Sodium saccharin

FCS -> FDA Inventory of Food Contact Substances Listed in 21 CFR

FCS -> FDA Inventory of Effective Food Contact Substance (FCS) Notifications

Saccharin, sodium salt appears as odorless white crystals or crystalline powder. Aqueous solution is neutral or alkaline to litmus, but not alkaline to phenolphthalein. Effloresces in dry air. Intensely sweet taste. (NTP, 1992)

Dry Powder; Liquid; Other Solid; Liquid

White odorless solid; Effloresces in dry air; [CAMEO] White odorless crystals; [Mallinckrodt Baker MSDS]

This chemical does not meet GHS hazard criteria for 95.6% (328 of 343) of all reports.

Not Classified

Aggregated GHS information provided per 343 reports by companies from 9 notifications to the ECHA C&L Inventory.

Chemical: 1,2-Benzisothiazol-3(2H)-one, 1,1-dioxide, sodium salt (1:1)

Regulation (EC) No 1831/2003 (amended)

1,2-Benzisothiazol-3(2H)-one, 1,1-dioxide, sodium salt (1:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1,2-Benzisothiazol-3(2H)-one, 1,1-dioxide, sodium salt (1:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

TP - indicates a substance that is the subject of a proposed TSCA section 4 test rule.

Status: Active Update: 29-03-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/14605

Sodium saccharin: Does not have an individual approval but may be used under an appropriate group standard

Causes changes in psychophysiological tests in acute oral studies of monkeys; Causes kidney and bladder changes in 36-week constant oral studies of rats; [RTECS] Usually contains about 5% water; [NTP] Acceptable daily intake (ADI) of 0-5 mg/kg; [JECFA] The dihydrate is CAS# 6155-57-3; Contains 5-6% water; May cause mechanical eye irritation; [Mallinckrodt Baker MSDS]

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter). (NTP, 1992)

Used as a non-nutritive sweetener, flavor, and in formulations for electroplating-bath brighteners; [Merck Index] Permitted for use as an inert ingredient in non-food pesticide products; [EPA] Used as an antimicrobial agent, flavor enhancer/agent/adjuvant, non-nutritive sweetener, and solvent or vehicle; [FDA] Used to stabilize drugs with a phenothiazine nucleus; [NTP]

Electroplating [Category: Plate]

Fragrance Ingredients

Food Additives -> SWEETENER -> JECFA Functional Classes

Food Additives -> SWEETENER -> JECFA Functional Classes

Cosmetics -> Oral care; Masking

Wholesale and Retail Trade

1,2-Benzisothiazol-3(2H)-one, 1,1-dioxide, sodium salt (1:1): ACTIVE