Edetate Sodium → N-Palmitoylglycine

HRID 521811

反応式

HRID 521811 の反応式
[NH:1]([C:16]([CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32])=[O:17])[CH2:2][C:3](N[C@H](C(O)=O)CC1N=CNC=1)=[O:4].C(N(CC([O-])=O)CC([O-])=O)CN(CC([O-])=O)CC([O-])=[O:38].[Na+].[Na+].[Na+].[Na+]>>[NH:1]([C:16]([CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32])=[O:17])[CH2:2][C:3]([OH:4])=[O:38]

参加物

3

反応物 2

HCID 6144Edetate Sodium2 回HCID 178443076HCID 178443076、化合物2 回

生成物 1

HCID 151008N-Palmitoylglycine

実験手順

N-palmitoyl-Gly-His obtained in the above-described synthesis example was added in a screw bottle (manufactured by Maruemu Corporation) such that the concentration of N-palmitoyl-Gly-His was 1.0 wt % (w/w) and the concentration of an additive (sodium ethylenediaminediacetate, sodium ethylenediaminetetraacetate) was 1.0 wt % (w/w), and a stirring bar (manufactured by As One Corporation, 4 mm×10 mm) was put thereinto. The additives (each having a pH that is outside the range of 6.5 to 9.3 or 1.8 to 2.5) are outside the scope of the present invention. Next, heating and stirring were performed, with a cap of the screw bottle being open, in a water bath (NWB-180N, manufactured by Nissinrika K. K.) for 60 minutes at a maximum until a transparent dispersion state was confirmed at 80° C. After heating and stirring, there were no undissolved residues in the solution with sodium ethylenediaminetetraacetate, whereas undissolved residues were observed by visual inspection in the other.

後処理

  1. temperatureNext, heating
  2. customwith a cap of the screw bottle
  3. custombeing open, in a water bath
  4. temperatureAfter heating
  5. stirringstirring

出典と根拠

ORDレコード
ord-9a71e7efdad948368c8e68564335ae2d
出典データセット
uspto-grants-2016_05
特許番号
US09328137B2

関連ノート

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