Phenidone (HCID 7090)

概要

photographic developer; RN given refers to parent cpd; structure

名称と識別子

優先名称: Phenidone
IUPAC: 1-phenylpyrazolidin-3-one
現地名: フェニドン
英語名: Phenidone
分子式: C9H10N2O
分子量: 162.19

名称と別名

Phenidone92-43-31-PHENYL-3-PYRAZOLIDINONE1-Phenyl-3-pyrazolidone3-Pyrazolidinone, 1-phenyl-DTXSID1049433H0U5612P6KNSC-30306DTXCID0029393RefChem:172692202-155-11-phenylpyrazolidin-3-one

名称をさらに表示

1-フェニル-3-ピラゾリドン1-フェニルピラゾリジン-3-オン1-フェニル-3-ピラゾリジノンフェニルピラゾリドン1-フェニル-3-オキソピラゾリジン1‐フェニル‐3‐ピラゾリジノンフェニドンPHENIDONE AOprea1phenitone4072-30-4STK084358graphidone

FenidonPyrazolidinone, 1-phenyl-1-Phenyl-3-oxopyrazolidine2-Pyrazolin-3-ol, 1-phenyl-MFCD000030941-P-3-P1-Phenyl-pyrazolidin-3-one1-Phenylpyrazolid-3-one

データベース識別子

CAS: 92-43-3
PubChem CID: 7090
DTXSID: DTXSID1049433
ChEMBL: CHEMBL7660
UNII: H0U5612P6K
EC Number: 202-155-1
Nikkaji: J38.160H

物性

構造計算による物性

XLogP: 0.9
極性表面積: 32.3 Å²
水素結合供与体数: 1
水素結合受容体数: 2
回転可能結合数: 1
重原子数: 12
形式電荷: 0
複雑度: 175

実験および物理化学的性質

Chemical ClassesNitrogen Compounds -> Pyrazoles

SpringerMaterials PropertiesBoiling point

Vapor Pressure0.0000163 [mmHg]

Physical DescriptionSolid; [Merck Index] White powder; [Alfa Aesar MSDS]

物理化学的性質

融点: 119 · 119-121 °C(lit.)
沸点: 288.88 °C · 288.88°C (rough estimate)
比重(密度): 1.1436 · 1.1436 (rough estimate)
蒸気圧: 0.002 Pa · 0.002Pa at 25℃
屈折率: 1.56 · 1.5600 (estimate)
貯蔵温度: Sealed in dry,Room Temperature
溶解性: 0.1 g/mL、透明 · メタノール: 0.1 g/mL、透明
外見: 白からオフホワイトの固体。
酸解離定数(Pka): 9.5 · 9.50±0.30(Predicted)
色: White to Light yellow to Light orange
水溶解度: 熱湯に溶ける
Merck: 14 · 14,7309
BRN: 131856 · 131856
安定性: 安定していますが、光に敏感です。強酸、強酸化剤、強塩基とは相容れない。
InChI: 1S/C9H10N2O/c12-9-6-7-11(10-9)8-4-2-1-3-5-8/h1-5H,6-7H2,(H,10,12)
InChIKey: CMCWWLVWPDLCRM-UHFFFAOYSA-N
SMILES: O=C1CCN(N1)c2ccccc2
LogP: 0.119 at · 0.119 at 25℃
CAS データベース: 92 · 92-43-3(CAS DataBase Reference)
NISTの化学物質情報: 1 · 1-Phenyl-3-pyrazolidinone(92-43-3)
EPAの化学物質情報: 3 · 3-Pyrazolidinone, 1-phenyl- (92-43-3)

化学的性質

化学的特性light beige powder or crystals

安全と法規制

GHS分類

GHS Classification · 6 件

Warning

H302: Harmful if swallowed [Warning Acute toxicity, oral]

P264, P270, P273, P301+P317, P330, P391, and P501 (click each P-code to see the statement)

Warning

H302 (98.4%): Harmful if swallowed [Warning Acute toxicity, oral]

P264, P270, P273, P301+P317, P330, P391, and P501 (click each P-code to see the statement)

危険有害性情報

Regulatory Information · 3 件

Chemical: 3-Pyrazolidinone, 1-phenyl-

Status: Active Update: 12-05-2020 https://echa.europa.eu/registration-dossier/-/registered-dossier/17573

3-Pyrazolidinone, 1-phenyl-: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

Hazards SummaryPhenidone is one of the photographic chemicals in the supplemental patch testing tray sold by Chemotechnique. [Marks, Appendix] An irritant; Harmful by ingestion; [Alfa Aesar MSDS] See 4-Hydroxymethyl-4-methyl-1-phenyl-3-pyrazolidinone.

Hazard Classes and Categories · 3 件

Acute Tox. 4 (98.4%)

Acute toxicity - category 4

Acute Tox. 4 *

毒性情報

Adverse EffectsSkin Sensitizer - An agent that can induce an allergic reaction in the skin.

安全データ

wgk: 2
tsca: TSCA listed
rtecs: UQ8750000
ridadr: UN 2811 6.1/PG 3
毒性: LD50 orl-rat: 200 mg/kg KODAK* -,-,71
hs_code: 29331990
risk_code: 22-51/53
化審法: (9)-1855
hazard_code: Xn,N
safety_code: 61
hazard_class: 6.1
packing_group: III
Hazard Classifications: Acute Tox. 4 OralAquatic Chronic 2
ストレージクラス: 11 - Combustible Solids

毒性と防護

毒性LD50 200 mg/kg(ラット，経口)．

化学と産業

薬理情報

MeSH Pharmacological Classification · 3 件

Naturally occurring or synthetic substances that inhibit or retard oxidation reactions. They counteract the damaging effects of oxidation in animal tissues.

Compounds that bind to and inhibit that enzymatic activity of LIPOXYGENASES. Included under this category are inhibitors that are specific for lipoxygenase subtypes and act to reduce the production of LEUKOTRIENES.

Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes.

用途と製造

Uses · 2 件

Used as a non-staining, high-contrast photographic developer; [Merck Index] Used in photography (developer); [www.ci.tucson.az.us/arthazards/medium.html]

Photographic Processing [Category: Other]

General Manufacturing Information3-Pyrazolidinone, 1-phenyl-: ACTIVE

応用分野 · 4 件

解説フェニドン，結晶．融点121 ℃．熱水，メタノールに可溶．ヒドロキノンと組み合わせて高感度ネガフィルムの現像に用いられ，これをPQ現像液をよぶ．森北出版「化学辞典（第2版）

用途抗炎症剤で，アラキドン酸カスケードの抑制作用も示す．

説明Phenidone is a moderately active developing agent that exhibits a synergistic effect when combined with other developing agents. The developing behavior of phenidone indicates that, in most cases, it has no induction period and produces a rapid development curve. A developer containing phenidone and hydroquinone (PQ-type developer) is now the predominant type of developer used for X-ray films and provides excellent development performance.

使用Phenidone is used as black and white photographic developer.

上流・下流製品情報

上流原料

ナトリウムメトキシドフェニルヒドラジン 1-フェニル-2-(β-シアノエチル)ヒドラジン Acetamide, N-(4,5-dihydro-1-phenyl-1H-pyrazol-3-yl)-1-フェニル-2-ピラゾリン-3-アミン N-エチルアクリルアミドアニリン塩化フェニルヒドラジニウムアクリル酸エチルアクリルアミド acrylic acid methyl ester

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フェニドン

基本情報

概要