Acridine Orange Base (HCID 62344)

概要

Acridine orange free base is a member of the class of aminoacridines that is acridine carrying two dimethylamino substituents at positions 3 and 6. The hydrochloride salt is the fluorescent dye 'acridine orange', used for cell cycle determination. It has a role as a fluorochrome and a histological dye. It is an aromatic amine, a tertiary amino compound and a member of aminoacridines.

名称と識別子

優先名称: Acridine Orange Base
IUPAC: 3-N,3-N,6-N,6-N-tetramethylacridine-3,6-diamine
英語名: AcridineOrangeForMicroscopicalStaining
分子式: C17H20N3+
分子量: 266.3608

名称と別名

Acridine orange494-38-2Acridine Orange Base3,6-Bis(dimethylamino)acridineWaxoline Orange AOranz akridinova3,6-Di(dimethylamino)acridineRhoduline OrangeC.I. No. 46005:1Oranz rozpoustedlova 15Basic Orange 14Acridine Orange NO

名称をさらに表示

AcridineOrangeForMicroscopicalStaining3,6-Acridinediamine, N,N,N,N-tetramethyl-, conjugate monoacid

Rhoduline Orange NOF30N4O6XVVDTXSID60197783NSC-194350Acridine Orange NAcridine Orange RAcridine Orange NSSumitomo Acridine Orange NO

データベース識別子

CAS: 17251-70-6、494-38-2
PubChem CID: 62344
DTXSID: DTXSID60197783
ChEMBL: CHEMBL81880
ChEBI: CHEBI:87346
UNII: F30N4O6XVV
EC Number: 610-452-6
Nikkaji: J1.559H

物性

構造計算による物性

XLogP: 3.4
極性表面積: 19.4 Å²
水素結合供与体数: 0
水素結合受容体数: 3
回転可能結合数: 2
重原子数: 20
形式電荷: 0
複雑度: 298

実験および物理化学的性質

Chemical Classes · 2 件

Dyes -> Acridine Dyes

Physical DescriptionSolid; [Sigma-Aldrich MSDS]

安全と法規制

危険有害性情報

Regulatory Information · 3 件

Chemical: 3,6-Acridinediamine, N,N,N',N'-tetramethyl-

Acridine orange: Does not have an individual approval but may be used under an appropriate group standard

Acridine orange base: Does not have an individual approval but may be used under an appropriate group standard

Hazards Summary · 2 件

Has mutagenic potential that is enhanced by light; Acridine dyes are derived from 3,6-diaminoacridine, 9-(4'-aminophenyl)-3-aminoacridine, and 9-(4'-aminophenyl)-3,6-diaminoacridine. One of the oldest acridine dyes is chrysaniline. Acridine dyes have low light fastness. In the past they were used for printing on cotton. Currently, they are not commercially important. [Ullmann] See Acridine.

May cause irritation; Targets the blood; Mutagenic effects observed in laboratory experiments; [Sigma-Aldrich MSDS] See Acridine orange.

安全と保護具

Protective Action Criteria (PAC) · 3 件

0.090 [mg/m3]

0.98 [mg/m3]

5.9 [mg/m3]

毒性情報

Carcinogen Classification · 5 件

Acridine orange

Group 3: Not classifiable as to its carcinogenicity to humans

Volume 16: (1978) Some Aromatic Amines and Related Nitro Compounds – Hair Dyes, Colouring Agents and Miscellaneous Industrial Chemicals

1987

化学と産業

薬理情報

MeSH Pharmacological Classification · 2 件

Chemicals that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags.

Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes.

用途と製造

Uses · 2 件

N,N,N',N'-Tetramethyl-3,6-acridinediamine, monohydrochloride. Cationic cytochemical stain specific for cell nuclei, especially DNA. It is used as a supravital stain and in fluorescence cytochemistry. It may cause mutations in microorganisms. [ChemIDplus]

A coloring agent; [IARC]