(Diethylamino)trimethylsilane (HCID 70454)

概要

N-(trimethylsilyl)diethylamine is an N-silyl compound that is diethylamine in which the amino hydrogen is replaced by a trimethylsilyl group. N-(trimethylsilyl)diethylamine is a derivatisation agent used in gas chromatography/mass spectrometry applications. It has a role as a chromatographic reagent. It is functionally related to a diethylamine.

名称と識別子

優先名称: (Diethylamino)trimethylsilane
IUPAC: N-ethyl-N-trimethylsilylethanamine
現地名: N-(トリメチルシリル)ジエチルアミン
英語名: N,N-Diethyl-1,1,1-trimethylsilylamine
分子式: C7H19NSi
分子量: 145.32

名称と別名

996-50-9N,N-Diethyl-1,1,1-trimethylsilylamineDiethylaminotrimethylsilane(Diethylamino)trimethylsilaneSilanamine, N,N-diethyl-1,1,1-trimethyl-(trimethylsilyl)diethylamineNSC 3776505LP9WK7P33TRIMETHYL(DIETHYLAMINO)SILANEEINECS 213-637-6NSC-377650Silylamine, N,N-diethyl-1,1,1-trimethyl-

名称をさらに表示

N-(トリメチルシリル)ジエチルアミンジエチルアミノトリメチルシラントリメチルシリルジエチルアミン(トリメチルシリル)ジエチルアミンジエチル(トリメチルシリル)アミン(N,N-ジエチルアミノ)トリメチルシラン(ジエチルアミノ)トリメチルシラントリメチル(ジエチルアミノ)シランN-エチル-N-(トリメチルシリル)エタンアミンN,N-ジエチルトリメチルシランアミンN,N-ジエチルトリメチルシリルアミンN,N-ジエチル-1,1,1-トリメチルシリルアミンN-トリメチルシリルジエチルアミンN,N‐ジエチル‐1,1,1‐トリメチルシリルアミンN,N-ジエチルアミノトリメチルシランTRIMETHYLSILYLDIETHYLAMINEN-(TRIMETHYLSILYL)DIETHYLAMINEDK436TMSDEACD4450(CH3)3SiN(C2H5)2Trimethylsilyl-diethylaminDiethyl(trimethylsilyl)amine

DTXSID5061370RefChem:406146N(Trimethylsilyl)diethylamineDTXCID2049133Silanamine, N,Ndiethyl1,1,1trimethyl213-637-6n,n-diethyl-1,1,1-trimethylsilanamineN,N-Diethyltrimethylsilylamine

データベース識別子

CAS: 996-50-9
PubChem CID: 70454
DTXSID: DTXSID5061370
ChEBI: CHEBI:85070
UNII: 5LP9WK7P33
EC Number: 213-637-6
Nikkaji: J150.863F

物性

構造計算による物性

極性表面積: 3.2 Å²
水素結合供与体数: 0
水素結合受容体数: 1
回転可能結合数: 3
重原子数: 9
形式電荷: 0
複雑度: 71.5

実験および物理化学的性質

Chemical ClassesMetals -> Metalloid Compounds (Silicon)

SpringerMaterials Properties15N nuclear magnetic resonance spectrum

Physical DescriptionColorless liquid; [Alfa Aesar MSDS]

物理化学的性質

融点: -10 °C · -10°C
沸点: 125 · 125-126 °C(lit.)
比重(密度): 0.767 g/mL · 0.767 g/mL at 25 °C(lit.)
蒸気密度: 1 · >1 (vs air)
屈折率: 20 · n20/D 1.411(lit.)
闪点: 50 °F · 50 °F
貯蔵温度: 2 · Keep in dark place,Inert atmosphere,2-8°C
溶解性: Chloroform (Sparingly), DMSO (Slightly), Ethyl Acetate (Slightly)
酸解離定数(Pka): 11.27 · 11.27±0.70(Predicted)
外見: clear liquid
比重: 0.763 · 0.763
色: Colorless to Light yellow
水溶解度: 分解する
BRN: 635718 · 635718
InChI: 1S/C7H19NSi/c1-6-8(7-2)9(3,4)5/h6-7H2,1-5H3
InChIKey: JOOMLFKONHCLCJ-UHFFFAOYSA-N
SMILES: CCN(CC)[Si](C)(C)C
CAS データベース: 996 · 996-50-9(CAS DataBase Reference)
NISTの化学物質情報: -1 · N,N-Diethyl-1,1,1-trimethylsilylamine(996-50-9)
EPAの化学物質情報: -1 · Silanamine, N,N-diethyl-1,1,1-trimethyl- (996-50-9)

