D-Lactic Acid (HCID 61503)

概要

(R)-lactic acid is an optically active form of lactic acid having (R)-configuration. It has a role as an Escherichia coli metabolite and a human metabolite. It is a conjugate acid of a (R)-lactate. It is an enantiomer of a (S)-lactic acid.

名称と識別子

優先名称: D-Lactic Acid
IUPAC: (2R)-2-hydroxypropanoic acid
現地名: (R)-2-ヒドロキシプロピオン酸
英語名: (R)-Lactate
分子式: C3H6O3
分子量: 90.08

名称と別名

D-Lactic acid10326-41-7(R)-2-Hydroxypropanoic acidD-(-)-Lactic acid(2R)-2-hydroxypropanoic acid(R)-Lactic acid(-)-Lactic acidPropanoic acid, 2-hydroxy-, (2R)-(R)-2-Hydroxypropionic acid(R)-(-)-Lactic acidD-MilchsaeureD-2-Hydroxypropanoic acid

名称をさらに表示

[R,(-)]-2-ヒドロキシプロピオン酸(-)-乳酸(2R)-2-ヒドロキシプロピオン酸レボギラール(R)-2-ヒドロキシプロパン酸D-乳酸(R)-乳酸D-(-)-乳酸(-)-D-乳酸(R)-2-ヒドロキシプロピオン酸(R)-(-)-乳酸D-(−)-乳酸(R)-ラクトース(2R)-2-ヒドロキシプロパン酸[R,(-)]-2-ヒドロキシプロパン酸D-MILK ACID(r)-lactateD-（& # 8722D-LaCLic Acid(R)-lacticaciD(-)LACTIC ACID

Lactic acid, D-D-2-Hydroxypropionic acid(R)-alpha-Hydroxypropionic acidDTXSID00470303Q6M5SET7WDTXCID8027030CHEBI:42111RefChem:584137

データベース識別子

CAS: 10326-41-7
PubChem CID: 61503
DTXSID: DTXSID0047030
ChEMBL: CHEMBL358850
ChEBI: CHEBI:42111
UNII: 3Q6M5SET7W
EC Number: 233-713-2
Nikkaji: J9.141C

物性

構造計算による物性

XLogP: -0.7
極性表面積: 57.5 Å²
水素結合供与体数: 2
水素結合受容体数: 3
回転可能結合数: 1
重原子数: 6
形式電荷: 0
複雑度: 59.1

実験および物理化学的性質

SpringerMaterials PropertiesCoriolis coupling

Melting Point52.8 °C

Physical DescriptionSolid

Dissociation Constants · 2 件

3.861

3.83

物理化学的性質

融点: 52.8 ° · 52.8°
比旋光度: 54621.5 · 54621.5 -2.6° (c = 8)
沸点: 227.6 · 227.6±0.0 °C(Predicted)
比重(密度): 1.276 · 1.276±0.06 g/cm3(Predicted)
蒸気圧: 3.8 Pa · 3.8Pa at 25℃
屈折率: 1.428 to · 1.4280 to 1.4320
FEMA: 2611 · 2611 | LACTIC ACID
貯蔵温度: -20 °C · -20°C
溶解性: 2 O: · H2O: 0.1 g/mL 無色透明
外見: 低融点固体
酸解離定数(Pka): 3.83 · pK = 3.83(at 25℃)
色: ホワイトからオフホワイト
臭い (Odor): 無臭の酸性
水溶解度: 水に可溶 (50mg/ml)
Merck: 14 · 14,5335
JECFA Number: 930 · 930
BRN: 1720252 · 1720252
安定性: 吸湿性
InChI: 1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/t2-/m1/s1
InChIKey: JVTAAEKCZFNVCJ-UWTATZPHSA-N
SMILES: C[C@@H](O)C(O)=O
LogP: -0.54 at · -0.54 at 20℃
CAS データベース: 10326 · 10326-41-7(CAS DataBase Reference)
EPAの化学物質情報: 2 · Propanoic acid, 2-hydroxy-, (2R)- (10326-41-7)

安全と法規制

GHS分類

GHS Classification · 6 件

Danger

H314 (10.4%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

P260, P264, P264+P265, P280, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P332+P317, P362+P364, P363, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 48 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Danger

H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

危険有害性情報

Regulatory Information · 4 件

Chemical: Propanoic acid, 2-hydroxy-, (2R)-

PMN - indicates a commenced PMN (Pre-Manufacture Notices) substance.

Status: Active Update: 22-09-2021 https://echa.europa.eu/registration-dossier/-/registered-dossier/12317

Propanoic acid, 2-hydroxy-, (2R)-: Does not have an individual approval but may be used under an appropriate group standard

Other Safety InformationEvaluation - Lactic acid isomers

Hazard Classes and Categories · 2 件

Skin Corr. 1C (10.4%)

Skin corrosion/irritation - Category 1

毒性情報

Carcinogen ClassificationNo indication of carcinogenicity to humans (not listed by IARC).

安全データ

F: 3-10
wgk: 3
tsca: TSCA listed
ridadr: UN 3265 8/PG III
hs_code: 2918110000
risk_code: 38-41
化審法: (2)-1369 届出不要化学物質
消防法: 危-4-3-III
hazard_code: Xi
safety_code: 26-39
hazard_class: 8
packing_group: III
Hazard Classifications: Eye Dam. 1Skin Corr. 1C
ストレージクラス: 8A - Combustible corrosive hazardous materials

化学と産業

薬理情報

Tissue LocationsBladder

Cellular LocationsExtracellular

Metabolite PathwaysLeigh Syndrome

用途と製造

UsesThis is an endogenously produced metabolite found in the human body. It is used in metabolic reactions, catabolic reactions or waste generation.

General Manufacturing InformationPropanoic acid, 2-hydroxy-, (2R)-: ACTIVE

応用分野 · 2 件

解説D-乳酸は厚い板状晶。融点は52.8℃で、比旋光度（－）2.6度である。DL-乳酸（ラセミ体で、D-乳酸とL-乳酸の混合物）は融点16.8℃で、旋光性は示さない。

使用D-(-)-Lactic acid is a useful biochemical for proteomics research. It is also used in the production of chiral drug and in the chemical synthesis. Lactic acid is used as a reagent in organic synthesis (in the manufacture of adhesives). It is used in the leather, textile, and tanning industries. It may be used as a plasticizer, a catalyst, or an acidifying agent. Lactic acid has even been used as a flavoring agent in the manufacture of tobacco products.