(Diethylamino)trimethylsilane → (S)-trimethyl{[methyl(oxo)phenyl-lambda6-sulfanylidene]amino}silane

HRID 391566

反応式

HRID 391566 の反応式
[CH3:1][S@:2]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)(=[NH:4])=[O:3].[CH3:11][Si:12](N(CC)CC)([CH3:14])[CH3:13]>C(#N)C>[CH3:11][Si:12]([CH3:14])([CH3:13])[N:4]=[S@@:2]([CH3:1])(=[O:3])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

参加物

4

反応物 2

HCID 70454(Diethylamino)trimethylsilane2 回HCID 25036288(S)-(+)-S-Methyl-S-phenylsulfoximine

生成物 1

HCID 25041124(S)-trimethyl{[methyl(oxo)phenyl-lambda6-sulfanylidene]amino}silane

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

反応条件

温度
65 °C

実験手順

To a stirred pre-warmed solution of (S)-(+)-S-methyl-S-phenylsulphoximine (3 g, 18.7 mmol) in acetonitrile (2 mL) at 65° C. was added (trimethylsilyl)diethylamine (4.12 g, 21.1 mmol) dropwise via a syringe. The reaction was maintained at 65° C. and stirred for 3 hours. Additional amount of (trimethylsilyl)diethylamine (2 mL, 10.2 mmol) was added and the reaction mixture was stirred at 65° C. overnight. The reaction was then concentrated under reduced pressure and dried under vacuum to give the title compound. This material was used directly in next step of the synthesis without further purification.

後処理

  1. stirringthe reaction mixture was stirred at 65° C. overnight
  2. concentrationThe reaction was then concentrated under reduced pressure
  3. customdried under vacuum

出典と根拠

ORDレコード
ord-8440d5b05f374f379ffa4ec1ef4a9cee
出典データセット
uspto-grants-2013_02
特許番号
US08383825B2

関連ノート

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