化学的性質

化学的特性Colorless liquid

安全と法規制

GHS分類

GHS Classification · 4 件

Danger

H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]

P210, P233, P240, P241, P242, P243, P260, P264, P280, P301+P330+P331, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P321, P363, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 71 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

危険有害性情報

Regulatory Information · 3 件

Chemical: Silanamine, N,N-diethyl-1,1,1-trimethyl-

Status: Active Update: 06-12-2021 https://echa.europa.eu/registration-dossier/-/registered-dossier/33669

Diethylaminotrimethylsilane: Does not have an individual approval but may be used under an appropriate group standard

Hazards SummaryCauses burns; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; [Alfa Aesar MSDS] See Hexamethyldisilazane.

Hazard Classes and CategoriesFlam. Liq. 2 (100%)

毒性情報

Adverse EffectsDermatotoxin - Skin burns.

安全データ

F: 10-21
wgk: 3
tsca: TSCA listed
ridadr: UN 2733 3/PG 2
hs_code: 29310095
risk_code: 11-34
消防法: 危-4-1-II
hazard_code: F,C
safety_code: 26-36/37/39-45-24/25-16
hazard_class: 3
packing_group: II
Hazard Classifications: Flam. Liq. 2Skin Corr. 1B
ストレージクラス: 3 - Flammable liquids

化学と産業

用途と製造

General Manufacturing InformationSilanamine, N,N-diethyl-1,1,1-trimethyl-: ACTIVE

応用分野 · 3 件

用途GC分析における前処理剤、シリル化剤。

使用Trimethylsilyldiethylamine is a reagent used as an electrophilic trimethylsilyl source for cleavage of cyclic ethers, esters, oxazolidines, and cyclic acetals; also as a nucleophilic source of the diethylamino group, participating in the following synthesis reactions: Trimethylsilyl Group Transfer, Diethylamino Group Transfer, Trimethylsilyldiethylamine as Halosilane Equivalent, Silylation of Alcohols, Mild Generation of Phosphonochloridates, Silylation of Amines, Diethylamino Group Transfer, Conjugate Addition, Aminoalkylation of Aldehydes, Enamine and Silyl Enol Ether Preparation, Mediation of 1,4-Conjugate Additions, etc.

一般的な説明N,N-Diethyltrimethylsilylamine is a silylating agent used to derivatize polar organic compounds.

調製方法 · 1 件

純化方法Fractionate it through a 2ft vacuum-jacketed column containing Helipak packing with a reflux ratio of 10:1. [Sauer & Hasek J Am Chem Soc 68 241 1946, Langer et al. J Org Chem 23 50 1958, Rühlmann J Prakt Chem 9 315 1959, Beilstein 4 IV 4010.]

上流・下流製品情報

下流製品

(ジエチルアミノ)サルファートリフルオリド [(4-メトキシフェニル)エチニル]トリメチルシラン N,N,N',N'-テトラエチルメタンジアミン 2-(トリメチルシリルオキシ)フラン 2-ピロリドンヘキサメチルジシロキサン N,N-ビス(トリメチルシリル)-1,4-ブタンジアミン

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補足説明

定義ChEBI: An N-silyl compound that is diethylamine in which the amino hydrogen is replaced by a trimethylsilyl group. N-(trimethylsilyl)diethylamine is a derivatisation agent used in gas chromatography/mass spectrometry applicat ons.