Sodium saccharin → N-[(4-Carbethoxybenzoyl)methyl]saccharin

HRID 864896

反応式

HRID 864896 の反応式
Br[CH2:2][C:3]([C:5]1[CH:15]=[CH:14][C:8]([C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:7][CH:6]=1)=[O:4].[CH:16]1[CH:21]=[C:20]2[C:22]([N-:24][S:25](=[O:27])(=[O:26])[C:19]2=[CH:18][CH:17]=1)=[O:23].[Na+]>CN(C)C=O>[C:9]([C:8]1[CH:14]=[CH:15][C:5]([C:3]([CH2:2][N:24]2[C:22](=[O:23])[C:20]3[C:19](=[CH:18][CH:17]=[CH:16][CH:21]=3)[S:25]2(=[O:27])=[O:26])=[O:4])=[CH:6][CH:7]=1)([O:11][CH2:12][CH3:13])=[O:10]

参加物

4

反応物 2

HCID 656582Sodium saccharinHCID 11966043Ethyl 4-(2-bromoacetyl)benzoate

生成物 1

HCID 19417371N-[(4-Carbethoxybenzoyl)methyl]saccharin

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

45 mmol of ethyl 4-bromoacetylbenzoate in 120 ml of dimethylformamide and 48 mmol of sodium saccharinate are maintained at 100° C. for 180 minutes. After evaporation of the solvent, taking up in 200 ml of water, extraction with dichloromethane, drying and evaporation, the residue is taken up in isopropyl ether, then filtered and taken to the expected product.

後処理

  1. customAfter evaporation of the solvent
  2. extractionextraction with dichloromethane
  3. customdrying
  4. customevaporation
  5. filtrationfiltered

出典と根拠

ORDレコード
ord-dcc26bda2edd4dff9ded4d69e88ab0cb
出典データセット
uspto-grants-1996_10
特許番号
US05565429

関連ノート

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