-Human Toxicity Excerpts (Complete) data for TETRASODIUM EDTA (11 total), please visit the HSDB record page.

According to the 2006 TSCA Inventory Update Reporting data, the number of persons reasonably likely to be exposed in the industrial manufacturing, processing, and use of tetrasodium EDTA is 1000 or greater; the data may be greatly underestimated(1).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 1,388,281 workers (611,582 of these were female) were potentially exposed to tetrasodium EDTA in the US(1).

Give ... calcium gluconate ... or ... calcium chloride slowly iv. Repeat as needed every 5 to 10 minutes.

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Poisons A and B/

/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poisons A and B/

/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poisons A and B/

LD50 Mouse ip 330 mg/kg

LD50 Rat ip >2.0 g/kg

LD50 Rat ip 4000 mg/kg bw

Residues of ethylenediaminetetraacetic acid, tetrasodium salt are exempted from the requirement of a tolerance when used in accordance with good agricultural practice as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops or to raw agricultural commodities after harvest. Use: sequestrant. Limit: 5% of pesticide formulation.

Residues of the following chemical substances are exempted from the requirement of a tolerance when used in accordance with good manufacturing practice as ingredients in an antimicrobial pesticide formulation, provided that the substance is applied on a semi-permanent or permanent food-contact surface (other than being applied on food packaging) with adequate draining before contact with food. (a) The following chemical substances when used as ingredients in an antimicrobial pesticide formulation may be applied to: Food-contact surfaces in public eating places, dairy-processing equipment, and food-processing equipment and utensils. Ethylenediaminetetraacetic acid (EDTA), tetrasodium salt is included on this list.

Residues of the following chemical substances are exempted from the requirement of a tolerance when used in accordance with good manufacturing practice as ingredients in an antimicrobial pesticide formulation, provided that the substance is applied on a semi-permanent or permanent food-contact surface (other than being applied on food packaging) with adequate draining before contact with food. ... (c) The following chemical substances when used as ingredients in an antimicrobial pesticide formulation may be applied to: Food-processing equipment and utensils. Ethylenediaminetetraacetic acid (EDTA), tetrasodium salt is included on this list.

As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their continued use. Under this pesticide reregistration program, EPA examines newer health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether the use of the pesticide does not pose unreasonable risk in accordance to newer saftey standards, such as those described in the Food Quality Protection Act of 1996. Pesticides for which EPA had not issued Registration Standards prior to the effective date of FIFRA '88 were divided into three lists based upon their potential for human exposure and other factors, with List B containing pesticides of greater concern than those on List C, and with List C containing pesticides of greater concern than those on List D. Tetrasodium ethylenediaminetetraacetate is found on List D. Case No: 4036; Pesticide type: insecticide, fungicide, herbicide, antimicrobial; Case Status: None of the active ingredients in the case are being supported for reregistration by their registrants. All are unsupported, or some are unsupported and some are cancelled. Cases described as "unsupported" generally are being processed for cancellation.; Active ingredient (AI): tetrasodium ethylenediaminetetraacetate; AI Status: Registrants of the pesticide have not made or honored a commitment to seek reregistration, conduct the necessary studies, or pay the requisite fees, or they have asked EPA to cancel their product registrations. Unless some other interested party supports them, products containing the pesticide will be cancelled.